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{"sheet":"Hoja1","index":0,"n_rows":127,"n_cols":11,"rows_kept":127,"cut":false,"hidden":false,"merged":[]}
[null,null,null,"DISTRIBUCIÓN"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,"ACCP","Caso base","Probabilístico","Min","Max","Distribución"]
[null,"ACCP_V_a_V",0.97899999999999998,{"$f":"+RANDBETWEEN(E12*10000,F12*10000)/10000","v":0.79630000000000001},{"$f":"ACCP_V_a_V*0.75","v":0.73424999999999996},{"$f":"IF(ACCP_V_a_V*1.25>1,1,ACCP_V_a_V*1.25)","v":1},"Uniforme",null,0.97899999999999998]
[null,"ACCP-V_a_SA",1.6E-2,1.8599999999999998E-2,{"$f":"ACCP_V_a_SA*0.75","v":1.2E-2},{"$f":"ACCP_V_a_SA*1.25","v":0.02},"Uniforme",null,1.6E-2]
[null,"ACCP_V_a_M",5.0000000000000001E-3,3.8E-3,{"$f":"ACCP_V_a_M*0.75","v":3.7499999999999999E-3},{"$f":"ACCP_V_a_M*1.25","v":6.2500000000000003E-3},"Uniforme",null,5.0000000000000001E-3]
[null,"ACCP_SA_a_V",0.71,0.62270000000000003,{"$f":"ACCP_SA_a_V*0.75","v":0.53249999999999997},{"$f":"ACCP_SA_a_V*1.25","v":0.88749999999999996},"Uniforme",null,0.71]
[null,"ACCP_SA_a_SA",0.28499999999999998,0.29980000000000001,{"$f":"ACCP_SA_a_SA*0.75","v":0.21375},{"$f":"ACCP_SA_a_SA*1.25","v":0.35624999999999996},"Uniforme",null,0.28499999999999998]
[null,"ACCP_SA_a_M",5.0000000000000001E-3,4.3E-3,{"$f":"ACCP_SA_a_M*0.75","v":3.7499999999999999E-3},{"$f":"ACCP_SA_a_M*1.25","v":6.2500000000000003E-3},"Uniforme",null,5.0000000000000001E-3]
[null,"ACCP_M_a_M",1,0.80779999999999996,{"$f":"ACCP_M_a_M*0.75","v":0.75},{"$f":"IF(ACCP_M_a_M*1.25>1,1,ACCP_M_a_M*1.25)","v":1},"Uniforme"]
[null,"EMZ_V_a_V",0.99483999999999995,0.93789999999999996,{"$f":"C19*0.75","v":0.74612999999999996},{"$f":"IF(C19*1.25>1,1,C19*1.25)","v":1},"Uniforme"]
[null,"EMZ_V_a_SA",1.6000000000000001E-4,2.0000000000000001E-4,1.2000000000000002E-4,2.0000000000000001E-4,"Uniforme"]
[null,"EMZ_V_a_M",5.0000000000000001E-3,5.1000000000000004E-3,3.7499999999999999E-3,6.2500000000000003E-3,"Uniforme"]
[null,"EMZ_SA_a_V",0.71,0.85029999999999994,0.53249999999999997,0.88749999999999996,"Uniforme"]
[null,"EMZ_SA_a_SA",0.28500000000000003,0.23350000000000001,0.21375000000000002,0.35625000000000007,"Uniforme"]
[null,"EMZ_SA_a_M",5.0000000000000001E-3,{"$f":"+RANDBETWEEN(E24*10000,F24*10000)/10000","v":5.4999999999999997E-3},3.7499999999999999E-3,6.2500000000000003E-3,"Uniforme"]
[null,"EMZ_M_a_M",1,0.8256,0.75,1,"Uniforme"]
[null,null,null,null,null,"buscar en estudios originales a vere si hay error estandar o intervalo de confianza"]
[]
[]
[null,"Tratamiento 3TC ZDV","Caso base","Probabilístico","Min","Max","Distribución",null,"Caso base"]
[null,"RR",0.01,{"$f":"+RANDBETWEEN(E30*10000,F30*10000)/10000","v":3.1399999999999997E-2},4.0000000000000001E-3,4.3999999999999997E-2,"Uniforme",null,0.01]
[]
[null,"Costos"]
[]
[null,"Estados","Caso base","Probabilístico","Inferior","Superior","Distribución",null,"Caso base",null,"ecnología (medicamentos)Costo promedio año caso tipoEmicizumab 30 mg (Dosis 1,5mg/kg > Calcular peso promedio)$             300.495.922Feiba Profilaxis 1000 U ( 70 a 100 U/kg en dias alternos)$             429.156.000Factor VIII (Sangrado leve, Moderado y severo)$                   123.254Feiba Tratamiento 1000 U ( 50 a 100 U/kg por 3 a 7 dias dependiendo de sangrado leve, moderado o severo)$                1.965.000"]
[null,"c_EMZ_A",300495922,{"$f":"RANDBETWEEN(E35,F35)","v":368257322},{"$f":"+C35*(1-25%)","v":225371941.5},{"$f":"+C35*(1+25%)","v":375619902.5},"Uniforme"]
[null,"c_EMZ_B",300619176,{"$f":"RANDBETWEEN(E36,F36)","v":370975070},{"$f":"+C36*(1-25%)","v":225464382},{"$f":"+C36*(1+25%)","v":375773970},"Uniforme"]
[null,"c_ACCP_A",429156000,440878043,321867000,536445000,"Uniforme"]
[null,"c_ACCP_B",431121000,507535286,323340750,538901250,"Uniforme"]
[]
[null,"Tratamiento ZDV","Caso base","Probabilístico","Inferior","Superior","Distribución",null,"Caso base"]
[null,"ACCP",243745674,{"$f":"RANDBETWEEN(E41,F41)","v":190200519},142251039,242266992,"Uniforme",null,243745674]
[]
[null,"Tratamiento 3TC ZDV","Caso base","Probabilístico","Inferior","Superior","Distribución",null,"Caso base"]
[null,"EMZ",243745674,{"$f":"RANDBETWEEN(E44,F44)","v":72318024},47664504,84622767,"Uniforme",null,243745674]
[]
[null,null,"Caso base","Probabilístico","Inferior","Superior","Distribución",null,"Caso base"]
[null,"TasaDescuento",0.05,{"$f":"+RANDBETWEEN(E47*10000,F47*10000)/10000","v":5.1900000000000002E-2},0,0.12,"Uniforme",null,0.06]
[null,"Year_effect",0,null,null,null,null,null,2]
[null,null,null,null,null,"supuestos del modelo"]
[null,"Beneficios en Salud","Caso base","EMZ","ACCP","probabilidades a expertos",null,null,"Caso base"]
[null,"Vivo",1,0.76829999999999998,0.56969999999999998,"qalys se puede manejar para ambos",null,null,1]
[null,"Muerto",0,null,null,"Recomendaciones en cac: capturen calidad de vida cuando estan vivos y tienen sangrado y los que siguen vivos y no siguieron sangrado",null,null,0]
[]
[]
[null,null,"Caso base","Probabilístico","Inferior","Superior","Distribución"]
[null,"c_EMZ_A_02",190814910.64269999,{"$f":"RANDBETWEEN(E56,F56)","v":211815912},147468821.48543999,234160999.79999998,"UNIFORME"]
[null,"c_EMZ_A_03",222967974.3258,204171151,172317898.49164799,273618050.15999997,"UNIFORME"]
[null,"c_EMZ_A_04",253919054.31979999,269462973,196238038.03967997,311600070.59999996,"UNIFORME"]
[null,"c_EMZ_A_05",286372613.92519999,316367324,221319349.41043195,351425878.43999994,"UNIFORME"]
[null,"c_EMZ_A_06",321530636.83099997,384824149,248490770.06207997,394570503.59999996,"UNIFORME"]
[null,"c_EMZ_A_07",349476757.60229999,281704287,270088565.96467197,428864949.24000001,"UNIFORME"]
[null,"c_EMZ_A_08",385235772.3527,394354022,297724455.34540796,472747089.36000001,"UNIFORME"]
[null,"c_EMZ_A_09",429709168.84899998,525512386,332095141.29791999,527323196.40000004,"UNIFORME"]
[null,"c_EMZ_A_10",484098930.7802,566015203,374129561.28038394,594068300.27999997,"UNIFORME"]
[null,"c_EMZ_A_11",484098930.7802,543898931,374129561.28038394,594068300.27999997,"UNIFORME"]
[null,"c_EMZ_A_12",621726063.18079996,742139458,480492900.24153602,762959226.12000012,"UNIFORME"]
[null,"c_EMZ_A_13",701357482.58280003,605481664,542035006.84569597,860679958.31999993,"UNIFORME"]
[null,"c_EMZ_A_14",783543117.32420003,952046709,605551105.54847991,961535129.0999999,"UNIFORME"]
[null,"c_EMZ_A_15",818701140.23010004,661073695,632722526.20012796,1004679754.2600001,"UNIFORME"]
[null,"c_EMZ_A_16",935594053.99389994,1122223016,723061694.00774395,1148126413.98,"UNIFORME"]
[null,"c_EMZ_A_17",992087287.38100004,841801565,766721754.54201603,1217452820.22,"UNIFORME"]
[null,"c_EMZ_A_18",1024540846.9864,878577205,791803065.91276789,1257278628.0599999,"UNIFORME"]
[null,"c_EMZ_A_>19",1051735727.952,1099714597,812820275.90399992,1290651180,"UNIFORME"]
[null,"c_EMZ_B_02",190877523.54260001,{"$f":"RANDBETWEEN(E74,F74)","v":196204900},147489702.81527999,234265344.26999998,"UNIFORME"]
[null,"c_EMZ_B_03",223041137.74590001,233278644,172342298.407776,273739977.08399999,"UNIFORME"]
[null,"c_EMZ_B_04",254002373.84810001,229702631,196265825.00615996,311738922.68999994,"UNIFORME"]
[null,"c_EMZ_B_05",286466582.57660002,235121092,221350687.84718394,351582477.30599993,"UNIFORME"]
[null,"c_EMZ_B_06",321636142.03250003,304184196,248525955.92495996,394746328.13999999,"UNIFORME"]
[null,"c_EMZ_B_07",349591432.88200003,391889730,270126810.03806394,429056055.72600001,"UNIFORME"]
[null,"c_EMZ_B_08",385362181.38840002,356907536,297766612.61289597,472957750.16400003,"UNIFORME"]
[null,"c_EMZ_B_09",429850171.1275,527502522,332142165.39503998,527558176.86000001,"UNIFORME"]
[null,"c_EMZ_B_10",484257780.20029998,405965058,374182537.37860793,594333023.02199996,"UNIFORME"]
[null,"c_EMZ_B_11",484257780.20029998,586992544,374182537.37860793,594333023.02199996,"UNIFORME"]
[null,"c_EMZ_B_12",621930072.77119994,593909630,480560937.20443201,763299208.33800018,"UNIFORME"]
[null,"c_EMZ_B_13",701587621.96619999,850410288,542111758.06435192,861063485.86799991,"UNIFORME"]
[null,"c_EMZ_B_14",783800224.62590003,772249451,605636850.53675997,961963598.71499991,"UNIFORME"]
[null,"c_EMZ_B_15",818969784.08179998,726570481,632812118.61453593,1005127449.5490001,"UNIFORME"]
[null,"c_EMZ_B_16",935901054.4095,1126356404,723164078.29192793,1148638030.527,"UNIFORME"]
[null,"c_EMZ_B_17",992412825.15910006,1087499228,766830321.01519203,1217995329.303,"UNIFORME"]
[null,"c_EMZ_B_18",1024877033.8875999,944346958,791915183.85621583,1257838883.9189999,"UNIFORME"]
[null,"c_EMZ_B_>19",1052080838.424,1270898565,812935369.84799993,1291226307,"UNIFORME"]
[null,"c_ACCP_A_02",455033790.05760002,385977145,380611692.11519998,529455888,"UNIFORME"]
[null,"c_ACCP_A_03",531708775.15390003,545780174,444746260.70784009,618671289.60000002,"UNIFORME"]
[null,"c_ACCP_A_04",605517405.66719997,636694581,506483275.33439988,704551535.99999976,"UNIFORME"]
[null,"c_ACCP_A_05",682908979.40929997,717690718,571217232.41855991,794600726.39999998,"UNIFORME"]
[null,"c_ACCP_A_06",766749850.96319997,758287094,641345685.92639983,892154015.99999976,"UNIFORME"]
[null,"c_ACCP_A_07",833392595.01890004,701790105,697088815.63776004,969696374.4000001,"UNIFORME"]
[null,"c_ACCP_A_08",918666643.86430001,889126475,768416046.12864006,1068917241.6,"UNIFORME"]
[null,"c_ACCP_A_09",1024721763.4368,1125463536,857125542.87360001,1192317984,"UNIFORME"]
[null,"c_ACCP_A_10",1154424308.3194001,986180638,965614859.83871984,1343233756.8,"UNIFORME"]
[null,"c_ACCP_A_11",1154424308.3194001,1064758509,965614859.83871984,1343233756.8,"UNIFORME"]
[null,"c_ACCP_A_12",1482621908.0774,1279797003,1240134788.95488,1725109027.2,"UNIFORME"]
[null,"c_ACCP_A_13",1672517899.2038,1586963813,1398972739.2076802,1946063059.2,"UNIFORME"]
[null,"c_ACCP_A_14",1868504893.8192,1809439504,1562905491.6384001,2174104296,"UNIFORME"]
[null,"c_ACCP_A_15",1952345765.3731,1863330149,1633033945.14624,2271657585.5999999,"UNIFORME"]
[null,"c_ACCP_A_16",2231098748.5738001,2201680114,1866196068.3475199,2596001428.7999997,"UNIFORME"]
[null,"c_ACCP_A_17",2365817413.9766002,2677152709,1978881104.7532802,2752753723.2000003,"UNIFORME"]
[null,"c_ACCP_A_18",2443208987.7186999,2693754760,2043615061.8374398,2842802913.5999999,"UNIFORME"]
[null,"c_ACCP_A_>19",2508060260.1599998,2105843769,2097859720.3199999,2918260800,"UNIFORME"]
[null,"c_ACCP_B_02",456032010.05760002,512868076,381010980.11519998,531053040,"UNIFORME"]
[null,"c_ACCP_B_03",532875199.15390003,582185209,445212830.30784011,620537568,"UNIFORME"]
[null,"c_ACCP_B_04",606845745.66719997,583311074,507014611.33439988,706676879.99999976,"UNIFORME"]
[null,"c_ACCP_B_05",684407095.40929997,719423479,571816478.81855989,796997712,"UNIFORME"]
[null,"c_ACCP_B_06",768431890.96319997,891538067,642018501.92639983,894845279.99999976,"UNIFORME"]
[null,"c_ACCP_B_07",835220831.01890004,886334344,697820110.03776002,972621552.00000012,"UNIFORME"]
[null,"c_ACCP_B_08",920681947.86430001,815689045,769222167.72864008,1072141728,"UNIFORME"]
[null,"c_ACCP_B_09",1026969723.4368,967346462,858024726.87360001,1195914720,"UNIFORME"]
[null,"c_ACCP_B_10",1156956800.3194001,1159071737,966627856.6387198,1347285744,"UNIFORME"]
[null,"c_ACCP_B_11",1156956800.3194001,1220823325,966627856.6387198,1347285744,"UNIFORME"]
[null,"c_ACCP_B_12",1485874376.0774,1282862263,1241435776.15488,1730312976,"UNIFORME"]
[null,"c_ACCP_B_13",1676186947.2038,1946690767,1400440358.4076803,1951933536,"UNIFORME"]
[null,"c_ACCP_B_14",1872603883.8192,1769177357,1564545087.6384001,2180662680,"UNIFORME"]
[null,"c_ACCP_B_15",1956628679.3731,1749367094,1634747110.7462399,2278510248,"UNIFORME"]
[null,"c_ACCP_B_16",2235993170.5738001,2312679453,1868153837.1475198,2603832503.9999995,"UNIFORME"]
[null,"c_ACCP_B_17",2371007371.9766002,2308373989,1980957087.9532802,2761057656.0000005,"UNIFORME"]
[null,"c_ACCP_B_18",2448568721.7186999,2449549999,2045758955.4374397,2851378488,"UNIFORME"]
[null,"c_ACCP_B_>19",2513562260.1599998,2229387844,2100060520.3199999,2927064000,"UNIFORME"]

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[null,"DETERMINISTICO"]
["PROFILAXIS ACCP"]
[null,"tablas de vida del dane para tomar la probabilidd de muerte de la poblacion general",null,null,null,null,null,null,"Número de pacientes",null,null,"Expectativa de vida",null,null,null,"Costos acumulados"]
[null,"Vivo","Sangrado Articular","Muera",null,"Costo ACCP - V","Costo ACCP SA",null,"Vivo","Sangrado Articular","Muera","Vivo","Sangrado Articular","Muera","AVAC","Vivo","Sangrado Articular","Muera"]
["Vivo",{"$f":"+ACCP_V_a_V","v":0.97899999999999998},{"$f":"+ACCP_V_a_SA","v":1.6E-2},{"$f":"+ACCP_V_a_M","v":5.0000000000000001E-3},"c_ACCP_02",{"$f":"+Hoja1!$C$92","v":455033790.05760002},{"$f":"+Hoja1!$C$110","v":456032010.05760002},0,1000,0,0,{"$f":"+I5*1","v":1000},{"$f":"+J5*1","v":0},{"$f":"+K5*0","v":0},{"$f":"+I5*Hoja1!$E$51","v":569.69999999999993},{"$f":"+I5*($B$24+F5)/(1)^H5","v":698779464057.59998},{"$f":"+J5*($B$24+G5)/(1)^H5","v":0},0,null,null,null,null,null,null,null,null,null,"m1",{"$f":"+MMULT(B5:D7,B5:D7)","v":0.96980100000000002},2.0223999999999999E-2,9.9750000000000012E-3,"m5",{"$f":"+AC5+B5+AC9+AC13+AC17","v":4.8250457344620585},0.100452394284816,7.4501871253125004E-2]
["Sangrado Articular",{"$f":"+ACCP_SA_a_V","v":0.71},{"$f":"+ACCP_SA_a_SA","v":0.28499999999999998},{"$f":"+ACCP_SA_a_M","v":5.0000000000000001E-3},"c_ACCP_02",{"$f":"+Hoja1!$C$92","v":455033790.05760002},{"$f":"+Hoja1!$C$110","v":456032010.05760002},1,{"$f":"+I5*$B$5+J5*$B$6+K5*$B$7","v":979},{"$f":"+I5*$C$5+J5*$C$6+K5*$C$7","v":16},{"$f":"+I5*$D$5+J5*$D$6+K5*$D$7","v":5},{"$f":"+I6*1","v":979},{"$f":"+J6*1","v":16},{"$f":"+K6*0","v":0},{"$f":"+(I6*Hoja1!$E$51)+(J6*Hoja1!$E$51)","v":566.85149999999999},{"$f":"+I6*($B$24+F6)/(1+TasaDescuento)^H6","v":651528662202.27649},{"$f":"+J6*($B$24+G6)/(1+TasaDescuento)^H6","v":10663278995.163429},0,null,null,null,null,null,null,null,null,null,null,0.89744000000000002,9.2584999999999987E-2,9.9749999999999995E-3,null,4.4575749963887095,0.46792313235816496,7.450187125312499E-2]
["Muera",0,0,{"$f":"+ACCP_M_a_M","v":1},"c_ACCP_02",{"$f":"+Hoja1!$C$92","v":455033790.05760002},{"$f":"+Hoja1!$C110","v":456032010.05760002},2,{"$f":"+I6*$B$5+J6*$B$6+K6*$B$7","v":969.80100000000004},{"$f":"+I6*$C$5+J6*$C$6+K6*$C$7","v":20.224},{"$f":"+I6*$D$5+J6*$D$6+K6*$D$7","v":9.9750000000000014},{"$f":"+I7*1","v":969.80100000000004},{"$f":"+J7*1","v":20.224},{"$f":"+K7*0","v":0},{"$f":"+(I7*Hoja1!$E$51)+(J7*Hoja1!$E$51)","v":564.01724249999995},614673036755.12427,12836556809.415785,0,null,null,null,null,null,null,null,null,null,null,0,0,1,null,0,0,5]
[null,null,null,null,"c_ACCP_03",{"$f":"+Hoja1!$C93","v":531708775.15390003},{"$f":"+Hoja1!$C111","v":532875199.15390003},3,{"$f":"+I7*$B$5+J7*$B$6+K7*$B$7","v":963.79421900000011},{"$f":"+I7*$C$5+J7*$C$6+K7*$C$7","v":21.280656},{"$f":"+I7*$D$5+J7*$D$6+K7*$D$7","v":14.925125000000001},963.79421900000011,21.280656,0,{"$f":"+(I8*Hoja1!$E$51)+(J8*Hoja1!$E$51)","v":561.19715628749998},645613661757.78711,14276645411.085438,0]
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["Matriz Fundamental",{"$f":"+MINVERSE(B13:C14)","v":195.62243502051899},4.3775649794801437,null,"c_ACCP_11",{"$f":"+Hoja1!$C101","v":1154424308.3194001},{"$f":"+Hoja1!$C119","v":1156956800.3194001},11,925.49829229519219,20.85628751825077,{"$f":"+I15*$D$5+J15*$D$6+K15*$D$7","v":53.645420186556962},925.49829229519219,20.85628751825077,0,{"$f":"+(I16*Hoja1!$E$51)+(J16*Hoja1!$E$51)","v":539.13820411971847},756577298437.52075,17080501242.808901,0]
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["ACCP",{"$f":"+c_ACCP_A","v":429156000},{"$f":"+c_ACCP_B","v":431121000},null,"c_ACCP_18",{"$f":"+Hoja1!$C108","v":2443208987.7186999},{"$f":"+Hoja1!$C126","v":2448568721.7186999},18,893.58769844326628,20.137187569326727,86.275113987406741,893.58769844326628,20.137187569326727,0,{"$f":"+(I23*Hoja1!$E$51)+(J23*Hoja1!$E$51)","v":520.54906756137416},997677405039.31165,22527718229.45763,0,null,null,null,null,null,null,null,null,null,null,0,0,1]
["COSTO FIJO",{"$f":"+ACCP","v":243745674},null,null,"c_ACCP_>19",{"$f":"+Hoja1!$C$109","v":2508060260.1599998},{"$f":"+Hoja1!$C$127","v":2513562260.1599998},19,889.11975995017963,20.036501632350376,90.843738417469709,889.11975995017963,20.036501632350376,0,{"$f":"+(I24*Hoja1!$E$51)+(J24*Hoja1!$E$51)","v":517.94632222356734},968236349132.36255,21863036724.978615,0]
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[]
[null,null,null,null,null,null,null,"PARA ESTE PRIMER USO DE LA MOLECULA SE ESPERARIA UNA ESPERANZA DE VIDA DE 19,08 AÑOS. EN ESTE PRIMER TRAYECTO DE 20 AÑOS PARA EL MODELO SE ESPERA UNA PROPORCION DEL 95% DE LA PERSONAS PERMANEZCAN VIVAS A LOS 20 AÑOS"]
["PROFILAXIS EMICIZUMAB"]
[null,null,null,null,null,null,null,null,"Número de pacientes",null,null,"Expectativa de vida",null,null,null,"Costos acumulados"]
[null,"Vivo","Sangrado Articular","Muera",null,"Costo EMIZ","Costo EMIZ",null,"Vivo","Sangrado Articular","Muera","Vivo","Sangrado Articular","Muera","AVAC","Vivo","Vivo con sangrado","Muera"]
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["Sangrado Articular",{"$f":"+EMZ_SA_a_V","v":0.71},{"$f":"+EMZ_SA_a_SA","v":0.28500000000000003},{"$f":"+EMZ_SA_a_M","v":5.0000000000000001E-3},"c_EMZ_02",{"$f":"+Hoja1!$C$56","v":190814910.64269999},{"$f":"+Hoja1!$C$74","v":190877523.54260001},1,{"$f":"+I86*$B$86+J86*$B$87+K86*$B$88","v":994.83999999999992},{"$f":"+I86*$C$86+J86*$C$87+K86*$C$88","v":0.16},{"$f":"+I86*$D$86+J86*$D$87+K86*$D$88","v":5},{"$f":"+I87*1","v":994.83999999999992},{"$f":"+J87*1","v":0.16},{"$f":"+K87*0","v":0},{"$f":"+(I87*Hoja1!$D$51)+('Cálculo de la Cadena'!J87*Hoja1!$D$51)","v":764.45849999999996},{"$f":"+I87*($B$107+F87)/(1+TasaDescuento)^H87","v":411731668596.13672},{"$f":"+J87*($B$107+G87)/(1+TasaDescuento)^H87","v":66228296.768396199},0,null,null,null,null,null,null,null,null,null,null,0.90868640000000001,8.1338600000000025E-2,9.9750000000000012E-3,null,4.5269362763521785,0.3985618523946961,7.4501871253125004E-2]
["Muera",0,0,{"$f":"+EMZ_M_a_M","v":1},"c_EMZ_02",{"$f":"+Hoja1!$C$56","v":190814910.64269999},{"$f":"+Hoja1!C74","v":190877523.54260001},2,{"$f":"+I87*$B$86+J87*$B$87+K87*$B$88","v":989.82022559999984},{"$f":"+I87*$C$86+J87*$C$87+K87*$C$88","v":0.2047744},{"$f":"+I87*$D$86+J87*$D$87+K87*$D$88","v":9.9749999999999996},{"$f":"+I88*1","v":989.82022559999984},{"$f":"+J88*1","v":0.2047744},{"$f":"+K88*0","v":0},{"$f":"+(I88*Hoja1!$D$51)+('Cálculo de la Cadena'!J88*Hoja1!$D$51)","v":760.63620749999984},390146808097.87311,80725355.558156371,0,null,null,null,null,null,null,null,null,null,null,0,0,1,null,0,0,5]
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["Matriz Identidad",1,0,null,"c_EMZ_05",{"$f":"+Hoja1!C59","v":286372613.92519999},{"$f":"+Hoja1!C77","v":286466582.57660002},5,{"$f":"+I90*$B$86+J90*$B$87+K90*$B$88","v":975.02945071396164},{"$f":"+I90*$C$86+J90*$C$87+K90*$C$88","v":0.21930240791289848},{"$f":"+I90*$D$86+J90*$D$87+K90*$D$88","v":24.751246878124995},975.02945071396164,0.21930240791289848,0,{"$f":"+(I91*Hoja1!$D$51)+('Cálculo de la Cadena'!J91*Hoja1!$D$51)","v":749.28361702353618},404989743859.23047,91105934.606165648,0,null,null,null,null,null,null,null,null,null,null,0.96174798417599994,2.332689082400001E-2,1.4925125000000001E-2]
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["Matriz Fundamental",{"$f":"+MINVERSE(B94:C95)","v":199.95525476816167},4.474523183623224E-2,null,"c_EMZ_11",{"$f":"+Hoja1!C65","v":484098930.7802},{"$f":"+Hoja1!C83","v":484257780.20029998},11,946.14136508359957,0.21321472984254899,53.645420186556947,946.14136508359957,0.21321472984254899,0,{"$f":"+(I97*Hoja1!$D$51)+('Cálculo de la Cadena'!J97*Hoja1!$D$51)","v":727.08422367066748},402635818831.83173,90754538.901982889,0]
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["Feiba ",null,null,null,"c_EMZ_15",{"$f":"+Hoja1!C69","v":818701140.23010004},{"$f":"+Hoja1!C87","v":818969784.08179998},15,927.35998628769119,0.20898253063565747,72.431031181672083,927.35998628769119,0.20898253063565747,0,{"$f":"+(I101*Hoja1!$D$51)+('Cálculo de la Cadena'!J101*Hoja1!$D$51)","v":712.65123874312042},473932035186.90021,106828589.8353878,0]
["Feiba ","Si la persona sangra se toma el doble del medicamento",null,null,"c_EMZ_16",{"$f":"+Hoja1!C70","v":935594053.99389994},{"$f":"+Hoja1!C88","v":935901054.4095},16,922.72318635519798,0.20793761903719299,77.068876025763714,922.72318635519798,0.20793761903719299,0,{"$f":"+(I102*Hoja1!$D$51)+('Cálculo de la Cadena'!J102*Hoja1!$D$51)","v":709.08798254940484},498518841806.86676,112371518.41705666,0]
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["Matriz de Costos","Vivo","Sangrado Articular",null,"c_EMZ_18",{"$f":"+Hoja1!C72","v":1024540846.9864},{"$f":"+Hoja1!C90","v":1024877033.8875999},18,913.51902257092036,0.20586344167179252,86.275113987406712,913.51902257092036,0.20586344167179252,0,{"$f":"+(I104*Hoja1!$D$51)+('Cálculo de la Cadena'!J104*Hoja1!$D$51)","v":702.01482992347451},481423835882.16956,108518636.09025468,0]
["Feiba ",429156000,858312000,0,"c_EMZ_>19",{"$f":"+Hoja1!$C$73","v":1051735727.952},{"$f":"+Hoja1!$C$91","v":1052080838.424},19,908.95142745804128,0.20483412448780813,90.843738417469666,908.95142745804128,0.20483412448780813,0,{"$f":"+(I105*Hoja1!$D$51)+('Cálculo de la Cadena'!J105*Hoja1!$D$51)","v":698.50475577385703},465988475635.37811,105039462.05437696,0,null,null,null,null,null,null,null,null,null,null,"de por vida "]
["Total",{"$f":"+c_EMZ_A","v":300495922},{"$f":"+c_EMZ_B","v":300619176},{"$f":"+D105","v":0},"c_EMZ_>19",{"$f":"+Hoja1!$C$73","v":1051735727.952},{"$f":"+Hoja1!$C$91","v":1052080838.424},20,{"$f":"+I105*$B$86+J105*$B$87+K105*$B$88","v":904.40667032074407},{"$f":"+I105*$C$86+J105*$C$87+K105*$C$88","v":0.20380995387231193},{"$f":"+I105*$D$86+J105*$D$87+K105*$D$88","v":95.389519725382314},904.40667032074407,0.20380995387231193,0,{"$f":"+(I106*Hoja1!$D$51)+('Cálculo de la Cadena'!J106*Hoja1!$D$51)","v":695.01223199498781},441579555483.04541,99537394.997776553,0]
["COSTO FIJO",{"$f":"+EMZ","v":243745674},null,null,"c_EMZ_>19",{"$f":"+Hoja1!$C$73","v":1051735727.952},{"$f":"+Hoja1!$C$91","v":1052080838.424},21,899.88463696913834,0.20279090410492798,99.912572126755393,899.88463696913834,0.20279090410492798,0,{"$f":"+(I107*Hoja1!$D$51)+('Cálculo de la Cadena'!J107*Hoja1!$D$51)","v":691.53717083501283},418449197814.88495,94323531.45119381,0]
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[null,null,null,null,"c_EMZ_>19",{"$f":"+Hoja1!$C$73","v":1051735727.952},{"$f":"+Hoja1!$C$91","v":1052080838.424},73,693.40510752539353,0.15626030592121545,306.43863216868181,693.40510752539353,0.15626030592121545,0,{"$f":"+(I159*Hoja1!$D$51)+('Cálculo de la Cadena'!J159*Hoja1!$D$51)","v":532.86319890479911},25503476591.755318,5748793.3756078491,0]
[null,null,null,null,null,null,null,null,{"$f":"+SUM(I86:I159)/$I$5","v":61.967638370609755},1.3649430957910418E-2,12.018712198432191,61.967638370609755,1.3649430957910418E-2,0,47.620223417944437,16697614955.222624,3629065.2012570901,0]
[]
["PROBABILISTICO"]
["PROFILAXIS CASO ACCP"]
[]
[null,null,null,null,null,null,null,null,"Número de pacientes",null,null,"Expectativa de vida",null,null,null,"Costos acumulados"]
[null,"Vivo","Sangrado Articular","Muera",null,"Costo ACCP - V","Costo ACCP SA",null,"Vivo","Sangrado Articular","Muera","Vivo","Sangrado Articular","Muera","AVAC","Vivo","Sangrado Articular","Muera"]
["Vivo",{"$f":"1-C167-D167","v":0.97760000000000002},{"$f":"+Hoja1!D13","v":1.8599999999999998E-2},{"$f":"+Hoja1!D14","v":3.8E-3},"c_ACCP_02",{"$f":"+Hoja1!$D$92","v":385977145},{"$f":"+Hoja1!$D$110","v":512868076},0,1000,0,0,{"$f":"+I167*1","v":1000},{"$f":"+J167*1","v":0},{"$f":"+K167*0","v":0},{"$f":"+I167*Hoja1!$E$51","v":569.69999999999993},{"$f":"I167*($B$186+F167)/(1)^H167","v":576177664000},{"$f":"J167*($B$186+G167)/(1)^H167","v":0},0]
["Sangrado Articular",{"$f":"+Hoja1!D15","v":0.62270000000000003},{"$f":"1-B168-D168","v":0.37299999999999994},{"$f":"+Hoja1!D17","v":4.3E-3},"c_ACCP_02",{"$f":"+Hoja1!$D$92","v":385977145},{"$f":"+Hoja1!$D$110","v":512868076},1,{"$f":"+I167*$B$167+J167*$B$168+K167*$B$169","v":977.6},{"$f":"+I167*$C$167+J167*$C$168+K167*$C$169","v":18.599999999999998},{"$f":"+I167*$D$167+J167*$D$168+K167*$D$169","v":3.8},977.6,18.599999999999998,0,{"$f":"+(I168*Hoja1!$E$51)+(J168*Hoja1!$E$51)","v":567.53513999999996},{"$f":"I168*($B$186+F168)/(1+Hoja1!$D$47)^H168","v":535479878625.72485},{"$f":"J168*($B$186+G168)/(1+$B$171)^H168","v":12431862217.891432},0]
["Muera",0,0,1,"c_ACCP_02",{"$f":"+Hoja1!D92","v":385977145},{"$f":"+Hoja1!D110","v":512868076},2,{"$f":"+I168*$B$167+J168*$B$168+K168*$B$169","v":967.28398000000004},25.12116,7.5948599999999997,{"$f":"+I169*1","v":967.28398000000004},{"$f":"+J169*1","v":25.12116},{"$f":"+K169*0","v":0},{"$f":"+(I169*Hoja1!$E$51)+(J169*Hoja1!$E$51)","v":565.37320825800009},{"$f":"I169*($B$186+F169)/(1+Hoja1!$D$47)^H169","v":503687883042.56244},15962043075.847677,0]
[null,null,null,null,"c_ACCP_03",{"$f":"+Hoja1!D93","v":545780174},{"$f":"+Hoja1!D111","v":582185209},3,961.25976518000004,27.361674707999999,11.378560111999999,961.25976518000004,27.361674707999999,0,{"$f":"+(I170*Hoja1!$E$51)+(J170*Hoja1!$E$51)","v":563.21763430419367},{"$f":"I170*($B$186+F170)/(1+Hoja1!$D$47)^H170","v":607832364933.37744},18157395378.784595,0]
["Tasa de Descuento",{"$f":"Hoja1!D47","v":5.1900000000000002E-2},null,null,"c_ACCP_04",{"$f":"+Hoja1!D94","v":636694581},{"$f":"+Hoja1!D112","v":583311074},4,956.76566128063962,28.085336298431997,15.149002420928399,956.76566128063962,28.085336298431997,0,{"$f":"+(I171*Hoja1!$E$51)+(J171*Hoja1!$E$51)","v":561.06961332079709},{"$f":"I171*($B$186+F171)/(1+Hoja1!$D$47)^H171","v":646186942343.62988},17743881775.615108,0]
["Matriz Identidad",1,0,null,"c_ACCP_05",{"$f":"+Hoja1!D95","v":717690718},{"$f":"+Hoja1!D113","v":719423479},5,952.8228493809869,28.27167173913503,18.905478879878089,952.8228493809869,28.27167173913503,0,{"$f":"+(I172*Hoja1!$E$51)+(J172*Hoja1!$E$51)","v":558.92954868213337},{"$f":"I172*($B$186+F172)/(1+Hoja1!$D$47)^H172","v":671697469286.67554},19968301415.791428,0]
[null,0,1,null,"c_ACCP_06",{"$f":"+Hoja1!D96","v":758287094},{"$f":"+Hoja1!D114","v":891538067},6,949.0843875468122,28.267838557183719,22.647773896004118,949.0843875468122,28.267838557183719,0,{"$f":"+(I173*Hoja1!$E$51)+(J173*Hoja1!$E$51)","v":556.79756321144646},{"$f":"I173*($B$186+F173)/(1+Hoja1!$D$47)^H173","v":664492008281.98291},22571903925.23452,0]
[null,null,null,null,"c_ACCP_07",{"$f":"+Hoja1!D97","v":701790105},{"$f":"+Hoja1!D115","v":886334344},7,945.42728033532194,28.196873390200231,26.375846274477894,945.42728033532194,28.196873390200231,0,{"$f":"+(I174*Hoja1!$E$51)+(J174*Hoja1!$E$51)","v":554.67368037742995},{"$f":"I174*($B$186+F174)/(1+Hoja1!$D$47)^H174","v":591789470097.16223},21301386246.099384,0]
[null,{"$f":"+B172-B167","v":2.2399999999999975E-2},{"$f":"+C172-C167","v":-1.8599999999999998E-2},null,"c_ACCP_08",{"$f":"+Hoja1!D98","v":889126475},{"$f":"+Hoja1!D116","v":815689045},8,941.80790231588844,28.102381188781671,30.089716495329977,941.80790231588844,28.102381188781671,0,{"$f":"+(I175*Hoja1!$E$51)+(J175*Hoja1!$E$51)","v":552.55788851261048},{"$f":"I175*($B$186+F175)/(1+Hoja1!$D$47)^H175","v":678140571816.67078},18858093379.97728,0]
[null,{"$f":"+B173-B168","v":-0.62270000000000003},{"$f":"+C173-C168","v":0.627},null,"c_ACCP_09",{"$f":"+Hoja1!D99","v":1125463536},{"$f":"+Hoja1!D117","v":967346462},9,938.21075807026693,27.999815166491082,33.789426763242112,938.21075807026693,27.999815166491082,0,{"$f":"+(I176*Hoja1!$E$51)+(J176*Hoja1!$E$51)","v":550.45016357298095},{"$f":"I176*($B$186+F176)/(1+Hoja1!$D$47)^H176","v":782844170822.81787},20555294107.782112,0]
[null,null,null,null,"c_ACCP_10",{"$f":"+Hoja1!D100","v":986180638},{"$f":"+Hoja1!D118","v":1159071737},10,934.63032199366694,27.894651157208138,37.475026849125037,934.63032199366694,27.894651157208138,0,{"$f":"+(I177*Hoja1!$E$51)+(J177*Hoja1!$E$51)","v":548.3504772040535},{"$f":"I177*($B$186+F177)/(1+Hoja1!$D$47)^H177","v":662892911475.58521},22692167150.511303,0]
["Matriz Fundamental",{"$f":"+MINVERSE(B175:C176)","v":254.61101771313167},7.5530541139780691,null,"c_ACCP_11",{"$f":"+Hoja1!D101","v":1064758509},{"$f":"+Hoja1!D119","v":1220823325},11,931.06460205660233,27.788828870720838,41.146569072676968,931.06460205660233,27.788828870720838,0,{"$f":"+(I178*Hoja1!$E$51)+(J178*Hoja1!$E$51)","v":546.25879959929603},{"$f":"I178*($B$186+F178)/(1+Hoja1!$D$47)^H178","v":669715509469.01575},22474269830.228527,0]
[null,252.86488154699697,9.0961511910273423,null,"c_ACCP_12",{"$f":"+Hoja1!D102","v":1279797003},{"$f":"+Hoja1!D120","v":1282862263},12,927.51285870833226,27.683034767031675,44.804106524636154,927.51285870833226,27.683034767031675,0,{"$f":"+(I179*Hoja1!$E$51)+(J179*Hoja1!$E$51)","v":544.17510051291481},{"$f":"I179*($B$186+F179)/(1+Hoja1!$D$47)^H179","v":742921762818.02014},22219868976.618008,0]
[null,null,null,null,"c_ACCP_13",{"$f":"+Hoja1!D103","v":1586963813},{"$f":"+Hoja1!D121","v":1946690767},13,923.97479642269627,27.577511140077792,48.447692437226053,923.97479642269627,27.577511140077792,0,{"$f":"+(I180*Hoja1!$E$51)+(J180*Hoja1!$E$51)","v":542.09934961851229},{"$f":"I180*($B$186+F180)/(1+Hoja1!$D$47)^H180","v":850589068190.24402},30525977538.845375,0]
[null,null,null,null,"c_ACCP_14",{"$f":"+Hoja1!D104","v":1809439504},{"$f":"+Hoja1!D122","v":1769177357},14,920.45027716975437,27.472342868711163,52.077379961534632,920.45027716975437,27.472342868711163,0,{"$f":"+(I181*Hoja1!$E$51)+(J181*Hoja1!$E$51)","v":540.03151663591382},{"$f":"I181*($B$186+F181)/(1+Hoja1!$D$47)^H181","v":906378889718.23938},26507668240.718441,0]
[null,null,null,null,"c_ACCP_15",{"$f":"+Hoja1!D105","v":1863330149},{"$f":"+Hoja1!D123","v":1749367094},15,916.93921886549833,27.367559045386692,55.693222089115153,916.93921886549833,27.367559045386692,0,{"$f":"+(I182*Hoja1!$E$51)+(J182*Hoja1!$E$51)","v":537.97157137583122},{"$f":"I182*($B$186+F182)/(1+Hoja1!$D$47)^H182","v":881505274022.32996},24849872267.410736,0]
[null,null,null,null,"c_ACCP_16",{"$f":"+Hoja1!D106","v":2201680114},{"$f":"+Hoja1!D124","v":2312679453},16,913.44155938047345,27.263168994827502,59.295271624699211,913.44155938047345,27.263168994827502,0,{"$f":"+(I183*Hoja1!$E$51)+(J183*Hoja1!$E$51)","v":535.91948375540892},{"$f":"I183*($B$186+F183)/(1+Hoja1!$D$47)^H183","v":972364260061.56458},30368621373.486874,0]
[null,null,null,null,"c_ACCP_17",{"$f":"+Hoja1!D107","v":2677152709},{"$f":"+Hoja1!D125","v":2308373989},17,909.95724378342993,27.159175039547463,62.883581177022769,909.95724378342993,27.159175039547463,{"$f":"+K184*0","v":0},{"$f":"+(I184*Hoja1!$E$51)+(J184*Hoja1!$E$51)","v":533.87522380345024},{"$f":"I184*($B$186+F184)/(1+Hoja1!$D$47)^H184","v":1103917063790.4597},28710657738.636505,0]
["Total",{"$f":"+Hoja1!D35","v":368257322},{"$f":"+Hoja1!D36","v":370975070},null,"c_ACCP_18",{"$f":"+Hoja1!D108","v":2693754760},{"$f":"+Hoja1!D126","v":2449549999},18,906.48621981980739,27.055577024122996,66.458203156069857,906.48621981980739,27.055577024122996,{"$f":"+K185*0","v":0},{"$f":"+(I185*Hoja1!$E$51)+(J185*Hoja1!$E$51)","v":531.83876166198718},{"$f":"I185*($B$186+F185)/(1+Hoja1!$D$47)^H185","v":1051500627107.2296},28726286826.963215,0]
["COSTO FIJO",{"$f":"+Hoja1!D41","v":190200519},null,null,"c_ACCP_>19",{"$f":"+Hoja1!$D$109","v":2105843769},{"$f":"+Hoja1!$D$127","v":2229387844},19,903.02843630876521,26.952373918646295,70.019189772588859,{"$f":"+I186*1","v":903.02843630876521},{"$f":"+J186*1","v":26.952373918646295},{"$f":"+K186*0","v":0},{"$f":"+(I186*Hoja1!$E$51)+(J186*Hoja1!$E$51)","v":529.81006758655633},{"$f":"I186*($B$186+F186)/(1+Hoja1!$D$47)^H186","v":792806204322.79712},24935831989.613342,0]
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[null,null,null,null,null,null,null,null,{"$f":"+SUM(I167:I240)/$I$5","v":62.754324262580582},1.8267744658985769,9.4189012715209177,62.754324262580582,1.8267744658985769,0,36.791851945614575,28318047292.824825,851816807.19484639,0]
[]
["PROFILAXIS CASO EMZ"]
[null,null,null,null,null,null,null,null,"Número de pacientes",null,null,"Expectativa de vida",null,null,null,"Costos acumulados"]
[null,"Vivo","Sangrado Articular","Muera",null,"Costo EMIZ - V","Costo EMIZ - SA",null,"Vivo","Sangrado Articular","Muera","Vivo","Sangrado Articular","Muera","AVAC","Vivo","Sangrado Articular","Muera"]
["Vivo",{"$f":"1-C246-D246","v":0.99489371999999998},{"$f":"Hoja1!D20*Hoja1!D30","v":6.28E-6},{"$f":"+Hoja1!D21","v":5.1000000000000004E-3},"c_EMZ_02",{"$f":"+Hoja1!$D$56","v":211815912},{"$f":"+Hoja1!$D$74","v":196204900},0,1000,0,0,{"$f":"+I246*1","v":1000},{"$f":"+J246*1","v":0},{"$f":"+K246*0","v":0},{"$f":"+(I246*Hoja1!$D$51)","v":768.3},{"$f":"I246*($B$265+F246)/(1)^H246","v":284133936000},{"$f":"J246*($B$265+G246)/(1)^H246","v":0},0]
["Sangrado Articular",{"$f":"+Hoja1!D22","v":0.85029999999999994},{"$f":"1-B247-D247","v":0.14420000000000005},{"$f":"+Hoja1!D24","v":5.4999999999999997E-3},"c_EMZ_02",{"$f":"+Hoja1!$D$56","v":211815912},{"$f":"+Hoja1!$D$74","v":196204900},1,{"$f":"+I246*$B$246+J246*$B$247+K246*$B$248","v":994.89372000000003},{"$f":"+I246*$C$246+J246*$C$247+K246*$C$248","v":6.28E-3},{"$f":"+I246*$D$246+J246*$D$247+K246*$D$248","v":5.1000000000000005},{"$f":"+I247*1","v":994.89372000000003},{"$f":"+J247*1","v":6.28E-3},{"$f":"+K247*0","v":0},{"$f":"+(I247*Hoja1!$D$51)","v":764.376845076},{"$f":"I247*($B$265+F247)/(1+$B$250)^H247","v":268735686439.09299},{"$f":"J247*($B$265+G247)/(1+$B$250)^H247","v":1603121.9343283582},0]
["Muera",0,0,1,"c_EMZ_02",{"$f":"+Hoja1!D56","v":211815912},{"$f":"+Hoja1!D74","v":196204900},2,{"$f":"+I247*$B$246+J247*$B$247+K247*$B$248","v":989.81885397943847},{"$f":"+I247*$C$246+J247*$C$247+K247*$C$248","v":7.1535085616000003E-3},{"$f":"+I247*$D$246+J247*$D$247+K247*$D$248","v":10.173992512000002},{"$f":"+I248*1","v":989.81885397943847},{"$f":"+J248*1","v":7.1535085616000003E-3},{"$f":"+K248*0","v":0},{"$f":"+(I248*Hoja1!$D$51)+('Cálculo de la Cadena'!J248*Hoja1!$D$51)","v":760.48332155303046},254173295142.83154,1736007.3465041213,0]
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["Tasa de Descuento",{"$f":"+Hoja1!D47","v":5.1900000000000002E-2},null,null,"c_EMZ_04",{"$f":"+Hoja1!D58","v":269462973},{"$f":"+Hoja1!D76","v":229702631},4,979.74829237690062,7.2294633270477545E-3,20.244478159772441,979.74829237690062,7.2294633270477545E-3,0,{"$f":"+(I250*Hoja1!$D$51)+('Cálculo de la Cadena'!J250*Hoja1!$D$51)","v":752.74616742984688},273504582410.59799,1783384.0727293631,0]
["Matriz Identidad",1,0,null,"c_EMZ_05",{"$f":"+Hoja1!D59","v":316367324},{"$f":"+Hoja1!D77","v":235121092},5,974.75157047916923,7.1953078878872227E-3,25.241234212942935,974.75157047916923,7.1953078878872227E-3,0,{"$f":"+(I251*Hoja1!$D$51)+('Cálculo de la Cadena'!J251*Hoja1!$D$51)","v":748.90715975419596},294184534408.06995,1717656.1524593225,0]
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["Matriz Fundamental",{"$f":"+MINVERSE(B254:C255)","v":196.07687967790091},1.4388441275733329E-3,null,"c_EMZ_11",{"$f":"+Hoja1!D65","v":543898931},{"$f":"+Hoja1!D83","v":586992544},11,945.30187830388797,6.9783658314750453E-3,54.691143330280632,945.30187830388797,6.9783658314750453E-3,0,{"$f":"+(I257*Hoja1!$D$51)+('Cálculo de la Cadena'!J257*Hoja1!$D$51)","v":726.28079457934541},333875966508.27972,2637088.8582806597,0]
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["Total",{"$f":"+Hoja1!D37","v":440878043},{"$f":"+Hoja1!D38","v":507535286},null,"c_EMZ_18",{"$f":"+Hoja1!D72","v":878577205},{"$f":"+Hoja1!D90","v":944346958},18,912.06654911972737,6.7330174542769607E-3,87.926717862818421,912.06654911972737,6.7330174542769607E-3,0,{"$f":"+(I264*Hoja1!$D$51)+('Cálculo de la Cadena'!J264*Hoja1!$D$51)","v":700.74590266599671},348834157691.39117,2753261.19201033,0]
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[]
[]
[null,"ANÁLISIS DE SENSIBILIDAD DETERMINÍSTICO"]
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[null,"Tornado"]
[null,null,null,null,null,null,null,null,null,"RESULTADOS"]
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[null,null,null,null,null,null,null,null,null,null,null,null,"DIFERENCIAL"]
[null,null,null,null,null,null,null,null,null,null,"Dif Cost",null,"Dif Efec",null,"RICE"]
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[null,"PARÁMETROS",null,null,null,null,null,null,null,null,{"$f":"+'Resultado HT 73Años'!F5","v":-16804189632.422634},null,{"$f":"+'Resultado HT 73Años'!D5","v":12.309483757391284},null,{"$f":"+K14/M14","v":-1365141704.0403895}]
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[null,"Ítem","VALORES DEL PARÁMETRO"]
[null,null,"Mínimo",null,"Máximo",null,"Base",null,null,null,"Mínimo",null,"Máximo",null,"Diferencia"]
[]
[null,"TasaDescuento",0,null,0.12,null,0.05,null,null,null,-6208638977.4899998,null,-433091003.75,null,5775547973.7399998]
[null,"ACCP_V_a_SA",1.2E-2,null,0.02,null,1.6E-2,null,null,null,-2810179679.73,null,-837192527.52999997,null,1972987152.2]
[null,"ACCP_SA_a_V",0.53249999999999997,null,0.88749999999999996,null,0.71,null,null,null,-2700596806.21,null,-855756323.48000002,null,1844840482.73]
[null,"EMZ_V_a_V",0.74612999999999996,null,1,null,0.99483999999999995,null,null,null,-673860544.57000005,null,986693902.34000003,null,1660554446.9100001]
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[null,"ACCP_SA_a_SA",0.21375,null,0.35624999999999996,null,0.28499999999999998,null,null,null,-1771859605.8699999,null,-1132935215.49,null,638924390.38]
[null,"EMZ",{"$f":"+G25*0.75","v":182809255.5},null,{"$f":"G25*1.25","v":304682092.5},null,243745674,null,null,null,-1457885191.0799999,null,-1272398217,null,185486974.08000001]
[null,"ACCP",{"$f":"+G26*0.75","v":182809255.5},null,{"$f":"G26*1.25","v":304682092.5},null,243745674,null,null,null,-1457885191.0799999,null,-1272398217,null,185486974.08000001]
[null,"RR",4.0000000000000001E-3,null,4.3999999999999997E-2,null,0.01,null,null,null,-1385654663.7881956,null,-1256762962.9270029,null,128891700.8611927]
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[null,"EMZ_SA_a_SA",0.21375000000000002,null,0.35625000000000007,null,0.28500000000000003,null,null,null,-1368109759.1500001,null,-1361556280.98,null,6553478.1700000763]
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[null,"ACCP_SA_a_M",3.7499999999999999E-3,null,6.2500000000000003E-3,null,5.0000000000000001E-3,null,null,null,-1365141704.04,null,-1365141704.04,null,0]
[null,"ACCP_M_a_M",0.75,null,1,null,1,null,null,null,-1365141704.04,null,-1365141704.04,null,0]
[null,"EMZ_V_a_M",3.7499999999999999E-3,null,6.2500000000000003E-3,null,5.0000000000000001E-3,null,null,null,-1365141704.04,null,-1365141704.04,null,0]
[null,"EMZ_SA_a_M",3.7499999999999999E-3,null,6.2500000000000003E-3,null,5.0000000000000001E-3,null,null,null,-1365141704.04,null,-1365141704.04,null,0]
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{"sheet":"Resultado HT 73Años","index":3,"n_rows":11,"n_cols":11,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
[]
["Caso base horizonte temporal de 73 años"]
[null,"Alternativas","Utilidad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO",null,null,"EMICIZUMAB ES DOMINANTE CON RESPECTO A ACCP PORQUE ES MAS EFECTIVA Y MENOS COSTOSA QUE EL COMPARADOR, PERO NO COSTOEFECTIVA CON RESPECTO AL UMBRAL"]
[null,"EMZ",{"$f":"+'Cálculo de la Cadena'!O160","v":47.620223417944437},null,{"$f":"+SUM('Cálculo de la Cadena'!P160:R160)","v":16701244020.423882},null,null,{"$f":"+E4/C4","v":350717464.59153432}]
[null,"ACCP",{"$f":"+'Cálculo de la Cadena'!O79","v":35.310739660553153},{"$f":"+C4-C5","v":12.309483757391284},{"$f":"+SUM('Cálculo de la Cadena'!P79:R79)","v":33505433652.846516},{"$f":"+E4-E5","v":-16804189632.422634},{"$f":"+(F5/D5)","v":-1365141704.0403895},{"$f":"+E5/C5","v":948873741.3868618}]
[]
[]
["Probabilístico"]
[null,"Alternativas","Utildiad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO"]
[null,"EMZ",{"$f":"+SUM('Cálculo de la Cadena'!O320)","v":47.456828686178255},null,{"$f":"+SUM('Cálculo de la Cadena'!P320:R320)","v":13417151003.222111},null,null,{"$f":"+E10/C10","v":282723295.56504565}]
[null,"ACCP",{"$f":"+SUM('Cálculo de la Cadena'!O241)","v":36.791851945614575},{"$f":"+C10-C11","v":10.664976740563681},{"$f":"+SUM('Cálculo de la Cadena'!P241:R241)","v":29169864100.019672},{"$f":"+E10-E11","v":-15752713096.797562},{"$f":"+(F11/D11)","v":-1477050862.8380728},{"$f":"+E11/C11","v":792834895.70294905}]

{"sheet":"Resultado HT 5Años","index":4,"n_rows":11,"n_cols":11,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
[]
["Caso base horizonte temporal de 5 Años"]
[null,"Alternativas","Utilidad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO",null,null,"EMICIZUMAB ES DOMINANTE CON RESPECTO A ACCP PORQUE ES MAS EFECTIVA Y MENOS COSTOSA QUE EL COMPARADOR, PERO NO COSTOEFECTIVA CON RESPECTO AL UMBRAL"]
[null,"EMZ",{"$f":"+SUM('Cálculo de la Cadena'!O86:O90)/'Cálculo de la Cadena'!I86","v":3.8032765952926866},null,{"$f":"+SUM('Cálculo de la Cadena'!P86:R90)/1000","v":2035036169.475215},null,null,{"$f":"+E4/C4","v":535074459.74189156}]
[null,"ACCP",{"$f":"SUM('Cálculo de la Cadena'!O5:O9)/'Cálculo de la Cadena'!I5","v":2.8201570692935629},{"$f":"+C4-C5","v":0.98311952599912367},{"$f":"+SUM('Cálculo de la Cadena'!P5:Q9)/'Cálculo de la Cadena'!I5","v":3333216261.5305901},{"$f":"+E4-E5","v":-1298180092.0553751},{"$f":"+(F5/D5)","v":-1320470255.8786654},{"$f":"+E5/C5","v":1181925750.8113}]
[]
[]
["Probabilístico"]
[null,"Alternativas","Utildiad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO"]
[null,"EMZ",{"$f":"SUM('Cálculo de la Cadena'!O246:O250)/'Cálculo de la Cadena'!I246","v":3.8025111884735714},null,{"$f":"SUM('Cálculo de la Cadena'!P246:R250)/'Cálculo de la Cadena'!I246","v":1314486647.9363022},null,null,{"$f":"+E10/C10","v":345689094.07048237}]
[null,"ACCP",{"$f":"SUM('Cálculo de la Cadena'!O167:O171)/'Cálculo de la Cadena'!I167","v":2.8268955958829904},{"$f":"+C10-C11","v":0.97561559259058095},{"$f":"SUM('Cálculo de la Cadena'!P167:R171)/'Cálculo de la Cadena'!I167","v":2933659915.3934336},{"$f":"+E10-E11","v":-1619173267.4571314},{"$f":"+(F11/D11)","v":-1659642670.4883761},{"$f":"+E11/C11","v":1037767337.310204}]

{"sheet":"Resultado HT 16Años","index":5,"n_rows":11,"n_cols":11,"rows_kept":11,"cut":false,"hidden":false,"merged":[]}
[]
["Caso base horizonte temporal de 5 Años"]
[null,"Alternativas","Utilidad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO",null,null,"EMICIZUMAB ES DOMINANTE CON RESPECTO A ACCP PORQUE ES MAS EFECTIVA Y MENOS COSTOSA QUE EL COMPARADOR, PERO NO COSTOEFECTIVA CON RESPECTO AL UMBRAL"]
[null,"EMZ",{"$f":"+SUM('Cálculo de la Cadena'!O86:O101)/'Cálculo de la Cadena'!I86","v":11.842403490118846},null,{"$f":"+SUM('Cálculo de la Cadena'!P86:R101)/1000","v":6789269677.8749762},null,null,{"$f":"+E4/C4","v":573301668.32601666}]
[null,"ACCP",{"$f":"SUM('Cálculo de la Cadena'!O5:O20)/'Cálculo de la Cadena'!I5","v":8.7812277343755198},{"$f":"+C4-C5","v":3.0611757557433261},{"$f":"+SUM('Cálculo de la Cadena'!P5:R20)/'Cálculo de la Cadena'!I5","v":12471628639.940243},{"$f":"+E4-E5","v":-5682358962.0652666},{"$f":"+(F5/D5)","v":-1856266812.3201096},{"$f":"+E5/C5","v":1420260243.4643688}]
[]
[]
["Probabilístico"]
[null,"Alternativas","Utildiad Esperada","Utilidad Incremental","Costos Esperados","Costo Incremental","RICE","COSTO POR AVAC GANADO"]
[null,"EMZ",{"$f":"SUM('Cálculo de la Cadena'!O246:O261)/'Cálculo de la Cadena'!I246","v":11.83360286651023},null,{"$f":"SUM('Cálculo de la Cadena'!P246:R261)/'Cálculo de la Cadena'!I246","v":5069604657.1060696},null,null,{"$f":"+E10/C10","v":428407536.9347859}]
[null,"ACCP",{"$f":"SUM('Cálculo de la Cadena'!O167:O182)/'Cálculo de la Cadena'!I167","v":8.8591912551861132},{"$f":"+C10-C11","v":2.9744116113241166},{"$f":"SUM('Cálculo de la Cadena'!P167:R182)/'Cálculo de la Cadena'!I167","v":11289151824.471397},{"$f":"+E10-E11","v":-6219547167.3653278},{"$f":"+(F11/D11)","v":-2091017646.5444124},{"$f":"+E11/C11","v":1274286952.3064876}]

{"sheet":"Simulacion","index":7,"n_rows":47,"n_cols":17,"rows_kept":47,"cut":false,"hidden":false,"merged":[[15,8,15,9],[4,0,4,16],[6,1,7,1],[6,2,7,2],[8,8,8,9],[8,10,8,11]]}
[]
[]
[]
[]
["ANÁLISIS DE SENSIBILIDAD PROBABILÍSTICO"]
[]
[null,"Número de simulaciones",30]
[]
["Resultados ",null,null,null,null,null,null,null,"Beneficio monetario",null,"Probabillidad de mayor beneficio neto",null,null,null,"Curva de aceptabilidad"]
[null,"AVG EMZ","Costo EMZ","AVG ACCP","Costo ACCP","AVG incr","Costo incr","RICE","Tratamiento EMZ","Tratamiento \nACCP","Tratamiento\n EMZ","Tratamiento \nACCP",null,null,"Cratio","Tratamiento \nEMZ","Tratamiento \nACCP"]
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["Promedio",{"$f":"AVERAGE(B18:B1017)","v":47.503427833699789},{"$f":"AVERAGE(C18:C1017)","v":13453391047.438343},35.228523941365872,32488927323.85133,12.274903892333917,-19035536276.412983,-1549677586.6251609,{"$f":"AVERAGE(I18:I1017)","v":1886683722300.5535},{"$f":"AVERAGE(J18:J1017)","v":1376652030330.7837},{"$f":"AVERAGE(K18:K1017)","v":1},{"$f":"AVERAGE(L18:L1017)","v":0},null,null,"umbral"]
["Desviación",{"$f":"STDEV(B18:B1017)","v":1.189886334826491},1093607103.4908795,0.87129651440882139,2181327098.990468,0.31919418373122005,2242394747.7954144,168578369.06844509,{"$f":"STDEV(I18:I1017)","v":47430838241.30883},{"$f":"STDEV(J18:J1017)","v":33694440404.834229},{"$f":"STDEV(K18:K1017)","v":0},{"$f":"STDEV(L18:L1017)","v":0}]
["Mínimo",{"$f":"MIN(B18:B1017)","v":45.709204180560157},11655047027.137493,33.91223450084982,28954796094.388947,11.796969679710337,-23824989505.340675,-1869174804.5500078,{"$f":"MIN(I18:I1017)","v":1816375647258.1509},{"$f":"MIN(J18:J1017)","v":1324183287179.3535},{"$f":"MIN(K18:K1017)","v":1},{"$f":"MIN(L18:L1017)","v":0}]
["Máximo",{"$f":"MAX(B18:B1017)","v":49.296629902863231},15459719631.906527,36.553937526406216,36767825682.526199,12.746976553049713,-14749203046.169992,-1236779003.1801565,{"$f":"MAX(I18:I1017)","v":1958986024117.3018},{"$f":"MAX(J18:J1017)","v":1430765107203.9402},{"$f":"MAX(K18:K1017)","v":1},{"$f":"MAX(L18:L1017)","v":0}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,"rango va de 25 MM hasta los 100.000 MM"]
["Número de simulación","AVG EMZ","Costo EMZ","AVG ACCP","Costo ACCP","AVG incr","Costo incr","RICE","Tratamiento EMZ","Tratamiento \nACCP","Tratamiento\n EMZ","Tratamiento \nACCP",null,null,"Disponibilidad a pagar","Tratamiento \nEMZ","Tratamiento \nACCP"]
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[2,48.616945447545653,12195343633.72286,36.064363558525606,33398203594.344086,12.552581889020047,-21202859960.621223,-1689123412.8627927,1932482474268.1033,1409176338746.6802,1,0,null,{"$f":"+(O19-O18)/2","v":1051960368.5915791},{"$f":"+($O$37-$O$18)/19+O18","v":2129426730.7031581},1,0]
[3,46.021235781558744,14289084807.856985,34.167334415203626,29038287854.026978,11.853901366355117,-14749203046.169992,-1244248841.8228786,1826560346454.4929,1337655088754.1182,1,0,null,null,4233347467.8863163,1,0]
[4,46.176725328548471,13690680064.375183,34.242408110810949,33088164831.943401,11.934317217737522,-19397484767.568218,-1625353542.5334995,1833378333077.5637,1336608159600.4946,1,0,null,null,6337268205.0694742,1,0]
[5,49.296629902863231,14980139999.066179,36.553937526406216,35906214150.042824,12.742692376457015,-20926074150.976646,-1642201940.7483289,1956885056115.4631,1426251286906.2058,1,0,null,null,8441188942.2526321,1,0]
[6,48.954998488158843,14321140196.921677,36.306835572377096,35518768913.144661,12.648162915781747,-21197628716.222984,-1675945262.3569262,1943878799329.4321,1416754653981.939,1,0,null,null,10545109679.435791,1,0]
[7,45.709204180560157,11992519964.255283,33.91223450084982,32306092854.639481,11.796969679710337,-20313572890.384197,-1721931431.7067039,1816375647258.1509,1324183287179.3535,1,0,null,null,12649030416.61895,1,0]
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{"sheet":" Simulaciones de Montecarlo","index":10,"n_rows":59,"n_cols":6,"rows_kept":59,"cut":false,"hidden":false,"merged":[[4,0,4,8],[6,1,6,2],[6,3,6,4],[6,5,7,5]]}
[]
[]
[]
[]
["ANÁLISIS DE SENSIBILIDAD PROBABILÍSTICO"]
[]
["Estimación Montecarlo",{"$f":"+#REF!","v":{"$error":"#REF!"}},null,{"$f":"+#REF!","v":{"$error":"#REF!"}},null,"RICE"]
["Valor simulación","Costos ","Hospitalizaciones","Costos ","Hospitalizaciones"]
["Valor simulación",{"$f":"+#REF!","v":{"$error":"#REF!"}},{"$f":"+#REF!","v":{"$error":"#REF!"}},{"$f":"+#REF!","v":{"$error":"#REF!"}},{"$f":"+#REF!","v":{"$error":"#REF!"}},{"$f":"+#REF!","v":{"$error":"#REF!"}}]
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