Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/11564
Título : High expression of antiviral proteins in mucosa from individuals exhibiting resistance to human immunodeficiency virus
Autor : Taborda Vanegas, Natalia Andrea
González Diaz, Sandra Milena
Feria Garzón, Manuel Gerónimo
Arcia Anaya, Eliuth David
Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Ruge, María Teresa
metadata.dc.subject.*: Amidohidrolasa
Cohort Studies
HIV Infections
ARN Mensajero
Adenovirus humanos
Virus Replication
Fecha de publicación : 2015
Citación : Gonzalez SM, Taborda NA, Feria MG, Arcia D, Aguilar-Jiménez W, Zapata W, Rugeles MT. High Expression of Antiviral Proteins in Mucosa from Individuals Exhibiting Resistance to Human Immunodeficiency Virus. PLoS One. 2015 Jun 19;10(6):e0131139
Resumen : Several soluble factors have been reported to have the capacity of inhibiting HIV replication at different steps of the virus life cycle, without eliminating infected cells and through enhancement of specific cellular mechanisms. Yet, it is unclear if these antiviral factors play a role in the protection from HIV infection or in the control of viral replication. Here we evaluated two cohorts: i) one of 58 HIV-exposed seronegative individuals (HESNs) who were compared with 59 healthy controls (HCs), and ii) another of 13 HIV-controllers who were compared with 20 HIV-progressors. Peripheral blood, oral and genital mucosa and gut-associated lymphoid tissue (GALT) samples were obtained to analyze the mRNA expression of ELAFIN, APOBEC3G, SAMHD1, TRIM5α, RNase 7 and SerpinA1 using real-time PCR. RESULTS: HESNs exhibited higher expression of all antiviral factors in peripheral blood mononuclear cells (PBMCs), oral or genital mucosa when compared with HCs. Furthermore, HIV-controllers exhibited higher levels of SerpinA1 in GALT. CONCLUSIONS: These findings suggest that the activity of these factors is compartmentalized and that these proteins have a predominant role depending on the tissue to avoid the infection, reduce the viral load and modulate the susceptibility to HIV infection.
ISSN : 19326203
metadata.dc.identifier.doi: 10.1371/journal.pone.0131139
Aparece en las colecciones: Instituto de Investigaciones Médicas

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