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dc.contributor.authorAgudelo Ochoa, Gloria María-
dc.contributor.authorPulgarín Zapata, Isabel Cristina-
dc.contributor.authorVelásquez Rodríguez, Claudia María-
dc.contributor.authorDuque Ramírez, Mauricio-
dc.contributor.authorNaranjo Cano, Mauricio-
dc.contributor.authorQuintero Ortiz, Mónica M.-
dc.contributor.authorLara Guzmán, Oscar Javier-
dc.contributor.authorMuñoz Durango, Katalina-
dc.date.accessioned2019-08-22T15:06:04Z-
dc.date.available2019-08-22T15:06:04Z-
dc.date.issued2016-
dc.identifier.citationAgudelo-Ochoa GM, Pulgarín-Zapata IC, Velásquez-Rodriguez CM, Duque-Ramírez M, Naranjo-Cano M, et al. Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial. Journal Nutr, 2016; 146(3): 524-31.es_ES
dc.identifier.issn15416100-
dc.identifier.issn00223166 E-
dc.identifier.urihttp://hdl.handle.net/10495/11712-
dc.description.abstractBackground: Coffee, a source of antioxidants, has controversial effects on cardiovascular health. Objective: We evaluated the bioavailability of chlorogenic acids (CGAs) in 2 coffees and the effects of their consumption on the plasma antioxidant capacity (AC), the serum lipid profile, and the vascular function in healthy adults. Methods: Thirty-eight men and 37 women with a mean 6 SD age of 38.5 6 9 y and body mass index of 24.1 6 2.6 kg/m2 were randomly assigned to 3 groups: a control group that did not consume coffee or a placebo and 2 groups that consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or high (HCCGA; 780 mg) CGA content. Both were low in diterpenes (0.83 mg/d) and caffeine (193 mg/d). Plasma caffeic and ferulic acid concentrations were measured by GC, and the plasma AC was evaluated with use of the ferric-reducing antioxidant power method. The serum lipid profile, nitric oxide (NO) plasma metabolites, vascular endothelial function (flow-mediated dilation; FMD), and blood pressure (BP) were evaluated.Results: After coffee consumption (1 h and 8 wk), caffeic and ferulic acid concentrations increased in the coffee-drinking groups, although the values of the 2 groups were significantly different (P < 0.001); caffeic and ferulic acid concentrations were undetectable in the control group. At 1 h after consumption, the plasma AC in the control group was significantly lower than the baseline value (22%) and significantly increased in the MCCGA (6%) and HCCGA (5%) groups (P < 0.05). After 8 wk, no significant differences in the lipid, FMD, BP, or NO plasma metabolite values were observed between the groups. Conclusions: Both coffees, which contained CGAs and were low in diterpenes and caffeine, provided bioavailable CGAs and had a positive acute effect on the plasma AC in healthy adults and no effect on blood lipids or vascular function. The group that did not drink coffee showed no improvement in serum lipid profile, FMD, BP, or NO plasma metabolites. This trial was registered at registroclinico.sld.cu as RPCEC00000168.es_ES
dc.format.extent524-531es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenes_ES
dc.publisherOxford University Presses_ES
dc.type.hasversioninfo:eu-repo/semantics/publishedVersiones_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.sourceinstname: Universidad de Antioquiaes_ES
dc.sourcereponame: Repositorio Institucional Universidad de Antioquiaes_ES
dc.sourceThe Journal of Nutritiones_ES
dc.subjectCardiovascular diseasees_ES
dc.subjectChlorogenic acidses_ES
dc.subjectPhenolic acidses_ES
dc.subjectOxidative stresses_ES
dc.subjectDiterpeneses_ES
dc.subjectCaffeinees_ES
dc.subjectFlow-mediated dilationes_ES
dc.subjectCholesteroles_ES
dc.titleCoffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled triales_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.publisher.groupAlimentación y Nutrición Humanaes_ES
dc.relation.volumen143es_ES
dc.relation.numero3es_ES
dc.source.tituloRevistaAbreviadaJ Nutres_ES
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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