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dc.contributor.authorArias Sierra, Andrés Augusto-
dc.contributor.authorMatute Yepes, Juan David-
dc.contributor.authorCrotzer, Victoria L.-
dc.contributor.authorZhao, Heng-
dc.contributor.authorQuilliam, Lawrence A.-
dc.contributor.authorDinauer, Mary C.-
dc.contributor.authorBlum, Janice S.-
dc.date.accessioned2023-03-29T16:58:57Z-
dc.date.available2023-03-29T16:58:57Z-
dc.date.issued2012-
dc.identifier.citationCrotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol. 2012 Oct 15;189(8):3800-4. doi: 10.4049/jimmunol.1103080.spa
dc.identifier.issn0022-1767-
dc.identifier.urihttps://hdl.handle.net/10495/34336-
dc.description.abstractABSTRACT: Phagocyte NADPH oxidase plays a key role in pathogen clearance via reactive oxygen species (ROS) production. Defects in oxidase function result in chronic granulomatous disease with hallmark recurrent microbial infections and inflammation. The oxidase’s role in the adaptive immune response is not well understood. Class II presentation of cytoplasmic and exogenous Ag to CD4+ T cells was impaired in human B cells with reduced oxidase p40phox subunit expression. Naturally arising mutations, which compromise p40phox function in a chronic granulomatous disease patient, also perturbed class II Ag presentation and intracellular ROS production. Reconstitution of patient B cells with a wild-type, but not a mutant, p40phox allele restored exogenous Ag presentation and intracellular ROS generation. Remarkably, class II presentation of epitopes from membrane Ag was robust in p40phox-deficient B cells. These studies reveal a role for NADPH oxidase and p40phox in skewing epitope selection and T cell recognition of self Ag.spa
dc.format.extent5spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherAsociación Estadounidense de Inmunólogosspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleCutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cellsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupInmunodeficiencias Primariasspa
dc.publisher.groupInmunomodulaciónspa
dc.identifier.doi10.4049/jimmunol.1103080-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1550-6606-
oaire.citationtitleJournal of Immunologyspa
oaire.citationstartpage3800spa
oaire.citationendpage3804spa
oaire.citationvolume189spa
oaire.citationissue8spa
thesis.degree.disciplinesin facultad - programaspa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeBaltimore, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsB-Lymphocytes-
dc.subject.decsLinfocitos B-
dc.subject.decsNADPH Oxidases-
dc.subject.decsNADPH Oxidasas-
dc.subject.decsB-Cell Activating Factor-
dc.subject.decsFactor Activador de Células B-
dc.subject.decsGenes, MHC Class II-
dc.subject.decsGenes MHC Clase II-
dc.subject.decsB-Cell Maturation Antigen-
dc.subject.decsAntígeno de Maduración de Linfocitos B-
dc.description.researchgroupidCOL0012426spa
dc.description.researchgroupidCOL0038389spa
dc.relation.ispartofjournalabbrevJ. Immunol.spa
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