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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Arias Sierra, Andrés Augusto | - |
dc.contributor.author | Matute Yepes, Juan David | - |
dc.contributor.author | Crotzer, Victoria L. | - |
dc.contributor.author | Zhao, Heng | - |
dc.contributor.author | Quilliam, Lawrence A. | - |
dc.contributor.author | Dinauer, Mary C. | - |
dc.contributor.author | Blum, Janice S. | - |
dc.date.accessioned | 2023-03-29T16:58:57Z | - |
dc.date.available | 2023-03-29T16:58:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Crotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol. 2012 Oct 15;189(8):3800-4. doi: 10.4049/jimmunol.1103080. | spa |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://hdl.handle.net/10495/34336 | - |
dc.description.abstract | ABSTRACT: Phagocyte NADPH oxidase plays a key role in pathogen clearance via reactive oxygen species (ROS) production. Defects in oxidase function result in chronic granulomatous disease with hallmark recurrent microbial infections and inflammation. The oxidase’s role in the adaptive immune response is not well understood. Class II presentation of cytoplasmic and exogenous Ag to CD4+ T cells was impaired in human B cells with reduced oxidase p40phox subunit expression. Naturally arising mutations, which compromise p40phox function in a chronic granulomatous disease patient, also perturbed class II Ag presentation and intracellular ROS production. Reconstitution of patient B cells with a wild-type, but not a mutant, p40phox allele restored exogenous Ag presentation and intracellular ROS generation. Remarkably, class II presentation of epitopes from membrane Ag was robust in p40phox-deficient B cells. These studies reveal a role for NADPH oxidase and p40phox in skewing epitope selection and T cell recognition of self Ag. | spa |
dc.format.extent | 5 | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.publisher | Asociación Estadounidense de Inmunólogos | spa |
dc.type.hasversion | info:eu-repo/semantics/publishedVersion | spa |
dc.rights | info:eu-repo/semantics/openAccess | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.5/co/ | * |
dc.title | Cutting Edge: NADPH Oxidase Modulates MHC Class II Antigen Presentation by B Cells | spa |
dc.type | info:eu-repo/semantics/article | spa |
dc.publisher.group | Inmunodeficiencias Primarias | spa |
dc.publisher.group | Inmunomodulación | spa |
dc.identifier.doi | 10.4049/jimmunol.1103080 | - |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
dc.identifier.eissn | 1550-6606 | - |
oaire.citationtitle | Journal of Immunology | spa |
oaire.citationstartpage | 3800 | spa |
oaire.citationendpage | 3804 | spa |
oaire.citationvolume | 189 | spa |
oaire.citationissue | 8 | spa |
thesis.degree.discipline | sin facultad - programa | spa |
dc.rights.creativecommons | https://creativecommons.org/licenses/by-nc-nd/4.0/ | spa |
dc.publisher.place | Baltimore, Estados Unidos | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
dc.type.redcol | https://purl.org/redcol/resource_type/ART | spa |
dc.type.local | Artículo de investigación | spa |
dc.subject.decs | B-Lymphocytes | - |
dc.subject.decs | Linfocitos B | - |
dc.subject.decs | NADPH Oxidases | - |
dc.subject.decs | NADPH Oxidasas | - |
dc.subject.decs | B-Cell Activating Factor | - |
dc.subject.decs | Factor Activador de Células B | - |
dc.subject.decs | Genes, MHC Class II | - |
dc.subject.decs | Genes MHC Clase II | - |
dc.subject.decs | B-Cell Maturation Antigen | - |
dc.subject.decs | Antígeno de Maduración de Linfocitos B | - |
dc.description.researchgroupid | COL0012426 | spa |
dc.description.researchgroupid | COL0038389 | spa |
dc.relation.ispartofjournalabbrev | J. Immunol. | spa |
Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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AriasAndres_2012_NADPHAntigenPresentation.pdf | Artículo de revista | 906.96 kB | Adobe PDF | Visualizar/Abrir |
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