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dc.contributor.authorJaimes Gualdrón, Tania-
dc.contributor.authorFlórez Álvarez, Lizdany-
dc.contributor.authorRojano, Benjamín Alberto-
dc.contributor.authorRugeles López, María Teresa-
dc.contributor.authorZapata Builes, Wildeman-
dc.date.accessioned2023-06-20T14:49:17Z-
dc.date.available2023-06-20T14:49:17Z-
dc.date.issued2022-
dc.identifier.citationJaimes-Gualdrón, Tania & Florez-Alvarez, Lizdany & Zapata Cardona, María & Rojano, Benjamin & Rugeles, María & Zapata, Wildeman. (2022). Corozo (Bactris guineensis) fruit extract has antiviral activity in vitro against SARS-CoV-2. Functional Foods in Health and Disease. 12. 543. 10.31989/ffhd.v12i9.918.spa
dc.identifier.issn2160-3855-
dc.identifier.urihttps://hdl.handle.net/10495/35562-
dc.description.abstractABSTRACT: Background: Given the current COVID-19 pandemic, numerous drug development studies are being carried out for the treatment and control of this disease. This study aimed to evaluate the in vitro antiviral potential of Corozo fruit extract (Bactris guineensis) against SARS-CoV-2. Methods: Corozo extract (CE) was prepared from the pulp of mature Corozo fruits. The total content of phenols, flavonoids, and anthocyanins in the extracts was determined using the Folin-Ciocalteu, aluminum chloride, and pH differential methods, respectively. The cytotoxicity on Vero E6 cells was evaluated by MTT assay. Antiviral activity was evaluated by pre-post-treatment using a Colombian isolate of SARS-CoV-2. Viral titer was quantified by plaque assay. Results: Anthocyanin concentration of CE was 144.95 ± 10.3 mg cyanidin-3-glucoside/L. The cytotoxicity of CE on Vero E6 was lower to 20 % at 15.6 g/L. Corozo extract inhibited SARS-CoV-2 at 15.6, 7.8, 3.9 and 1.9 g/L with inhibition percentages of 88.2%, 84%, 59.6% and 56.3%, respectively. Conclusion: This is the first report on the in vitro antiviral effect of Corozo fruit extract against SARS-CoV-2. Since this is a natural product, proven safe for consumption, in the future and with further studies, it could be considered an important functional food that can be useful in preventing strategies to fight against COVID-19.spa
dc.format.extent13spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherFunctional Food Center, Inc.spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/co/*
dc.titleCorozo (Bactris guineensis) fruit extract has antiviral activity in vitro against SARS-CoV-2spa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupInmunovirologíaspa
dc.identifier.doi10.31989/ffhd.v12i9.918-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2378-7007-
oaire.citationtitleFunctional Food in Health and Diseasespa
oaire.citationstartpage534spa
oaire.citationendpage546spa
oaire.citationvolume12spa
oaire.citationissue9spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc/4.0/spa
oaire.fundernameUniversidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODIspa
dc.publisher.placeEstados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsSARS-CoV-2-
dc.subject.decsAntivirales-
dc.subject.decsAntiviral Agents-
dc.subject.decsArecaceae-
dc.subject.decsMedicina Tradicional-
dc.subject.decsMedicine, Traditional-
dc.subject.decsFrutas-
dc.subject.decsFruit-
dc.subject.decsCOVID-19-
dc.description.researchgroupidCOL0012444spa
dc.relation.ispartofjournalabbrevFFHDspa
oaire.funderidentifier.rorRoR:048jthh02-
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