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Título : | Evidence for a Role of the NOS1AP (CAPON) Gene in Schizophrenia and Its Clinical Dimensions: An Association Study in a South American Population Isolate |
Autor : | Arbeláez Montoya, María Patricia García Valencia, Jenny Restrepo, Gabriel Jaime López Jaramillo, Carlos Alberto Palacio Acosta, Carlos Alberto Restrepo, Margarita Bedoya Berrío, Gabriel de Jesús Ospina Duque, Jorge Ruíz Linares, Andrés Kremeyer, Barbara Kymäläinen, Hanna Wratten, Naomi Miranda, Ana Lucía Brzustowicz, Linda M. |
metadata.dc.subject.*: | Esquizofrenia Schizophrenia Estudios de Asociación Genética Genetic Association Studies Marcadores Genéticos Genetic Markers Predisposición Genética a la Enfermedad Genetic Predisposition to Disease Proteínas Adaptadoras Transductoras de Señales Adaptor Proteins, Signal Transducing Secuencia de Bases Base Sequence Estudio de Asociación del Genoma Completo Genome-Wide Association Study Polimorfismo de Nucleótido Simple Polymorphism, Single Nucleotide |
Fecha de publicación : | 2009 |
Editorial : | Karger |
Citación : | Kremeyer B, García Valencia J, Kymäläinen H, Wratten N, Restrepo GJ, Palacio Acosta CA, et al. Evidence for a role of the NOS1AP (CAPON) gene in schizophrenia and its clinical dimensions: an association study in a South American population isolate. Human heredity, [Internet]. 2009 [citado día mes año];67(3):163-173. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868919/ |
Resumen : | ABSTRACT: Recent studies have implicated a region on chromosome 1q21-23, including the NOS1AP gene, in susceptibility to schizophrenia. However, replication studies have been inconsistent, a fact that could partly relate to the marked psychopathological heterogeneity of schizophrenia. The aim of this study is to evaluate association of polymorphisms in the NOS1AP gene region to schizophrenia, in patients from a South American population isolate, and to assess if these variants are associated with specific clinical dimensions of the disorder. Methods: We genotyped 24 densely spaced SNPs in the NOS1AP gene region in a schizophrenia trio sample. The transmission disequilibrium test (TDT) was applied to single marker and haplotype data. Association to clinical dimensions (identified by factor analysis) was evaluated using a quantitative transmission disequilibrium test (QTDT). Results: We found significant association between eight SNPs in the NOS1AP gene region to schizophrenia (minimum p value = 0.004). The QTDT analysis of clinical dimensions revealed an association to a dimension consisting mainly of negative symptoms (minimum p value 0.001). Conclusions: Our findings are consistent with a role for NOS1AP in susceptibility to schizophrenia, especially for the ‘negative syndrome’ of the disorder.. |
metadata.dc.identifier.eissn: | 1423-0062 |
ISSN : | 0001-5652 |
metadata.dc.identifier.doi: | 10.1159/000181154 |
Aparece en las colecciones: | Artículos de Revista en Salud Pública |
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Fichero | Descripción | Tamaño | Formato | |
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ArbelaezMaria_2009_ EvidenceRoleNOS1AP.pdf | Artículo de investigación | 184.99 kB | Adobe PDF | Visualizar/Abrir |
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