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dc.contributor.authorRojas Camargo, John Jairo-
dc.contributor.authorZuluaga, Carlos-
dc.contributor.authorCadavid, Andrés-
dc.date.accessioned2023-10-10T19:54:09Z-
dc.date.available2023-10-10T19:54:09Z-
dc.date.issued2015-
dc.identifier.citationRojas, John & Zuluaga, Carlos & Cadavid, Andres. (2015). Effect of Reprocessing and Excipient Characteristics on Ibuprofen Tablet Properties. Tropical Journal of Pharmaceutical Research. 14. 1145. 10.4314/tjpr.v14i7.4.spa
dc.identifier.issn1596-5996-
dc.identifier.urihttps://hdl.handle.net/10495/36871-
dc.description.abstractABSTRACT: Purpose: To determine excipient and ibuprofen:excipient mixture sensitivity to reprocessing produced by either direct compression or wet granulation. Methods: The effect of excipient type, technology and reprocessing on flow, compressibility and compactibility was assessed using and 8x2x2 factorial design. Design Expert® v.8.01 software was employed for data analysis. Pure excipients were processed by direct compression, while the ibuprofen:excipient mixtures were processed by wet granulation. Once compacts were produced, they were milled and reprocessed using the same technologies, respectively. Excipient properties such as particle size, porosity and densities were also evaluated. Results: For most excipients, reprocessing caused a 20 – 50 % decrease in particle size and 5 – 80 % reduction in porosity, but increased compactibility (10 – 50 %). Flow decreased (30 – 50 %) only for highly densified excipients such as calcium carbonate and calcium diphosphate. Conclusion: Microcrystalline cellulose and sorbitol are the excipients with the best tableting properties when reprocessing is conducted via wet granulation and direct compression platforms, respectively.spa
dc.format.extent8spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherFaculty of Pharmacy, University of Beninspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleEffect of reprocessing and excipient characteristics on ibuprofen tablet propertiesspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupDiseño y Formulación de Medicamentos Cosméticos y Afinesspa
dc.identifier.doi10.4314/tjpr.v14i7.4-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1596-9827-
oaire.citationtitleTropical Journal of Pharmaceutical Researchspa
oaire.citationstartpage1145spa
oaire.citationendpage1152spa
oaire.citationvolume14spa
oaire.citationissue7spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameUniversidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODIspa
dc.publisher.placeBenin City, Nigeriaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsExcipientes-
dc.subject.decsExcipients-
dc.subject.decsIbuprofeno-
dc.subject.decsIbuprofen-
dc.subject.decsComprimidos-
dc.subject.decsTablets-
oaire.funderidentifier.crossreffunderRoR: 03bp5hc83-
dc.description.researchgroupidCOL0003623spa
oaire.awardnumber2013-2014spa
dc.relation.ispartofjournalabbrevTrop. J. Pharm. Res.spa
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