1. Repositorio Institucional Universidad de Antioquia
  2. Investigaciones
  3. CIQUIFAR (Centro de Investigaciones de la Facultad de Ciencias Farmacéuticas y Alimentarias)
  4. Artículos de Revista en Farmacéutica y Alimentarias
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/39537
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dc.contributor.authorHenao Castañeda, Isabel Cristina-
dc.contributor.authorPreciado Rojo, Lina María-
dc.contributor.authorVillota, Hernán-
dc.contributor.authorMoreno Ceballos, Manuel-
dc.contributor.authorSanta González, Gloria A.-
dc.contributor.authorUribe, Diego-
dc.contributor.authorPedroza Díaz, Johanna-
dc.date.accessioned2024-06-01T20:49:43Z-
dc.date.available2024-06-01T20:49:43Z-
dc.date.issued2021-
dc.identifier.citationVillota, H.; Moreno-Ceballos, M.; Santa-González, G.A.; Uribe, D.; Castañeda, I.C.H.; Preciado, L.M.; Pedroza-Díaz, J. Biological Impact of Phenolic Compounds from Coffee on Colorectal Cancer. Pharmaceuticals 2021, 14, 761. https://doi.org/10.3390/ph14080761spa
dc.identifier.issn1424-8247-
dc.identifier.urihttps://hdl.handle.net/10495/39537-
dc.description.abstractABSTRACT: Colorectal cancer is one of the leading death-related diseases worldwide, usually induced by a multifactorial and complex process, including genetic and epigenetic abnormalities and the impact of diet and lifestyle. In the present study, we evaluated the biological impact of two of the main coffee polyphenols, chlorogenic acid (CGA) and caffeic acid (CA), as well as two polyphenol-rich coffee extracts (green coffee extract and toasted coffee Extract) against SW480 and SW620 colorectal cancer cells. First, the total phenolic content and the antioxidant capability of the extracts were determined. Then, cytotoxicity was evaluated by MTT and SBR. Finally, a wound healing assay was performed to determine the impact on the cell migration process. The results showed a cytotoxic effect of all treatments in a time and dose-dependent manner, which decreased the viability in both cell lines at 24 h and 48 h; likewise, the migration capability of cells decreased with low doses of treatments. These results suggest the potential of coffee to modulate biological mechanisms involved in colorectal cancer development; however, more studies are required to understand the mechanistic insights of these observations.spa
dc.format.extent12 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherMDPIspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleBiological impact of phenolic compounds from coffee on colorectal cancerspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupProductos Naturales Marinosspa
dc.publisher.groupToxinología, Alternativas Terapéuticas y Alimentariasspa
dc.identifier.doi10.3390/ph14080761-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.citationtitlePharmaceuticalsspa
oaire.citationstartpage1spa
oaire.citationendpage12spa
oaire.citationvolume14spa
oaire.citationissue8spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameUniversidad de Antioquiaspa
oaire.fundernameColombia. Ministerio de Ciencia, Tecnología e Innovación - Minicienciasspa
oaire.fundernameInstituto Tecnológico Metropolitanospa
dc.publisher.placeBasilea, Suizaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsCompuestos Fenólicos-
dc.subject.decsPhenolic Compounds-
dc.subject.decsBiología Celular-
dc.subject.decsCell Biology-
dc.subject.decsCafé-
dc.subject.decsCoffee-
dc.subject.decsTecnología Farmacéutica-
dc.subject.decsTechnology, Pharmaceutical-
dc.subject.decsNeoplasias Colorrectales-
dc.subject.decsColorectal Neoplasms-
dc.subject.decsEstilo de Vida-
dc.subject.decsLife Style-
dc.subject.decsÁcido Clorogénico-
dc.subject.decsChlorogenic Acid-
dc.subject.lembProductos naturales-
dc.subject.lembNatural products-
dc.description.researchgroupidCOL0015043spa
dc.description.researchgroupidCOL0014476spa
oaire.awardnumber115080763215 CT 811-2018spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D003585-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D003069-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D013678-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015179-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008019-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D002726-
dc.relation.ispartofjournalabbrevPharmaceuticalsspa
oaire.funderidentifier.rorRoR:03bp5hc83-
oaire.funderidentifier.rorRoR:03fd5ne08-
oaire.funderidentifier.rorRoR:03zb5p722-
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