1. Repositorio Institucional Universidad de Antioquia
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  3. Instituto de Investigaciones Médicas
  4. Artículos de Revista en Ciencias Médicas
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dc.contributor.authorCastaño Monsalve, Diana María-
dc.contributor.authorHeit, Bryan-
dc.contributor.authorKim, Hani-
dc.contributor.authorCosio, Gabriela-
dc.contributor.authorCollins, Richard-
dc.contributor.authorLowell, Clifford A.-
dc.contributor.authorKain, Kevin C.-
dc.contributor.authorTrimble, William S.-
dc.contributor.authorGristein, Sergio-
dc.date.accessioned2024-06-03T11:53:17Z-
dc.date.available2024-06-03T11:53:17Z-
dc.date.issued2013-
dc.identifier.citationHeit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25;24(4):372-83. doi: 10.1016/j.devcel.2013.01.007.spa
dc.identifier.issn1534-5807-
dc.identifier.urihttps://hdl.handle.net/10495/39573-
dc.description.abstractABSTRACT: CD36 is a versatile receptor known to play a central role in the development of atherosclerosis, the pathogenesis of malaria, and the removal of apoptotic cells. Remarkably, the short cytosolically exposed regions of CD36 lack identifiable motifs, which has hampered elucidation of its mode of signaling. Using a combination of phosphoprotein isolation, mass spectrometry, superresolution imaging, and gene silencing, we have determined that the receptor induces ligand internalization through a heteromeric complex consisting of CD36, β1 and/or β2 integrins, and the tetraspanins CD9 and/or CD81. This receptor complex serves to link CD36 to the adaptor FcRγ, which bears an immunoreceptor tyrosine activation motif. By coupling to FcRγ, CD36 is able to engage Src-family kinases and Syk, which in turn drives the internalization of CD36 and its bound ligands.spa
dc.format.extent26 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCell Pressspa
dc.publisherElsevierspa
dc.type.hasversioninfo:eu-repo/semantics/acceptedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleMultimolecular signaling complexes enable Syk-mediated signaling of CD36 internalizationspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo de Inmunología Celular e Inmunogenéticaspa
dc.identifier.doi10.1016/j.devcel.2013.01.007-
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1878-1551-
oaire.citationtitleDevelopmental Cellspa
oaire.citationstartpage1spa
oaire.citationendpage26spa
oaire.citationvolume24spa
oaire.citationissue4spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeCambridge, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsProteínas Adaptadoras Transductoras de Señales-
dc.subject.decsAdaptor Proteins, Signal Transducing-
dc.subject.decsWestern Blotting-
dc.subject.decsBlotting, Western-
dc.subject.decsAntígenos CD36-
dc.subject.decsCD36 Antigens-
dc.subject.decsMetabolismo-
dc.subject.decsMetabolism-
dc.subject.decsEndocitosis-
dc.subject.decsEndocytosis-
dc.subject.decsInmunoprecipitación-
dc.subject.decsImmunoprecipitation-
dc.subject.decsPéptidos y Proteínas de Señalización Intracelular-
dc.subject.decsIntracellular Signaling Peptides and Proteins-
dc.subject.decsMacrófagos Peritoneales-
dc.subject.decsMacrophages, Peritoneal-
dc.subject.decsFosforilación-
dc.subject.decsPhosphorylation-
dc.subject.decsProteínas Tirosina Quinasas-
dc.subject.decsProtein-Tyrosine Kinases-
dc.subject.decsARN Interferente Pequeño-
dc.subject.decsRNA, Small Interfering-
dc.subject.decsReceptores de IgG-
dc.subject.decsReceptors, IgG-
dc.subject.decsTransducción de Señal-
dc.subject.decsSignal Transduction-
dc.subject.decsQuinasa Syk-
dc.subject.decsSyk Kinase-
dc.subject.decsTetraspanina 28-
dc.subject.decsTetraspanin 28-
dc.subject.decsTetraspanina 29-
dc.subject.decsTetraspanin 29-
dc.description.researchgroupidCOL0008639spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D048868-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015153-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D018955-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008660-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004705-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D047468-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D047908-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D017737-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D010766-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D011505-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D034741-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D017452-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015398-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000072377-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D060225-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D060245-
dc.relation.ispartofjournalabbrevDev. Cell.spa
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