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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Bedoya Berrío, Gabriel de Jesús | - |
dc.contributor.author | Ruíz Linares, Andrés | - |
dc.contributor.author | Graff, Mariaelisa | - |
dc.contributor.author | Buchanan, Victoria L. | - |
dc.contributor.author | Justice, Anne E. | - |
dc.contributor.author | Highland, Heather M. | - |
dc.contributor.author | Guo, Xiuqing | - |
dc.contributor.author | Zhu, Wanying | - |
dc.contributor.author | Chen, Hung-Hsin | - |
dc.contributor.author | Young, Kristin L. | - |
dc.contributor.author | Adhikari, Kaustubh | - |
dc.contributor.author | Cole, Shelley A. | - |
dc.contributor.author | Comuzzie, Anthony G. | - |
dc.contributor.author | Voruganti, V Saroja | - |
dc.contributor.author | Rohde, Rebecca | - |
dc.contributor.author | Wang, Yujie | - |
dc.contributor.author | Sofer, Tamar | - |
dc.contributor.author | Ziv, Elad | - |
dc.contributor.author | Grant, Struan F. A. | - |
dc.contributor.author | Fernández Rhodes, Lindsay | - |
dc.contributor.author | Rotter, Jerome I. | - |
dc.contributor.author | Palmer, Nicholette D. | - |
dc.contributor.author | Haiman, Christopher A. | - |
dc.contributor.author | Parra, Esteban J. | - |
dc.contributor.author | Cruz, Miguel | - |
dc.contributor.author | Loos, Ruth J. F. | - |
dc.contributor.author | North, Kari E. | - |
dc.contributor.author | Below, Jennifer E. | - |
dc.contributor.author | Bradfield, Jonathan | - |
dc.contributor.author | Pereira, Alexandre C. | - |
dc.contributor.author | Glover, LáShauntá | - |
dc.contributor.author | Kim, Daeeun | - |
dc.contributor.author | Lilly, Adam G. | - |
dc.contributor.author | Shrestha, Poojan | - |
dc.contributor.author | Thomas, Alvin G. | - |
dc.contributor.author | Zhang, Xinruo | - |
dc.contributor.author | Chen, Minhui | - |
dc.contributor.author | Chiang, Charleston W. K. | - |
dc.contributor.author | Pulit, Sara | - |
dc.contributor.author | Horimoto, Andrea | - |
dc.contributor.author | Krieger, Jose E | - |
dc.contributor.author | Guindo Martínez, Marta | - |
dc.contributor.author | Preuss, Michael | - |
dc.contributor.author | Schumann, Claudia | - |
dc.contributor.author | Smit, Roelof A. J. | - |
dc.contributor.author | Torres Mejía, Gabriela | - |
dc.contributor.author | Acuña Alonzo, Victor | - |
dc.contributor.author | Bortolini, Maria Cátira | - |
dc.contributor.author | Canizales Quinteros, Samuel | - |
dc.contributor.author | Gallo, Carla | - |
dc.contributor.author | González José, Rolando | - |
dc.contributor.author | Poletti, Giovanni | - |
dc.contributor.author | Rothhammer, Francisco | - |
dc.contributor.author | Hakonarson, Hakon | - |
dc.contributor.author | Igo, Robert | - |
dc.contributor.author | Adler, Sharon G. | - |
dc.contributor.author | Iyengar, Sudha K | - |
dc.contributor.author | Nicholas, Susanne B. | - |
dc.contributor.author | Gogarten, Stephanie M. | - |
dc.contributor.author | Isasi, Carmen R. | - |
dc.contributor.author | Papnicolaou, George | - |
dc.contributor.author | Stilp, Adrienne M. | - |
dc.contributor.author | Qi, Qibin | - |
dc.contributor.author | Kho, Minjung | - |
dc.contributor.author | Smith, Jennifer A. | - |
dc.contributor.author | Langefeld, Carl D. | - |
dc.contributor.author | Wagenknecht, Lynne | - |
dc.contributor.author | Mckean Cowdin, Roberta | - |
dc.contributor.author | Gao Xiaoyi, Raymond | - |
dc.contributor.author | Nousome, Darryl | - |
dc.contributor.author | Conti, David V. | - |
dc.contributor.author | Feng, Ye | - |
dc.contributor.author | Allison, Matthew A | - |
dc.contributor.author | Arzumanyan, Zorayr | - |
dc.contributor.author | Chen, Yii-Der Ida | - |
dc.contributor.author | Genter, Pauline M. | - |
dc.contributor.author | Goodarzi, Mark O. | - |
dc.contributor.author | Hai, Yang | - |
dc.contributor.author | Hsueh, Willa | - |
dc.contributor.author | Ipp, Eli | - |
dc.contributor.author | Kandeel, Fouad R. | - |
dc.contributor.author | Lam, Kelvin | - |
dc.contributor.author | Li, Xiaohui | - |
dc.contributor.author | Nadler, Jerry L. | - |
dc.contributor.author | Raffel, Leslie J. | - |
dc.contributor.author | Roll, Kathryn | - |
dc.contributor.author | Sandow, Kevin | - |
dc.contributor.author | Tan, Jingyi | - |
dc.contributor.author | Taylor, Kent D. | - |
dc.contributor.author | Xiang, Anny H. | - |
dc.contributor.author | Yao, Jie | - |
dc.contributor.author | Audirac-Chalifour, Astride | - |
dc.contributor.author | Peralta Romero, José de Jesús | - |
dc.contributor.author | Hartwig, Fernando | - |
dc.contributor.author | Horta, Bernando | - |
dc.contributor.author | Blangero, John | - |
dc.contributor.author | Curran, Joanne E. | - |
dc.contributor.author | Duggirala, Ravindranath | - |
dc.contributor.author | Lehman, Donna E. | - |
dc.contributor.author | Puppala, Sobha | - |
dc.contributor.author | Fejerman, Laura | - |
dc.contributor.author | John, Esther M. | - |
dc.contributor.author | Aguilar Salinas, Carlos | - |
dc.contributor.author | Burtt, Noël P. | - |
dc.contributor.author | Florez, Jose C. | - |
dc.contributor.author | García Ortíz, Humberto | - |
dc.contributor.author | González Villalpando, Clicerio | - |
dc.contributor.author | Mercader, Josep | - |
dc.contributor.author | Orozco, Lorena | - |
dc.contributor.author | Tusié Luna, Teresa | - |
dc.contributor.author | Blanco, Estela | - |
dc.contributor.author | Gahagan, Sheila | - |
dc.contributor.author | Cox, Nancy J. | - |
dc.contributor.author | Hanis, Craig | - |
dc.contributor.author | Butte, Nancy F. | - |
dc.date.accessioned | 2024-08-11T02:01:34Z | - |
dc.date.available | 2024-08-11T02:01:34Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Fernández-Rhodes L, Graff M, Buchanan VL, Justice AE, Highland HM, Guo X, Zhu W, Chen HH, Young KL, Adhikari K, Palmer ND, Below JE, Bradfield J, Pereira AC, Glover L, Kim D, Lilly AG, Shrestha P, Thomas AG, Zhang X, Chen M, Chiang CWK, Pulit S, Horimoto A, Krieger JE, Guindo-Martínez M, Preuss M, Schumann C, Smit RAJ, Torres-Mejía G, Acuña-Alonzo V, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, González-José R, Poletti G, Rothhammer F, Hakonarson H, Igo R, Adler SG, Iyengar SK, Nicholas SB, Gogarten SM, Isasi CR, Papnicolaou G, Stilp AM, Qi Q, Kho M, Smith JA, Langefeld CD, Wagenknecht L, Mckean-Cowdin R, Gao XR, Nousome D, Conti DV, Feng Y, Allison MA, Arzumanyan Z, Buchanan TA, Ida Chen YD, Genter PM, Goodarzi MO, Hai Y, Hsueh W, Ipp E, Kandeel FR, Lam K, Li X, Nadler JL, Raffel LJ, Roll K, Sandow K, Tan J, Taylor KD, Xiang AH, Yao J, Audirac-Chalifour A, de Jesus Peralta Romero J, Hartwig F, Horta B, Blangero J, Curran JE, Duggirala R, Lehman DE, Puppala S, Fejerman L, John EM, Aguilar-Salinas C, Burtt NP, Florez JC, García-Ortíz H, González-Villalpando C, Mercader J, Orozco L, Tusié-Luna T, Blanco E, Gahagan S, Cox NJ, Hanis C, Butte NF, Cole SA, Comuzzie AG, Voruganti VS, Rohde R, Wang Y, Sofer T, Ziv E, Grant SFA, Ruiz-Linares A, Rotter JI, Haiman CA, Parra EJ, Cruz M, Loos RJF, North KE. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium. HGG Adv. 2022 Mar 11;3(2):100099. doi: 10.1016/j.xhgg.2022.100099. Erratum in: HGG Adv. 2022 Oct 11;4(1):100149. doi: 10.1016/j.xhgg.2022.100149. | spa |
dc.identifier.issn | 2666-2477 | - |
dc.identifier.uri | https://hdl.handle.net/10495/41086 | - |
dc.description.abstract | ABSTRACT: Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification. | spa |
dc.format.extent | 21 páginas | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.publisher | Elsevier | spa |
dc.type.hasversion | info:eu-repo/semantics/publishedVersion | spa |
dc.rights | info:eu-repo/semantics/openAccess | spa |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/co/ | * |
dc.title | Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium | spa |
dc.type | info:eu-repo/semantics/article | spa |
dc.publisher.group | Genética Molecular (GENMOL) | spa |
dc.identifier.doi | 10.1016/j.xhgg.2022.100099 | - |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
oaire.citationtitle | HGG dvances | spa |
oaire.citationstartpage | 1 | spa |
oaire.citationendpage | 21 | spa |
oaire.citationvolume | 3 | spa |
oaire.citationissue | 2 | spa |
dc.rights.creativecommons | https://creativecommons.org/licenses/by/4.0/ | spa |
dc.publisher.place | Nueva York, Estados Unidos | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
dc.type.redcol | https://purl.org/redcol/resource_type/ART | spa |
dc.type.local | Artículo de investigación | spa |
dc.subject.decs | Hispánicos o Latinos | - |
dc.subject.decs | Hispanic or Latino | - |
dc.subject.decs | Variación Genética | - |
dc.subject.decs | Genetic Variation | - |
dc.subject.decs | Mapeo Cromosómico | - |
dc.subject.decs | Chromosome Mapping | - |
dc.subject.decs | Obesidad | - |
dc.subject.decs | Obesity | - |
dc.subject.lemb | Antropometría | - |
dc.subject.lemb | Anthropometry | - |
dc.identifier.url | https://www.sciencedirect.com/journal/human-genetics-and-genomics-advances | spa |
dc.description.researchgroupid | COL0006723 | spa |
dc.subject.meshuri | https://id.nlm.nih.gov/mesh/D006630 | - |
dc.subject.meshuri | https://id.nlm.nih.gov/mesh/D014644 | - |
dc.subject.meshuri | https://id.nlm.nih.gov/mesh/D002874 | - |
dc.subject.meshuri | https://id.nlm.nih.gov/mesh/D009765 | - |
dc.relation.ispartofjournalabbrev | HGG Adv. | spa |
Aparece en las colecciones: | Artículos de Revista en Ciencias Exactas y Naturales |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Bedoya_Gabriel_2022_Ancestral_Diversity_Improves.pdf | Artículo de investigación | 1.7 MB | Adobe PDF | Visualizar/Abrir |
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