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dc.contributor.authorBedoya Berrío, Gabriel de Jesús-
dc.contributor.authorRuíz Linares, Andrés-
dc.contributor.authorGraff, Mariaelisa-
dc.contributor.authorBuchanan, Victoria L.-
dc.contributor.authorJustice, Anne E.-
dc.contributor.authorHighland, Heather M.-
dc.contributor.authorGuo, Xiuqing-
dc.contributor.authorZhu, Wanying-
dc.contributor.authorChen, Hung-Hsin-
dc.contributor.authorYoung, Kristin L.-
dc.contributor.authorAdhikari, Kaustubh-
dc.contributor.authorCole, Shelley A.-
dc.contributor.authorComuzzie, Anthony G.-
dc.contributor.authorVoruganti, V Saroja-
dc.contributor.authorRohde, Rebecca-
dc.contributor.authorWang, Yujie-
dc.contributor.authorSofer, Tamar-
dc.contributor.authorZiv, Elad-
dc.contributor.authorGrant, Struan F. A.-
dc.contributor.authorFernández Rhodes, Lindsay-
dc.contributor.authorRotter, Jerome I.-
dc.contributor.authorPalmer, Nicholette D.-
dc.contributor.authorHaiman, Christopher A.-
dc.contributor.authorParra, Esteban J.-
dc.contributor.authorCruz, Miguel-
dc.contributor.authorLoos, Ruth J. F.-
dc.contributor.authorNorth, Kari E.-
dc.contributor.authorBelow, Jennifer E.-
dc.contributor.authorBradfield, Jonathan-
dc.contributor.authorPereira, Alexandre C.-
dc.contributor.authorGlover, LáShauntá-
dc.contributor.authorKim, Daeeun-
dc.contributor.authorLilly, Adam G.-
dc.contributor.authorShrestha, Poojan-
dc.contributor.authorThomas, Alvin G.-
dc.contributor.authorZhang, Xinruo-
dc.contributor.authorChen, Minhui-
dc.contributor.authorChiang, Charleston W. K.-
dc.contributor.authorPulit, Sara-
dc.contributor.authorHorimoto, Andrea-
dc.contributor.authorKrieger, Jose E-
dc.contributor.authorGuindo Martínez, Marta-
dc.contributor.authorPreuss, Michael-
dc.contributor.authorSchumann, Claudia-
dc.contributor.authorSmit, Roelof A. J.-
dc.contributor.authorTorres Mejía, Gabriela-
dc.contributor.authorAcuña Alonzo, Victor-
dc.contributor.authorBortolini, Maria Cátira-
dc.contributor.authorCanizales Quinteros, Samuel-
dc.contributor.authorGallo, Carla-
dc.contributor.authorGonzález José, Rolando-
dc.contributor.authorPoletti, Giovanni-
dc.contributor.authorRothhammer, Francisco-
dc.contributor.authorHakonarson, Hakon-
dc.contributor.authorIgo, Robert-
dc.contributor.authorAdler, Sharon G.-
dc.contributor.authorIyengar, Sudha K-
dc.contributor.authorNicholas, Susanne B.-
dc.contributor.authorGogarten, Stephanie M.-
dc.contributor.authorIsasi, Carmen R.-
dc.contributor.authorPapnicolaou, George-
dc.contributor.authorStilp, Adrienne M.-
dc.contributor.authorQi, Qibin-
dc.contributor.authorKho, Minjung-
dc.contributor.authorSmith, Jennifer A.-
dc.contributor.authorLangefeld, Carl D.-
dc.contributor.authorWagenknecht, Lynne-
dc.contributor.authorMckean Cowdin, Roberta-
dc.contributor.authorGao Xiaoyi, Raymond-
dc.contributor.authorNousome, Darryl-
dc.contributor.authorConti, David V.-
dc.contributor.authorFeng, Ye-
dc.contributor.authorAllison, Matthew A-
dc.contributor.authorArzumanyan, Zorayr-
dc.contributor.authorChen, Yii-Der Ida-
dc.contributor.authorGenter, Pauline M.-
dc.contributor.authorGoodarzi, Mark O.-
dc.contributor.authorHai, Yang-
dc.contributor.authorHsueh, Willa-
dc.contributor.authorIpp, Eli-
dc.contributor.authorKandeel, Fouad R.-
dc.contributor.authorLam, Kelvin-
dc.contributor.authorLi, Xiaohui-
dc.contributor.authorNadler, Jerry L.-
dc.contributor.authorRaffel, Leslie J.-
dc.contributor.authorRoll, Kathryn-
dc.contributor.authorSandow, Kevin-
dc.contributor.authorTan, Jingyi-
dc.contributor.authorTaylor, Kent D.-
dc.contributor.authorXiang, Anny H.-
dc.contributor.authorYao, Jie-
dc.contributor.authorAudirac-Chalifour, Astride-
dc.contributor.authorPeralta Romero, José de Jesús-
dc.contributor.authorHartwig, Fernando-
dc.contributor.authorHorta, Bernando-
dc.contributor.authorBlangero, John-
dc.contributor.authorCurran, Joanne E.-
dc.contributor.authorDuggirala, Ravindranath-
dc.contributor.authorLehman, Donna E.-
dc.contributor.authorPuppala, Sobha-
dc.contributor.authorFejerman, Laura-
dc.contributor.authorJohn, Esther M.-
dc.contributor.authorAguilar Salinas, Carlos-
dc.contributor.authorBurtt, Noël P.-
dc.contributor.authorFlorez, Jose C.-
dc.contributor.authorGarcía Ortíz, Humberto-
dc.contributor.authorGonzález Villalpando, Clicerio-
dc.contributor.authorMercader, Josep-
dc.contributor.authorOrozco, Lorena-
dc.contributor.authorTusié Luna, Teresa-
dc.contributor.authorBlanco, Estela-
dc.contributor.authorGahagan, Sheila-
dc.contributor.authorCox, Nancy J.-
dc.contributor.authorHanis, Craig-
dc.contributor.authorButte, Nancy F.-
dc.date.accessioned2024-08-11T02:01:34Z-
dc.date.available2024-08-11T02:01:34Z-
dc.date.issued2022-
dc.identifier.citationFernández-Rhodes L, Graff M, Buchanan VL, Justice AE, Highland HM, Guo X, Zhu W, Chen HH, Young KL, Adhikari K, Palmer ND, Below JE, Bradfield J, Pereira AC, Glover L, Kim D, Lilly AG, Shrestha P, Thomas AG, Zhang X, Chen M, Chiang CWK, Pulit S, Horimoto A, Krieger JE, Guindo-Martínez M, Preuss M, Schumann C, Smit RAJ, Torres-Mejía G, Acuña-Alonzo V, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, González-José R, Poletti G, Rothhammer F, Hakonarson H, Igo R, Adler SG, Iyengar SK, Nicholas SB, Gogarten SM, Isasi CR, Papnicolaou G, Stilp AM, Qi Q, Kho M, Smith JA, Langefeld CD, Wagenknecht L, Mckean-Cowdin R, Gao XR, Nousome D, Conti DV, Feng Y, Allison MA, Arzumanyan Z, Buchanan TA, Ida Chen YD, Genter PM, Goodarzi MO, Hai Y, Hsueh W, Ipp E, Kandeel FR, Lam K, Li X, Nadler JL, Raffel LJ, Roll K, Sandow K, Tan J, Taylor KD, Xiang AH, Yao J, Audirac-Chalifour A, de Jesus Peralta Romero J, Hartwig F, Horta B, Blangero J, Curran JE, Duggirala R, Lehman DE, Puppala S, Fejerman L, John EM, Aguilar-Salinas C, Burtt NP, Florez JC, García-Ortíz H, González-Villalpando C, Mercader J, Orozco L, Tusié-Luna T, Blanco E, Gahagan S, Cox NJ, Hanis C, Butte NF, Cole SA, Comuzzie AG, Voruganti VS, Rohde R, Wang Y, Sofer T, Ziv E, Grant SFA, Ruiz-Linares A, Rotter JI, Haiman CA, Parra EJ, Cruz M, Loos RJF, North KE. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium. HGG Adv. 2022 Mar 11;3(2):100099. doi: 10.1016/j.xhgg.2022.100099. Erratum in: HGG Adv. 2022 Oct 11;4(1):100149. doi: 10.1016/j.xhgg.2022.100149.spa
dc.identifier.issn2666-2477-
dc.identifier.urihttps://hdl.handle.net/10495/41086-
dc.description.abstractABSTRACT: Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imputed genetic data in a sample of Hispanic/Latino adults to identify and fine-map genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (stage 1, n = 59,771) and generalized our findings in 9 additional studies (stage 2, n = 10,538). We conducted a trans-ancestral GWAS with summary statistics from HISLA stage 1 and existing consortia of European and African ancestries. In our HISLA stage 1 + 2 analyses, we discovered one BMI locus, as well as two BMI signals and another height signal each within established anthropometric loci. In our trans-ancestral meta-analysis, we discovered three BMI loci, one height locus, and one WHRadjBMI locus. We also identified 3 secondary signals for BMI, 28 for height, and 2 for WHRadjBMI in established loci. We show that 336 known BMI, 1,177 known height, and 143 known WHRadjBMI (combined) SNPs demonstrated suggestive transferability (nominal significance and effect estimate directional consistency) in Hispanic/Latino adults. Of these, 36 BMI, 124 height, and 11 WHRadjBMI SNPs were significant after trait-specific Bonferroni correction. Trans-ancestral meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our findings demonstrate that future studies may also benefit from leveraging diverse ancestries and differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.spa
dc.format.extent21 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherElsevierspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleAncestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortiumspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.1016/j.xhgg.2022.100099-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.citationtitleHGG dvancesspa
oaire.citationstartpage1spa
oaire.citationendpage21spa
oaire.citationvolume3spa
oaire.citationissue2spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeNueva York, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsHispánicos o Latinos-
dc.subject.decsHispanic or Latino-
dc.subject.decsVariación Genética-
dc.subject.decsGenetic Variation-
dc.subject.decsMapeo Cromosómico-
dc.subject.decsChromosome Mapping-
dc.subject.decsObesidad-
dc.subject.decsObesity-
dc.subject.lembAntropometría-
dc.subject.lembAnthropometry-
dc.identifier.urlhttps://www.sciencedirect.com/journal/human-genetics-and-genomics-advancesspa
dc.description.researchgroupidCOL0006723spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D006630-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D014644-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D002874-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D009765-
dc.relation.ispartofjournalabbrevHGG Adv.spa
Aparece en las colecciones: Artículos de Revista en Ciencias Exactas y Naturales

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