1. Repositorio Institucional Universidad de Antioquia
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  3. CIEN (Centro de Investigaciones en Ciencias Exactas y Naturales)
  4. Artículos de Revista en Ciencias Exactas y Naturales
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/41091
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dc.contributor.authorBedoya Berrío, Gabriel de Jesús-
dc.contributor.authorRuíz Linares, Andrés-
dc.contributor.authorRachmin, Inbal-
dc.contributor.authorAdhikari, Kaustubh-
dc.contributor.authorPardo, Luba M.-
dc.contributor.authorLee, Ju Hee-
dc.contributor.authorMcConnell, Alicia M.-
dc.contributor.authorKato, Shinichiro-
dc.contributor.authorFan, Shaohua-
dc.contributor.authorKawakami, Akinori-
dc.contributor.authorSuita, Yusuke-
dc.contributor.authorWakamatsu, Kazumasa-
dc.contributor.authorIgras, Vivien-
dc.contributor.authorZhang, Jianming-
dc.contributor.authorNavarro, Paula P-
dc.contributor.authorMakhlouta Lugo, Camila-
dc.contributor.authorR Noonan, Haley-
dc.contributor.authorChristie, Kathleen A.-
dc.contributor.authorItin, Kaspar-
dc.contributor.authorMujahid, Nisma-
dc.contributor.authorLo, Jennifer V.-
dc.contributor.authorHyun Won, Chong-
dc.contributor.authorEvans, Conor L.-
dc.contributor.authorYu Weng, Qing-
dc.contributor.authorWang, Hequn-
dc.contributor.authorOsseiran, Sam-
dc.contributor.authorLovas, Alyssa-
dc.contributor.authorNémeth, István-
dc.contributor.authorCozzio, Antonio-
dc.contributor.authorNavarini, Alexander A.-
dc.contributor.authorHsiao, Jennifer J.-
dc.contributor.authorNguyen, Nhu-
dc.contributor.authorKemény, Lajos V.-
dc.contributor.authorIliopoulos, Othon-
dc.contributor.authorBerking, Carola-
dc.contributor.authorRuzicka, Thomas-
dc.contributor.authorGonzalez-José, Rolando-
dc.contributor.authorBortolini, Maria Cátira-
dc.contributor.authorCanizales Quinteros, Samuel-
dc.contributor.authorAcuna Alonso, Víctor-
dc.contributor.authorGallo, Carla-
dc.contributor.authorPoletti, Giovanni-
dc.contributor.authorRothhammer, Francisco-
dc.contributor.authorIto, Shosuke-
dc.contributor.authorSchiaffino, Maria Vittoria-
dc.contributor.authorChao, Luke H.-
dc.contributor.authorKleinstiver, Benjamin P.-
dc.contributor.authorTishkoff, Sarah-
dc.contributor.authorZon, Leonard I.-
dc.contributor.authorNijsten, Tamar-
dc.contributor.authorAllouche, Jennifer-
dc.contributor.authorFisher, David E-
dc.contributor.authorRoider, Elisabeth-
dc.date.accessioned2024-08-11T16:25:46Z-
dc.date.available2024-08-11T16:25:46Z-
dc.date.issued2021-
dc.identifier.citationAllouche J, Rachmin I, Adhikari K, Pardo LM, Lee JH, McConnell AM, Kato S, Fan S, Kawakami A, Suita Y, Wakamatsu K, Igras V, Zhang J, Navarro PP, Lugo CM, Noonan HR, Christie KA, Itin K, Mujahid N, Lo JA, Won CH, Evans CL, Weng QY, Wang H, Osseiran S, Lovas A, Németh I, Cozzio A, Navarini AA, Hsiao JJ, Nguyen N, Kemény LV, Iliopoulos O, Berking C, Ruzicka T, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Acuna-Alonso V, Gallo C, Poletti G, Bedoya G, Rothhammer F, Ito S, Schiaffino MV, Chao LH, Kleinstiver BP, Tishkoff S, Zon LI, Nijsten T, Ruiz-Linares A, Fisher DE, Roider E. NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism. Cell. 2021 Aug 5;184(16):4268-4283.e20. doi: 10.1016/j.cell.2021.06.022. Epub 2021 Jul 6.spa
dc.identifier.issn0092-8674-
dc.identifier.urihttps://hdl.handle.net/10495/41091-
dc.description.abstractABSTRACT: Ultraviolet (UV) light and incompletely understood genetic and epigenetic variations determine skin color. Here we describe an UV- and microphthalmia-associated transcription factor (MITF)-independent mechanism of skin pigmentation. Targeting the mitochondrial redox-regulating enzyme nicotinamide nucleotide transhydrogenase (NNT) resulted in cellular redox changes that affect tyrosinase degradation. These changes regulate melanosome maturation and, consequently, eumelanin levels and pigmentation. Topical application of small-molecule inhibitors yielded skin darkening in human skin, and mice with decreased NNT function displayed increased pigmentation. Additionally, genetic modification of NNT in zebrafish alters melanocytic pigmentation. Analysis of four diverse human cohorts revealed significant associations of skin color, tanning, and sun protection use with various single-nucleotide polymorphisms within NNT. NNT levels were independent of UVB irradiation and redox modulation. Individuals with postinflammatory hyperpigmentation or lentigines displayed decreased skin NNT levels, suggesting an NNT-driven, redox-dependent pigmentation mechanism that can be targeted with NNT-modifying topical drugs for medical and cosmetic purposes.spa
dc.format.extent16 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherCell Pressspa
dc.publisherElsevierspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.5/co/*
dc.titleNNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanismspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.1016/j.cell.2021.06.022-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1097-4172-
oaire.citationtitleCellspa
oaire.citationstartpage4268spa
oaire.citationendpage4283spa
oaire.citationvolume184spa
oaire.citationissue16spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeCambridge, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsCell Line-
dc.subject.decsLínea Celular-
dc.subject.decsCohort Studies-
dc.subject.decsEstudios de Cohortes-
dc.subject.decsCyclic AMP-
dc.subject.decsAMP Cíclico-
dc.subject.decsDNA Damage-
dc.subject.decsDaño del ADN-
dc.subject.decsEnzyme Inhibitors-
dc.subject.decsInhibidores Enzimáticos-
dc.subject.decsGenetic Predisposition to Disease-
dc.subject.decsPredisposición Genética a la Enfermedad-
dc.subject.decsMelanocytes-
dc.subject.decsMelanocitos-
dc.subject.decsMelanosomes-
dc.subject.decsMelanosomas-
dc.subject.decsMice, Inbred C57BL-
dc.subject.decsRatones Endogámicos C57BL-
dc.subject.decsMicrophthalmia-Associated Transcription Factor-
dc.subject.decsFactor de Transcripción Asociado a Microftalmía-
dc.subject.decsMitochondria-
dc.subject.decsMitocondria-
dc.subject.decsMonophenol Monooxygenase-
dc.subject.decsMonofenol Monooxigenasa-
dc.subject.decsNADP Transhydrogenases-
dc.subject.decsNADP Transhidrogenasas-
dc.subject.decsOxidation-Reduction-
dc.subject.decsOxidación-Reducción-
dc.subject.decsPolymorphism, Single Nucleotide-
dc.subject.decsPolimorfismo de Nucleótido Simple-
dc.subject.decsProteasome Endopeptidase Complex-
dc.subject.decsComplejo de la Endopetidasa Proteasomal-
dc.subject.decsProteolysis-
dc.subject.decsProteólisis-
dc.subject.decsRNA, Messenger-
dc.subject.decsARN Mensajero-
dc.subject.decsSkin Pigmentation-
dc.subject.decsPigmentación de la Piel-
dc.subject.decsUbiquitin-
dc.subject.decsUltraviolet Rays-
dc.subject.decsRayos Ultravioletas-
dc.subject.decsUbiquitina-
dc.description.researchgroupidCOL0006723spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D002460-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015331-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000242-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004249-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004791-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020022-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008544-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020460-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008810-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D051739-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008928-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D014442-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D009250-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D010084-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020641-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D046988-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D059748-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012333-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012880-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D025801-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D014466-
dc.relation.ispartofjournalabbrevCellspa
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