1. Repositorio Institucional Universidad de Antioquia
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  3. CIEN (Centro de Investigaciones en Ciencias Exactas y Naturales)
  4. Artículos de Revista en Ciencias Exactas y Naturales
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/41106
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dc.contributor.authorBedoya Berrío, Gabriel de Jesús-
dc.contributor.authorRuíz Linares, Andrés-
dc.contributor.authorMarcelain, Katherine-
dc.contributor.authorBarahona Ponce, Carol-
dc.contributor.authorBaez Benavides, Pablo F.-
dc.contributor.authorMüller, Bettina-
dc.contributor.authorde Toro, Gonzalo-
dc.contributor.authorRetamales, Javier-
dc.contributor.authorBarajas, Olga-
dc.contributor.authorAhumada, Monica-
dc.contributor.authorMorales, Erik-
dc.contributor.authorRojas, Armando-
dc.contributor.authorSanhueza, Verónica-
dc.contributor.authorLoader, Denisse-
dc.contributor.authorRivera, María Teresa-
dc.contributor.authorGutiérrez, Lorena-
dc.contributor.authorBernal, Giuliano-
dc.contributor.authorOrtega, Alejandro-
dc.contributor.authorMontalvo, Domingo-
dc.contributor.authorPortiño, Sergio-
dc.contributor.authorBertrán, Maria Enriqueta-
dc.contributor.authorGabler, Fernando-
dc.contributor.authorSpencer, Loreto-
dc.contributor.authorOlloquequi, Jordi-
dc.contributor.authorGonzález Silos, Rosa-
dc.contributor.authorFischer, Christine-
dc.contributor.authorScherer, Dominique-
dc.contributor.authorJenab, Mazda-
dc.contributor.authorAleksandrova, Krasimira-
dc.contributor.authorKatzke, Verena-
dc.contributor.authorWeiderpass, Elisabete-
dc.contributor.authorMoradi, Tahereh-
dc.contributor.authorFischer, Krista-
dc.contributor.authorBossers, Willem-
dc.contributor.authorBrenner, Hermann-
dc.contributor.authorHveem, Kristian-
dc.contributor.authorEklund, Niina-
dc.contributor.authorVölker, Uwe-
dc.contributor.authorWaldenberger, Melanie-
dc.contributor.authorFuentes Guajardo, Macarena-
dc.contributor.authorGonzález José, Rolando-
dc.contributor.authorBortolini, Maria C.-
dc.contributor.authorCanizales, Samuel-
dc.contributor.authorGallo, Carla-
dc.contributor.authorBoekstegers, Felix-
dc.contributor.authorRothhammer, Francisco-
dc.contributor.authorBermejo, Justo Lorenzo-
dc.date.accessioned2024-08-12T02:40:23Z-
dc.date.available2024-08-12T02:40:23Z-
dc.date.issued2020-
dc.identifier.citationBoekstegers F, Marcelain K, Barahona Ponce C, Baez Benavides PF, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, González Silos R, Fischer C, Scherer D, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales S, Gallo C, Ruiz Linares A, Rothhammer F, Lorenzo Bermejo J. ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans. Cancer Epidemiol. 2020 Apr;65:101643. doi: 10.1016/j.canep.2019.101643.spa
dc.identifier.issn1877-7821-
dc.identifier.urihttps://hdl.handle.net/10495/41106-
dc.description.abstractABSTRACT: Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.spa
dc.format.extent5 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherElsevierspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileansspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.1016/j.canep.2019.101643-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1877-783X-
oaire.citationtitleCancer Epidemiologyspa
oaire.citationstartpage1spa
oaire.citationendpage5spa
oaire.citationvolume65spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameFederal Ministry of Education and Researchspa
oaire.fundernameEuropean Unionspa
oaire.fundernameHeidelberg Universityspa
oaire.fundernameUniversity of Chilespa
dc.publisher.placeÁmsterdam, Países Bajosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsATP Binding Cassette Transporter, Subfamily B-
dc.subject.decsSubfamilia B de Transportador de Casetes de Unión a ATP-
dc.subject.decsCase-Control Studies-
dc.subject.decsEstudios de Casos y Controles-
dc.subject.decsGallbladder Neoplasms-
dc.subject.decsNeoplasias de la Vesícula Biliar-
dc.subject.decsGenetic Association Studies-
dc.subject.decsEstudios de Asociación Genética-
dc.subject.decsGenetic Predisposition to Disease-
dc.subject.decsPredisposición Genética a la Enfermedad-
dc.subject.decsPolymorphism, Single Nucleotide-
dc.subject.decsPolimorfismo de Nucleótido Simple-
dc.subject.decsProspective Studies-
dc.subject.decsEstudios Prospectivos-
dc.subject.decsRetrospective Studies-
dc.subject.decsEstudios Retrospectivos-
dc.subject.decsIndians, South American-
dc.subject.decsIndígenas Sudamericanos-
dc.subject.decsPoblación Blanca-
dc.subject.decsWhite People-
oaire.awardtitleIdentificación de biomarcadores para la predicción del riesgo de cáncer de vesícula biliar - Hacia la prevención personalizada de una enfermedad huérfanaspa
dc.description.researchgroupidCOL0006723spa
oaire.awardnumberBMBF, grant 01DN15021spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D018435-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D016022-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005706-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D056726-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020022-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020641-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D011446-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012189-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D007199-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D044465-
dc.relation.ispartofjournalabbrevCancer Epidemiol.spa
oaire.funderidentifier.rorRoR:04pz7b180-
oaire.funderidentifier.rorRoR:019w4f821-
oaire.funderidentifier.rorRoR:04rcqnp59-
oaire.funderidentifier.rorRoR:047gc3g35-
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