1. Repositorio Institucional Universidad de Antioquia
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  3. CIEN (Centro de Investigaciones en Ciencias Exactas y Naturales)
  4. Artículos de Revista en Ciencias Exactas y Naturales
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/41126
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dc.contributor.authorBedoya Berrío, Gabriel de Jesús-
dc.contributor.authorArias Pérez, William Hernán-
dc.contributor.authorJaramillo Alzate, Claudia Milena-
dc.contributor.authorRuíz Linares, Andrés-
dc.contributor.authorMendoza Revilla, Javier-
dc.contributor.authorSohail, Anood-
dc.contributor.authorFuentes Guajardo, Macarena-
dc.contributor.authorLampert, Jodie-
dc.contributor.authorChacón Duque, Juan Camilo-
dc.contributor.authorHurtado, Malena-
dc.contributor.authorVillegas, Valeria-
dc.contributor.authorGranja, Vanessa-
dc.contributor.authorAcuña Alonzo, Víctor-
dc.contributor.authorBarquera Lozano, Rodrigo-
dc.contributor.authorEverardo, Paola-
dc.contributor.authorGómez Valdés, Jorge-
dc.contributor.authorVillamil Ramírez, Hugo-
dc.contributor.authorSilva de Cerqueira, Caio C.-
dc.contributor.authorHunemeier, Tábita-
dc.contributor.authorRamallo, Virginia-
dc.contributor.authorSchuler Faccini, Lavinia-
dc.contributor.authorSalzano, Francisco M.-
dc.contributor.authorGonzález José, Rolando-
dc.contributor.authorBortolini, Maria Cátira-
dc.contributor.authorCanizales Quinteros, Samuel-
dc.contributor.authorGallo, Carla-
dc.contributor.authorPoletti, Giovanni-
dc.contributor.authorRothhammer, Francisco-
dc.contributor.authorTobin, Desmond J.-
dc.contributor.authorFumagalli, Matteo-
dc.contributor.authorBalding, David-
dc.contributor.authorAdhikari, Kaustubh-
dc.date.accessioned2024-08-13T00:40:40Z-
dc.date.available2024-08-13T00:40:40Z-
dc.date.issued2019-
dc.identifier.citationAdhikari K, Mendoza-Revilla J, Sohail A, Fuentes-Guajardo M, Lampert J, Chacón-Duque JC, Hurtado M, Villegas V, Granja V, Acuña-Alonzo V, Jaramillo C, Arias W, Lozano RB, Everardo P, Gómez-Valdés J, Villamil-Ramírez H, Silva de Cerqueira CC, Hunemeier T, Ramallo V, Schuler-Faccini L, Salzano FM, Gonzalez-José R, Bortolini MC, Canizales-Quinteros S, Gallo C, Poletti G, Bedoya G, Rothhammer F, Tobin DJ, Fumagalli M, Balding D, Ruiz-Linares A. A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia. Nat Commun. 2019 Jan 21;10(1):358. doi: 10.1038/s41467-018-08147-0.spa
dc.identifier.urihttps://hdl.handle.net/10495/41126-
dc.description.abstractABSTRACT: We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. We found eighteen signals of association at twelve genomic regions. These include one novel locus for skin pigmentation (in 10q26) and three novel loci for eye pigmentation (in 1q32, 20q13 and 22q12). We demonstrate the presence of multiple independent signals of association in the 11q14 and 15q13 regions (comprising the GRM5/TYR and HERC2/OCA2 genes, respectively) and several epistatic interactions among independently associated alleles. Strongest association with skin pigmentation at 19p13 was observed for an Y182H missense variant (common only in East Asians and Native Americans) in MFSD12, a gene recently associated with skin pigmentation in Africans. We show that the frequency of the derived allele at Y182H is significantly correlated with lower solar radiation intensity in East Asia and infer that MFSD12 was under selection in East Asians, probably after their split from Europeans.spa
dc.format.extent16 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature Researchspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.titleA GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasiaspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.1038/s41467-018-08147-0-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2041-1723-
oaire.citationtitleNature Communicationsspa
oaire.citationstartpage1spa
oaire.citationendpage16spa
oaire.citationvolume10spa
oaire.citationissue1spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeLondres, Inglaterraspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsBiological Evolution-
dc.subject.decsEvolución Biológica-
dc.subject.decsEpistasis, Genetic-
dc.subject.decsEpistasis Genética-
dc.subject.decsGene Expression-
dc.subject.decsExpresión Génica-
dc.subject.decsGene Frequency-
dc.subject.decsFrecuencia de los Genes-
dc.subject.decsGenetics, Population-
dc.subject.decsGenética de Población-
dc.subject.decsGenome, Human-
dc.subject.decsGenoma Humano-
dc.subject.decsGenome-Wide Association Study-
dc.subject.decsEstudio de Asociación del Genoma Completo-
dc.subject.decsGuanine Nucleotide Exchange Factors-
dc.subject.decsFactores de Intercambio de Guanina Nucleótido-
dc.subject.decsMembrane Proteins-
dc.subject.decsProteínas de la Membrana-
dc.subject.decsMembrane Transport Proteins-
dc.subject.decsProteínas de Transporte de Membrana-
dc.subject.decsPolymorphism, Single Nucleotide-
dc.subject.decsPolimorfismo de Nucleótido Simple-
dc.subject.decsQuantitative Trait Loci-
dc.subject.decsSitios de Carácter Cuantitativo-
dc.subject.decsReceptor, Metabotropic Glutamate 5-
dc.subject.decsReceptor del Glutamato Metabotropico 5-
dc.subject.decsSkin Pigmentation-
dc.subject.decsPigmentación de la Piel-
dc.subject.decsUbiquitin-Protein Ligases-
dc.subject.decsUbiquitina-Proteína Ligasas-
dc.description.researchgroupidCOL0006723spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005075-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004843-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015870-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005787-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005828-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015894-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D055106-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020662-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008565-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D026901-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D020641-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D040641-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D064529-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012880-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D044767-
dc.relation.ispartofjournalabbrevNat. Commun.spa
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