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dc.contributor.authorCarbal Reyes, Luisa Fernanda-
dc.contributor.authorTobón Castaño, Alberto-
dc.contributor.authorLondoño Rentería, Berlín Luxelly-
dc.contributor.authorMontiel Ramos, Jehidys-
dc.contributor.authorFisher, Michael L.-
dc.contributor.authorVásquez, Gissella M.-
dc.date.accessioned2024-09-12T18:36:12Z-
dc.date.available2024-09-12T18:36:12Z-
dc.date.issued2020-
dc.identifier.citationMontiel J, Carbal LF, Tobón-Castaño A, Vásquez GM, Fisher ML, Londono-Rentería B. IgG antibody response against Anopheles salivary gland proteins in asymptomatic Plasmodium infections in Narino, Colombia. Malar J. 2020 Jan 23;19(1):42. doi: 10.1186/s12936-020-3128-9.spa
dc.identifier.issn1475-2876-
dc.identifier.urihttps://hdl.handle.net/10495/42069-
dc.description.abstractABSTRACT: Background: The humoral immune response against Anopheles salivary glands proteins in the vertebrate host can reflect the intensity of exposure to Anopheles bites and the risk of Plasmodium infection. In Colombia, the identification of exposure biomarkers is necessary due to the several Anopheles species circulating. The purpose of this study was to evaluate risk of malaria infection by measuring antibody responses against salivary glands extracts from Anopheles (Nyssorhynchus) albimanus and Anopheles (Nys.) darlingi and also against the gSG6-P1 peptide of Anopheles gambiae in people residing in a malaria endemic area in the Colombian Pacific coast. Methods: Dried blood spots samples were eluted to measure the IgG antibodies against salivary gland extracts of An. albimanus strains STECLA (STE) and Cartagena (CTG) and An. darlingi and the gSG6-P1 peptide by ELISA in uninfected people and microscopic and submicroscopic Plasmodium carriers from the Colombia Pacific Coast. A multiple linear mixed regression model, Spearman correlation, and Mann-Whitney U-test were used to analyse IgG data. Results: Significant differences in specific IgG levels were detected between infected and uninfected groups for salivary glands extracts from An. albimanus and for gSG6-P1, also IgG response to CTG and gSG6-P1 peptide were positively associated with the IgG response to Plasmodium falciparum in the mixed model. Conclusion: The CTG and STE An. albimanus salivary glands extracts are a potential source of new Anopheles salivary biomarkers to identify exposure to the main malaria vector and to calculate risk of disease in the Colombian Pacific coast. Also, the gSG6-P1 peptide has the potential to quantify human exposure to the subgenus Anopheles vectors in the same area. Keywords: An. (Nys.) albimanus; An. (Nys.) darlingi; Antibodies; Asymptomatic malaria; Bite exposure.spa
dc.format.extent13 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBMC (BioMed Central)spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleIgG antibody response against Anopheles salivary gland proteins in asymptomatic Plasmodium infections in Narino, Colombiaspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo Malariaspa
dc.identifier.doi10.1186/s12936-020-3128-9-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.citationtitleMalaria Journalspa
oaire.citationstartpage1spa
oaire.citationendpage13spa
oaire.citationvolume19spa
oaire.citationissue1spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameColombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasspa
dc.publisher.placeLondres, Inglaterraspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsAnopheles-
dc.subject.decsMalaria-
dc.subject.decsColombia - epidemiología-
dc.subject.decsColombia - epidemiology-
dc.subject.decsEnsayo de Inmunoadsorción Enzimática-
dc.subject.decsEnzyme-Linked Immunosorbent Assay-
dc.subject.decsInmunoglobulina G-
dc.subject.decsImmunoglobulin G-
dc.subject.decsMosquitos Vectores-
dc.subject.decsMosquito Vectors-
dc.subject.decsProteínas y Péptidos Salivales-
dc.subject.decsSalivary Proteins and Peptides-
dc.description.researchgroupidCOL0007524spa
oaire.awardnumberMinCiencias RC-766-2016, Code 111574455032spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000852-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008288-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004797-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D007074-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000072138-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012471-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D003105-
dc.relation.ispartofjournalabbrevMalar. J.spa
oaire.funderidentifier.rorRoR:03fd5ne08-
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