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https://hdl.handle.net/10495/43125| Título : | Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome |
| Autor : | Franco Restrepo, José Luis Yeganeh, Mehdi Henneke, Philipp Rezaei, Nima Ehl, Stephan Thiel, Doerte Matamoros, Nuria Pietrogrande, Cristina Espanol, Teresa Litzman, Jiri Sanal, Ozden Kilic, Sara S. Breborowicz, Anna Plebani, Alessandro Renner, Ellen Rothenfusser, Simon Hawn, Thomas R. Woellner, Cristina Grimbacher, Bodo |
| metadata.dc.subject.*: | Cohort Studies Estudios de Cohortes Interleukin-8 Interleucina-8 Job Syndrome Síndrome de Job Leukocytes, Mononuclear Leucocitos Mononucleares Lipopolysaccharides Lipopolisacáridos Signal Transduction Transducción de Señal Statistics, Nonparametric Estadísticas no Paramétricas Toll-Like Receptor 2 Toll-Like Receptor 4 Receptor Toll-Like 4 Receptor Toll-Like 2 Tumor Necrosis Factor-alpha Factor de Necrosis Tumoral alfa https://id.nlm.nih.gov/mesh/D015331 https://id.nlm.nih.gov/mesh/D016209 https://id.nlm.nih.gov/mesh/D007589 https://id.nlm.nih.gov/mesh/D007963 https://id.nlm.nih.gov/mesh/D008070 https://id.nlm.nih.gov/mesh/D015398 https://id.nlm.nih.gov/mesh/D018709 https://id.nlm.nih.gov/mesh/D051195 https://id.nlm.nih.gov/mesh/D051197 https://id.nlm.nih.gov/mesh/D014409 |
| Fecha de publicación : | 2008 |
| Editorial : | Karger Publishers |
| Citación : | Yeganeh M, Henneke P, Rezaei N, Ehl S, Thiel D, Matamoros N, Pietrogrande C, Espanol T, Litzman J, Franco JL, Sanal O, Kilic SS, Breborowicz A, Plebani A, Renner E, Rothenfusser S, Hawn TR, Woellner C, Grimbacher B. Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome. Int Arch Allergy Immunol. 2008;146(3):190-4. doi: 10.1159/000115886. Epub 2008 Feb 11. PMID: 18268386. |
| Resumen : | ABSTRACT: Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. |
| metadata.dc.identifier.eissn: | 1423-0097 |
| ISSN : | 1018-2438 |
| metadata.dc.identifier.doi: | 10.1159/000115886 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| FrancoJose_2008_Toll-like_Receptor_Stimulation.pdf | Artículo de investigación | 139.47 kB | Adobe PDF | Visualizar/Abrir |
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