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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Higuita David, Edwin Andrés | - |
dc.contributor.author | Jaimes Barragán, Fabián Alberto | - |
dc.contributor.author | Rugeles López, María Teresa | - |
dc.contributor.author | Montoya Guarín, Carlos Julio | - |
dc.date.accessioned | 2017-09-27T15:39:29Z | - |
dc.date.available | 2017-09-27T15:39:29Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Higuita EA, Jaimes FA, Rugeles MT, Montoya CJ. In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4. AIDS Res Ther. 2013;10(10): 1-12. doi: 10.1186/1742-6405-10-10. | spa |
dc.identifier.issn | 1742-6405 | - |
dc.identifier.uri | http://hdl.handle.net/10495/8361 | - |
dc.description.abstract | ABSTARCT: During the HIV-1 replication cycle, several molecules including chemokine receptors and cholesterol are crucial, and are therefore potential targets for therapeutic intervention. Indeed statins, compounds that inhibit cellular synthesis of cholesterol and have anti-inflammatory and immunomodulatory properties were shown to inhibit HIV-1 infection by R5 tropic strains but not by X4 strains in vitro, mainly by altering the chemokine receptor/ligands axes. Therefore, the objective of this study was to characterize in vivo, the capacity of statins to modulate in HIV seronegative and chronically HIV-1-infected adults the expression of CCR5 and CXCR4, of their ligands and the tropism of circulating HIV-1 strains | spa |
dc.format.extent | 11 | spa |
dc.format.mimetype | application/pdf | spa |
dc.language.iso | eng | spa |
dc.publisher | BioMed Central | spa |
dc.type.hasversion | info:eu-repo/semantics/publishedVersion | spa |
dc.rights | Atribución 2.5 | * |
dc.rights | info:eu-repo/semantics/openAccess | spa |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/co/ | * |
dc.subject | HIV infection | - |
dc.subject | Statins | - |
dc.subject | CCR5 | - |
dc.subject | CXCR4 | - |
dc.subject | Viral tropism | - |
dc.subject | Chemokines | - |
dc.subject | Estatinas | - |
dc.title | In vivo effect of statins on the expression of the HIV co-receptors CCR5 and CXCR4 | spa |
dc.type | info:eu-repo/semantics/article | spa |
dc.publisher.group | Inmunovirología | spa |
dc.identifier.doi | 10.1186/1742-6405-10-10 | - |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
dc.identifier.eissn | 1742-6405 | - |
oaire.citationtitle | AIDS Research and Therapy | spa |
oaire.citationstartpage | 1 | spa |
oaire.citationendpage | 12 | spa |
oaire.citationvolume | 10 | spa |
oaire.citationissue | 1 | spa |
dc.rights.creativecommons | https://creativecommons.org/licenses/by/4.0/ | spa |
dc.publisher.place | Reino Unido | spa |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
dc.type.redcol | https://purl.org/redcol/resource_type/ART | spa |
dc.type.local | Artículo de investigación | spa |
dc.relation.ispartofjournalabbrev | AIDS Res Ther | spa |
Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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HiguitaEdwinAndres_2013_VivoEffectsStatins.pdf | Artículo de Revista | 538.47 kB | Adobe PDF | Visualizar/Abrir |
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