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Título : BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice
Autor : Villamil Ortiz, Javier Gustavo
Barrera Ocampo, Álvaro Andrés
Piedrahita, Diego
Velásquez Rodríguez, Claudia María
Arias Londoño, Julián David
Cardona Gómez, Gloria Patricia
Palabras clave : Enfermedad de Alzheimer
Cognitivismo
Fosfolípidos
Funciones cognitivas
Interferencia de ARN
Fecha de publicación : 2016
Editorial : Frontiers Research Foundation
Citación : Villamil-Ortiz J, Barrera-Ocampo A, Piedrahita D, Velásquez-Rodríguez C, Arias-Londoño J, Cardona-Gómez G. BACE1 RNAi restores the composition of phosphatidylethanolamine-derivates related to memory improvement in aged 3xTg-AD mice. Frontiers in Cellular Neuroscience. 2016; 10(260): 1-14.
Abstract : β-amyloid (Aβ) is produced by the β-secretase 1 (BACE1)-mediated enzymatic cleavage of the amyloid precursor protein through the amyloidogenic pathway, making BACE1 a therapeutic target against Alzheimer’s disease (AD). Alterations in lipid metabolism are a risk factor for AD by an unknown mechanism. The objective of this study was to determine the effect of RNA interference against BACE1 (shBACEmiR) on the phospholipid profile in hippocampal CA1 area in aged 3xTg-AD mice after 6 and 12 months of treatment compared to aged PS1KI mice. The shBACEmiR treatment induced cognitive function recovery and restored mainly the fatty acid composition of lysophosphatidylethanolamine and etherphosphatidylethanolamine, reduced the cPLA2’s phosphorylation, down-regulated the levels of arachidonic acid and COX2 in the hippocampi of 3xTg-AD mice. Together, our findings suggest, for the first time, that BACE1 silencing restores phospholipids composition which could favor the recovery of cellular homeostasis and cognitive function in the hippocampus of triple transgenic AD mice. Keywords: Alzheimer’s disease, phospholipids, BACE1, RNA interference, hippocampus, cognitive function
Grupo de INV. : Grupo de Neurociencias de Antioquia
URI : http://hdl.handle.net/10495/8398
ISSN : 16625102
Aparece en las colecciones: CIA (Centro de Investigaciones Ambientales y de Ingeniería)

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