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Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/11716
Título : Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis
Autor : Corrales Bernal, Andrea
Jaramillo, Gabriela
Rodríguez, Berardo de Jesús
Yahia Kazuz, Elhadi
Maldonado Celis, María Elena
Palabras clave : Mangiferin indica
Colorectal cancer
Chemoprevention
Prostaglandin E2
Cytokines
Fecha de publicación : 2016
Editorial : United Arab Emirates University
Citación : Corrales-Bernal A, Jaramillo G, Rodríguez B, Yahia-Kazuz E, Maldonado-Celis M. Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogenesis. Emir J Food Agric. 2016; 28(10): 704-12 DOI: 10.9755/ejfa.2015-08-593
Abstract : Chemopreventive activities of natural compounds result in the modulation of several pathways and molecular targets. It is common to find effective potential candidates for cancer chemoprevention with anti-inflammatory properties. Mango (Mangifera indica cv. Azúcar) has shown anticarcinogenic effects and it is a source of bioactive compounds. This study evaluated the effects of mango on Aberrant Crypt Foci formation and inflammatory biomarkers after initiation of colon carcinogenesis in AOM-treated mice. Ripped mango pulp (Mangifera indica cv. Azúcar) composition was identified by HPLC. Azoxymethane-treated mice received the fruit (0.3% w/v) for eight weeks and the distal part of colon was collected and stained with methylene blue to look for aberrant crypt foci (ACF); scrapped mucosal cells were processed for prostaglandin E2 detection by ELISA; and blood levels of pro-inflammatory cytokines (interleukin-1Beta, tumor necrosis factor-alpha, interleukin 6) were also assessed by ELISA. Student’s t.test was used for the comparisons between mango treated and untreated groups. ACF formation was reduced by 67.5% and prostaglandin E2 levels were also reduced in mice which ingested the fruit. Cytokines levels were unchanged by mango consumption. In the chromatography were identified phenolic acids and Beta-carotene. Mango pulp showed chemopreventive effects through the reduction of ACF formation, by means of blocking hyperproliferation which is correlated with decreasing levels of PGE2.
Grupo de INV. : Impacto de Componentes Alimentarios en la Salud
URI : http://hdl.handle.net/10495/11716
ISSN : 2079052X
20790538 E
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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