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Título : Biological activity of Passiflora edulis f. Flavicarpa ethanolic leaves extract on human colonic adenocarcinoma cells
Autor : Ramírez, Valentina
Arango Varela, Sandra Sulay
Maldonado Celis, María Elena
Uribe, Diego
Aguillón Osma, Johanny
Quintero, Jenny Paola
Loango Chamorro, Nelsy
Palabras clave : Passiflora edulis
Phytochemicals
Anticancer potential
Colorectal cancer
Fecha de publicación : 2019
Editorial : Open Science Publishers LLP
Citación : Ramírez V, Arango SS, Maldonado ME, Uribe D, Aguillón J, Quintero JP, Loango N. Biological activity of Passiflora edulis f. Flavicarpa ethanolic leaves extract on human colonic adenocarcinoma cells. J Appl Pharm Sci. 2019; 9(2):64–71. DOI: 10.7324/JAPS.2019.90209
Abstract : Studies of extracts and phytochemicals from Passiflora genus have shown promissory biological activity for cancer chemoprevention; thus, in this work, it was evaluated the anticancer potential of the ethanolic extract of Passiflora edulis f. Flavicarpa leaves over Caco-2 and SW480 colorectal adenocarcinoma cells. The effect of the extract on cell viability was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and its antiproliferative activity was assessed by clonogenic assays. In addition, by flow cytometry approaches, it was evaluated the apoptosis-inducing effect and cell cycle regulation. In this way, it was established the half maximal inhibitory concentration (IC50) of the extract over both cell lines and also, it was observed the inhibition of cellular proliferation after 48 hours of exposure to the extract. On the other hand, we observed that the extract induced cell death-mechanisms, by the increasing of the proportion of necrotic and apoptotic cells; furthermore, the extract altered the distribution of cell cycle phases by increasing SubG1 and G2/M populations. Altogether, these results suggest that P. edulis is a potential source of phytochemical compounds with anticancer properties for the management of colorectal cancer patients.
Grupo de INV. : Impacto de Componentes Alimentarios en la Salud
URI : http://hdl.handle.net/10495/11990
ISSN : 22313354
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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