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Título : Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face
Autor : Quinto Sánchez, Mirsha
Muñoz Muñoz, Francesc
Gómez Valdés, Jorge
Cintas, Celia
Navarro, Pablo
Silva de Cerqueira, Caio César
Paschetta, Carolina
de Azevedo, Soledad
Ramallo, Virginia
Acuña Alonzo, Víctor
Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Hünemeier, Tábita
Everardo, Paola
de Ávila, Francisco
Jaramillo, Claudia
Arias, Williams
Gallo, Carla
Poletti, Giovani
Bedoya, Gabriel
Bortolini, Maria Cátira
Canizales Quinteros, Samuel
Rothhammer, Francisco
Rosique Gracia, Javier
Ruiz Linares, Andrés
González José, Rolando
metadata.dc.subject.*: Rostro humano
Modularidad
Antropología biológica
Evolutionary biology
Biological anthropology
Fecha de publicación : 2018
Editorial : Nature Research
Citación : Quinto, M., Muñoz, F., Gómez, J., Cintas, C., Navarro, P., Silva, C., ... González, R. (2018). Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face. Scientific Reports, 8, 1-15.
Resumen : ABSTRACT: Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes.
metadata.dc.identifier.eissn: 2045-2322
Aparece en las colecciones: CISH (Centro de Investigaciones Sociales y Humanas)

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