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dc.contributor.authorPérez Cardona, Juan Manuel-
dc.contributor.authorMaldonado Celis, María Elena-
dc.contributor.authorRojano, Benjamín Alberto-
dc.contributor.authorAlzate Guarín, Fernando-
dc.contributor.authorSáez Vega, Jairo-
dc.contributor.authorCardona Galeano, Wilson-
dc.date.accessioned2019-09-27T18:45:58Z-
dc.date.available2019-09-27T18:45:58Z-
dc.date.issued2014-
dc.identifier.citationPérez-Cardona J, Maldonado-Celis M, Rojano B, Alzate-Guarín F, Sáez-Vega J, Cardona-Galeano W. Comparative antioxidant, antiproliferative and apoptotic effects of Ilex laurina and Ilex paraguariensis on colon cancer cells. Trop J Pharm Res. 2014; 13(8): 1279-86. DOI: 10.4314/tjpr.v13i8.12es_ES
dc.identifier.issn15965996-
dc.identifier.issn15969827 E-
dc.identifier.urihttp://hdl.handle.net/10495/12041-
dc.description.abstractPurpose: To determine and compare the antioxidant, antiproliferative and apoptotic effects of leaf infusions of Ilex laurina and Ilex paraguariensis in colon cancer cells. Methods: Antioxidant activity was determined by ORAC (Oxygen Radical Absorbance Capacity) and FRAP (Ferric Reducing Antioxidant Power). Cytotoxic and antiproliferative effects were analyzed using MTT ((3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) and sulfhorodamine-B respectively. Cell death and apoptosis of human colon adenocarcinoma cells SW480 and their metastatic-derived SW620 cells, were analyzed by flow cytometry using propidium iodide and Annexin-V. Results: Although their flavonoid levels were similar, I. laurina infusion contained 2.2 and 4.4 times higher amounts of total phenolic and caffeoyl derivatives, respectively, than I. paraguariensis. FRAP and ORAC values for I. laurina infusion were 1.6 and 2.0 more active than I. paraguariensis. Both plant infusions inhibited viability and cell growth of SW480 and SW620 cells. These results may be associated to cell cycle-arrest and apoptosis because of the comparable increase of hypodiploid and annexin-V positive colon cancer cells. Conclusion: These data highlight the antioxidant and promising anticancer activities of I. laurina and Ilex paraguariensis.es_ES
dc.format.extent1279-1286es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenes_ES
dc.publisherUniversity of Benines_ES
dc.type.hasversioninfo:eu-repo/semantics/publishedVersiones_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.sourceinstname: Universidad de Antioquiaes_ES
dc.sourcereponame: Repositorio Institucional Universidad de Antioquiaes_ES
dc.sourceTropical Journal of Pharmaceutical Researches_ES
dc.subjectIlex laurinaes_ES
dc.subjectIlex paraguariensises_ES
dc.subjectAntioxidantes_ES
dc.subjectAntiproliferativees_ES
dc.subjectApoptosises_ES
dc.subjectColon canceres_ES
dc.titleComparative antioxidant, antiproliferative and apoptotic effects of Ilex laurina and Ilex paraguariensis on colon cancer cellses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.publisher.groupGrupo de Estudios Botánicoses_ES
dc.publisher.groupImpacto de Componentes Alimentarios en la Saludes_ES
dc.relation.volumen13es_ES
dc.relation.numero8es_ES
dc.source.tituloRevistaAbreviadaTrop J Pharm Reses_ES
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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