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Título : Effects of step-wise increases in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome
Autor : Volk, Brittanie M.
Kunces, Laura J.
Freidenreich, Daniel J.
Kupchak, Brian R.
Sáenz, Catherine
Artistizábal Rivera, Juan Carlos
Fernández, María Luz
Bruno, Richard S.
Maresh, Carl M.
Kraemer, William J.
Phinney, Stephen D.
Volek, Jeff S.
Fecha de publicación : 2014
Editorial : Plos
Citación : Volk BM, Kunces LJ, Freidenreich DJ, Kupchak BR, Sáenz C, et al. Effects of step-wise increases in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome. PLoS ONE. 2014; 9(11): DOI: 10.1371/journal.pone. 0113605
Abstract : Recent meta-analyses have found no association between heart disease and dietary saturated fat; however, higher proportions of plasma saturated fatty acids (SFA) predict greater risk for developing type-2 diabetes and heart disease. These observations suggest a disconnect between dietary saturated fat and plasma SFA, but few controlled feeding studies have specifically examined how varying saturated fat intake across a broad range affects circulating SFA levels. Sixteen adults with metabolic syndrome (age 44.9¡9.9 yr, BMI 37.9¡6.3 kg/m2) were fed six 3-wk diets that progressively increased carbohydrate (from 47 to 346 g/day) with concomitant decreases in total and saturated fat. Despite a distinct increase in saturated fat intake from baseline to the low-carbohydrate diet (46 to 84 g/day), and then a gradual decrease in saturated fat to 32 g/day at the highest carbohydrate phase, there were no significant changes in the proportion of total SFA in any plasma lipid fractions. Whereas plasma saturated fat remained relatively stable, the proportion of palmitoleic acid in plasma triglyceride and cholesteryl ester was significantly and uniformly reduced as carbohydrate intake decreased, and then gradually increased as dietary carbohydrate was re-introduced. The results show that dietary and plasma saturated fat are not related, and that increasing dietary carbohydrate across a range of intakes promotes incremental increases in plasma palmitoleic acid, a biomarker consistently associated with adverse health outcomes.
Grupo de INV. : Grupo de Investigación en Fisiología y Bioquímica - Physis
URI : http://hdl.handle.net/10495/12060
ISSN : 19326203
Aparece en las colecciones: CIAN (Centro de Investigación en Alimentación y Nutrición)

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