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https://hdl.handle.net/10495/20639| Título : | Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA |
| Autor : | Cienfuegos Gallet, Astrid Vanessa Chen, Liang Kreiswirth, Barry Jimenes Quiceno, Judy Natalia |
| metadata.dc.subject.*: | Klebsiella pneumoniae Colistina Colistin Enterobacteriaceae Resistentes a los Carbapenémicos Carbapenem-Resistant Enterobacteriaceae |
| Fecha de publicación : | 2017 |
| Editorial : | American Society for Microbiology |
| Resumen : | ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA. |
| metadata.dc.identifier.eissn: | 1098-6596 |
| ISSN : | 0066-4804 |
| metadata.dc.identifier.doi: | 10.1128/AAC.00404-17 |
| Aparece en las colecciones: | Artículos de Revista en Microbiología |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| CienfuegosAstrid_2017_ColistinChromosomalDNA.pdf | Artículo de investigación | 159.31 kB | Adobe PDF | Visualizar/Abrir |
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