Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/23669
Título : Antitumor and Antiviral Activity of Colombian Medicinal Plant
Autor : Betancur Galvis, Liliana Amparo
Saéz Vega, Jairo Antonio
Granados Niño, Hillmer
Salazar, A
Ossa Londoño, Jorge Eliécer
metadata.dc.subject.*: Etnobotánica
Ethnobotany
Plantas medicinales
Medicinal plants
Antimicrobial properties
Propiedades antimicrobianas
Virus herpes simplex
Herpes simplex virus
Citotoxicidad
Citotoxicity
Ensayo colorimétrico
http://aims.fao.org/aos/agrovoc/c_24023
http://aims.fao.org/aos/agrovoc/c_2393
http://aims.fao.org/aos/agrovoc/c_26756
http://aims.fao.org/aos/agrovoc/c_37159
http://aims.fao.org/aos/agrovoc/c_34251
Fecha de publicación : 1999
Editorial : Instituto Oswaldo Cruz
Resumen : ABSTRACT: Extracts of nine species of plants traditionally used in Colombia for the treatment of a variety of diseases were tested in vitro for their potential antitumor (cytotoxicity) and antiherpetic activity. MTT (Tetrazolium blue) and Neutral Red colorimetric assays were used to evaluate the reduction of viability of cell cultures in presence and absence of the extracts. MTT was also used to evaluate the effects of the extracts on the lytic activity of herpes simplex virus type 2 (HSV-2). The 50% cytotoxic concentration (CC50) and the 50% inhibitory concentration of the viral effect (EC50) for each extract were calculated by linear regression analysis. Extracts from Annona muricata, A. cherimolia and Rollinia membranacea, known for their cytotoxicity were used as positive controls. Likewise, acyclovir and heparin were used as positive controls of antiherpetic activity. Methanolic extract from Annona sp. on HEp-2 cells presented a CC50 value at 72 hr of 49.6x103µg/ ml. Neither of the other extracts examined showed a significant cytotoxicity. The aqueous extract from Beta vulgaris, the ethanol extract from Callisia grasilis and the methanol extract Annona sp. showed some antiherpetic activity with acceptable therapeutic indexes (the ratio of CC50 to EC50). These species are good candidates for further activity-monitored fractionation to identify active principles.
metadata.dc.identifier.eissn: 1678-8060
ISSN : 0074-0276
metadata.dc.identifier.doi: 10.1590/S0074-02761999000400019
Aparece en las colecciones: Artículos de Revista en Ciencias Exactas y Naturales

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