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https://hdl.handle.net/10495/25207| Título : | Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| Autor : | Rojas Camargo, John Jairo Aristizábal, Julián Sánchez, Joan |
| metadata.dc.subject.*: | Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| Fecha de publicación : | 2013 |
| Editorial : | Academic Journals |
| Resumen : | ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components. |
| metadata.dc.identifier.eissn: | 1996-0816 |
| metadata.dc.identifier.doi: | 10.5897/AJPP2013.3466 |
| Aparece en las colecciones: | Artículos de Revista en Farmacéutica y Alimentarias |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| RojasJohn_2013_AssessmentModifiedVerapamil.pdf | Artículo de investigación | 521.62 kB | Adobe PDF | Visualizar/Abrir |
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