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https://hdl.handle.net/10495/25225| Título : | Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms |
| Autor : | Valle Agudelo, Gustavo del Estrada, Ricardo Valderrama Hernández, Rafael Robles, Abel Osorio Gutiérrez, Raúl Guillermo Gutiérrez Gutiérrez, José María Otero Patiño, Rafael Giraldo, César Augusto Núñez Rangel, Vitelbina |
| metadata.dc.subject.*: | Bothrops Venenos de Serpiente Snake Venoms Neutralización Neutralization Antioquia (Colombia) Chocó (Colombia) |
| Fecha de publicación : | 1997 |
| Editorial : | Associação Brasileira de Divulgação Científica |
| Citación : | Otero R, Núñez V, Gutiérrez J, Robles A, Estrada R, Osorio R, Del-Valle G, et al. Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms. Braz J Med Biol Res1997;30(3):375-9. |
| Resumen : | ABSTRACT: Three horse-derived antivenoms were tested for their ability to neu-tralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxicactivitiesinduced by the venom of Bothrops atrox from Antioquia andChocó (Colombia). The following antivenoms were used: a) polyva-lent (crotaline) antivenom produced by Instituto Clodomiro Picado(Costa Rica), b) monovalent antibothropic antivenom produced byInstituto Nacional de Salud-INS (Bogotá), and c) a new monovalentanti-B. atrox antivenom produced with the venom of B. atrox fromAntioquia and Chocó. The three antivenoms neutralized alltoxicactivitiestested albeit with different potencies. The new monovalentanti-B. atrox antivenomshowed the highest neutralizing ability againstedema-forming and defibrinating effects of B. atrox venom (41 ± 2and 100 ± 32 μl antivenom/mgvenom, respectively), suggesting thatitshould be usefulin the treatment of B. atrox envenomation inAntioquia and Chocó. |
| metadata.dc.identifier.eissn: | 1414-431X |
| ISSN : | 0100-879X |
| metadata.dc.identifier.doi: | 10.1590/S0100-879X1997000300011 |
| Aparece en las colecciones: | Artículos de Revista en Farmacéutica y Alimentarias |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| DelValleGustavo_1997_NeutralizingCapacityMonovalent.pdf | Artículo de investigación | 319.73 kB | Adobe PDF | Visualizar/Abrir |
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