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https://hdl.handle.net/10495/25260Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Muñoz Herrera, Diana Lorena | - |
| dc.contributor.author | Cardona Sánchez, Diana Patricia | - |
| dc.contributor.author | Cardona, Álvaro | - |
| dc.contributor.author | Carrillo Bonilla, Lina María | - |
| dc.contributor.author | Quiñones Fletcher, Winston | - |
| dc.contributor.author | Echeverri López, Luis Fernando | - |
| dc.contributor.author | Vélez Bernal, Iván Darío | - |
| dc.contributor.author | Robledo Restrepo, Sara María | - |
| dc.date.accessioned | 2022-01-14T13:48:42Z | - |
| dc.date.available | 2022-01-14T13:48:42Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.citation | Muñoz, D., Cardona, D., Cardona, Á., Carrillo, L., Quiñones, W., Echeverri, F., Vélez, I., & Robledo, S. (2006). Efecto de hidrazonas sobre amastigotes intracelulares de Leishmania panamensis y una proteasa de cisteína parasitaria. Vitae , 13 (2). Obtenido de https://revistas.udea.edu.co/index.php/vitae/article/view/548 | spa |
| dc.identifier.issn | 0121-4004 | - |
| dc.identifier.uri | http://hdl.handle.net/10495/25260 | - |
| dc.description.abstract | RESUMEN: En este trabajo se describe la síntesis de hidrazonas derivadas de cromano, tiocromano, alquil y aril hidrazonas, su actividad leishmanicida y su efecto sobre proteasas de cisteína de L. (V) panamensis. Se sintetizan feniltiocromanos y bencil y naftil derivados; solamente las fenilhidrazonas muestran alguna actividad sobre amastigotes de Leishmnia (V) panamensis. No se observa ningún efecto sobre una proteasa de cisteína del parásito lo que sugiere un mecanismo de acción diferente a la inhibición de esta enzima. | spa |
| dc.description.abstract | ABSTRACT: In this paper, the synthesis of hydrazones derived from cromano, thiocroman, alkyl and aril hydra-zones is described, as well as their leishmanicidal activity and their effect on cysteine proteases fromL. (V) panamensis. A series of novel phenylthiochromane and benzyl and naphtyl derivatives are synthesized and evaluated for their cytotoxic and antileishmanial activities. Their effect on parasite cysteine protease is also evaluated. Only phenylthiochromane derivatives display some activity againstLeishmania (V) panamensisbut all compounds are inactive against parasitic cystein protease. These results may suggest a different mechanism of action for these compounds. | spa |
| dc.format.extent | 8 | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | spa | spa |
| dc.publisher | Universidad de Antioquia, Facultad de Ciencias Farmacéuticas y Alimentarias | spa |
| dc.type.hasversion | info:eu-repo/semantics/publishedVersion | spa |
| dc.rights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/2.5/co/ | * |
| dc.title | Efecto de hidrazonas sobre amastigotes intracelulares de Leishmania panamensis y una proteasa de cisteína parasitaria | spa |
| dc.title.alternative | Effect of hydrazones against intracellular amastigotes of Leishmania panamensis and a parasitic cystein protease | spa |
| dc.type | info:eu-repo/semantics/article | spa |
| dc.publisher.group | Programa de Estudio y Control de Enfermedades Tropicales (PECET) | spa |
| dc.publisher.group | Química Orgánica de Productos Naturales | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| dc.rights.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |
| dc.identifier.eissn | 2145-2660 | - |
| oaire.citationtitle | Vitae | spa |
| oaire.citationstartpage | 5 | spa |
| oaire.citationendpage | 12 | spa |
| oaire.citationvolume | 13 | spa |
| oaire.citationissue | 2 | spa |
| dc.rights.creativecommons | https://creativecommons.org/licenses/by-nc-sa/4.0/ | spa |
| dc.publisher.place | Medellín, Colombia | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
| dc.type.redcol | https://purl.org/redcol/resource_type/ART | spa |
| dc.type.local | Artículo de investigación | spa |
| dc.subject.decs | Hidrazonas | - |
| dc.subject.decs | Hydrazones | - |
| dc.subject.decs | Proteasas de Cisteína | - |
| dc.subject.decs | Cysteine Proteases | - |
| dc.subject.agrovoc | Síntesis | - |
| dc.subject.agrovoc | Synthesis | - |
| dc.subject.agrovoc | Leishmania | - |
| dc.subject.proposal | Efecto leishmanicida | spa |
| dc.subject.agrovocuri | http://aims.fao.org/aos/agrovoc/c_3def4163 | - |
| dc.subject.agrovocuri | http://aims.fao.org/aos/agrovoc/c_24350 | - |
| dc.identifier.url | https://revistas.udea.edu.co/index.php/vitae/article/view/548/ | spa |
| dc.description.researchgroupid | COL0015339 | spa |
| dc.description.researchgroupid | COL0015099 | spa |
| dc.relation.ispartofjournalabbrev | Vitae | spa |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Exactas y Naturales | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| MuñozDiana_2006_HidrazonasAmastigotesLeishmania.pdf | Artículo de investigación | 110.27 kB | Adobe PDF | Visualizar/Abrir |
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