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dc.contributor.authorGaly, Oliver-
dc.contributor.authorChemin, Isabelle-
dc.contributor.authorLe Roux, Emilie-
dc.contributor.authorVillar, Stephanie-
dc.contributor.authorLe Calvez Kelm, Florence-
dc.contributor.authorLereau, Myriam-
dc.contributor.authorGouas, Doriane-
dc.contributor.authorVieco, Beatriz-
dc.contributor.authorSuárez Mellado, Iris-
dc.contributor.authorNavas Navas, María Cristina-
dc.contributor.authorChevallier, Michele-
dc.contributor.authorNorder, Helene-
dc.contributor.authorSrivatanakul, Petcharin-
dc.contributor.authorKaralak, Anant-
dc.contributor.authorSangrajrang, Suleeporn-
dc.contributor.authorTrepo, Christian-
dc.contributor.authorHainaut, Pierre-
dc.date.accessioned2022-02-26T14:04:13Z-
dc.date.available2022-02-26T14:04:13Z-
dc.date.issued2011-
dc.identifier.issn2090-1364-
dc.identifier.urihttp://hdl.handle.net/10495/26208-
dc.description.abstractABSTRACT: Hepatocellular carcinoma (HCC) may develop according to two major pathways, one involving HBV infection and TP53 mutation and the other characterized by HCV infection and CTNNB1 mutation. We have investigated HBV/HCV infections and TP53/CTNNB1 mutations in 26 HCC patients from Thailand. HBV DNA (genotype B or C) was detected in 19 (73%) of the cases, including 5 occult infections and 3 coinfections with HCV. TP53 and CTNNB1 mutations were not mutually exclusive, and most of TP53 mutations were R249S, suggesting a significant impact of aflatoxin-induced mutagenesis in HCC development.spa
dc.format.extent10spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherHindawi Pub. Corp.spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleMutations in TP53 and CTNNB1 in Relation to Hepatitis B and C Infections in Hepatocellular Carcinomas from Thailandspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo de Gastrohepatologíaspa
dc.identifier.doi10.1155/2011/697162-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2090-1372-
oaire.citationtitleHepatitis Research and Treatmentspa
oaire.citationstartpage1spa
oaire.citationendpage10spa
oaire.citationvolume2011spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeNueva York, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsPatología Molecular-
dc.subject.decsPathology, Molecular-
dc.subject.decsVirus de la Hepatitis B-
dc.subject.decsHepatitis B virus-
dc.subject.decsGenes p53-
dc.subject.decsGenes, p53-
dc.subject.decsHepacivirus-
dc.description.researchgroupidCOL0024159spa
dc.relation.ispartofjournalabbrevHepat. Res. Treat.spa
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