Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count : Meta-analysis 1980-2018

Abstract

ABSTRACT : The efects of platelet donation by apheresis on diferent parameters of the erythrogram are still unclear. The objective was to meta-analyze the efect of plateletpheresis on hematocrit, hemoglobin, and erythrocyte count, with a systematic review with random efects meta-analysis of the mean diference. The PRISMA guidelines were considered, as well as 133 search strategies on four diferent databases. Reproducibility was guaranteed and methodological quality was evaluated. Heterogeneity was evaluated with Galbraith and DerSimonian-Laird’s, publication bias with a funnel plot and a Begg’s test, sensitivity analysis and a cumulative meta-analysis were also conducted. Eighteen (18) articles were included, 17 evaluated the efects on hematocrit in 2,564 donors; 13 on hemoglobin in 1,640 donors; and 4 on red blood cell count in 243 donors. A decrease of 2.26% (CI95%=2.11–2.41) was observed in hematocrit, of 0.80g/dL (CI95%=0.75–0.86) in hemoglobin and −0.21×1012/L (CI95%=−0.13; −0.29) in red blood cell count. Plateletpheresis has a negative efect on the erythrogram parameters, explained by blood loss in the kits used for the procedure and cell lysis. Such evidence is relevant to secure the efciency and safety of the procedure, improve selection processes or determine the number of donations that can be performed without afecting donors’ health.