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dc.contributor.authorNarváez Sánchez, Raúl-
dc.date.accessioned2022-10-12T02:41:51Z-
dc.date.available2022-10-12T02:41:51Z-
dc.date.issued2018-
dc.identifier.citationNarvaez-Sanchez R. Milestones and frontiers in vascular physiology in health and cancer. Iatreia [Internet]. 2 de febrero de 2018 [citado 11 de octubre de 2022];31(1-S):S14. Disponible en: https://revistas.udea.edu.co/index.php/iatreia/article/view/329904spa
dc.identifier.issn0121-0793-
dc.identifier.urihttps://hdl.handle.net/10495/31258-
dc.description.abstractABSTRACT: Cardiovascular diseases are the main cause of death in the world: ischemic heart disease (IHD) and stroke account for 30% of total deaths, remaining as leading causes of death globally in the last 15 years. Diabetes and cancer are the fifth and sixth causes of death; those four diseases totaled more than 18 million of deaths in 2015. Cancer depends on vessels too, needing angiogenesis to grow and metastasis. From another point of view, vascular diseases manifest interestingly during pregnancy, where arterial pressure and/or body composition abnormalities manifest with different intensity among patients: hypertension (called preeclampsia, PE), excessive gestational weight gain (EGWG) and gestational diabetes mellitus (GDM). All the listed abnormalities share common pathophysiological pathways with a low grade inflammatory basis which generates oxidative stress, being the vessel wall the final common pathway for the impact of cardiovascular risk factors and genetic predisposition to metabolic, hypertensive and ischemic diseases, inducing the endothelial dysfunction which underlies most of the clinical and paraclinical findings. Vessel wall is an organ with huge paracrine, endocrine and autocrine activity, then its affectation could be not only a consequence but the cause in those pathologies. It is mandatory to research in vascular wall physiology and pathophysiology to understand such disorders and, optimally, to prevent them and their related, as well as to design more precise therapies and consequently to diminish the associated morbidity, mortality and costs. Milestones in vascular physiology will be presented from William Harvey until our days, and frontiers in research emphasizing in health and cancer of mesenteric and placental beds, and the looking for evidences of a muscle-adipocyte-endothelium axis. Those are the challenges for The Vascular Physiology section of the PHYSIS lab at the University of Antioquia. As a conclusion, our lines and preliminary results of research in vascular reactivity, cancer, angiogenesis, PE, EGWG and GDM, and the scientific nets we are working on, will be shown and discussed.spa
dc.format.extent1spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherUniversidad de Antioquia, Facultad de Medicinaspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.titleMilestones and frontiers in vascular physiology in health and cancerspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo de Investigación en Fisiología y Bioquímica - Physisspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2011-7965-
oaire.citationtitleIatreiaspa
oaire.citationstartpage14spa
oaire.citationendpage14spa
oaire.citationvolume31spa
oaire.citationissueSuplemento 1spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.publisher.placeMedellín, Colombiaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_6501spa
dc.type.redcolhttp://purl.org/redcol/resource_type/CJournalArticlespa
dc.type.localArtículo de revistaspa
dc.subject.decsEnfermedades Cardiovasculares-
dc.subject.decsCardiovascular Diseases-
dc.subject.decsIsquemia Miocárdica-
dc.subject.decsMyocardial Ischemia-
dc.identifier.urlhttps://revistas.udea.edu.co/index.php/iatreia/article/view/329904/0spa
dc.description.researchgroupidCOL0007328spa
dc.relation.ispartofjournalabbrevIatreiaspa
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