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dc.contributor.authorDiosa Toro, Mayra Alejandra-
dc.contributor.authorVelilla hernandez, Paula Andrea-
dc.contributor.authorRugeles López, María Teresa-
dc.contributor.authorJaimes Barragán, Fabián Alberto-
dc.date.accessioned2022-10-13T14:23:44Z-
dc.date.available2022-10-13T14:23:44Z-
dc.date.issued2013-
dc.identifier.issn0123-9392-
dc.identifier.urihttps://hdl.handle.net/10495/31310-
dc.description.abstractABSTRACT: Introduction: The mechanisms involved in the immunopathogenesis of sepsis are not well established. The clinical and therapeutic relevance of several soluble mediators has been described and the contribution of cellular components with immunoregulatory roles has begun to be elucidated. Objective: To describe changes in the frequency and production of IFN-γ and IL-10 occurring in NK cells and γδ T lymphocytes in a cohort of patients with different manifestations of septic syndrome. Materials and methods: This was a prospective cohort study. Patients with sepsis (n=26), and severe sepsis (n=83) from adult emergency rooms and intensive care units, as well as healthy volunteers (n=8), were included. For all participants, the frequency and phenotype of NK cells and γδ T lymphocytes and the percentage of IFN-γ and IL-10 positive NK and γδ T cells were evaluated by flow cytometry. The NK cells were phenotyped based on the expression of CD56 and CD16 and the γδ T cells on the expression of δ1 and δ2 chains. Results: Patients with sepsis and severe sepsis exhibited an increase in the frequency of NK cells with changes in the proportion of the CD56bright/CD16¯, CD56bright/CD16dim and CD56dimCD16¯ subpopulations; these cells showed a proinflammatory cytokine profile. A decrease in the Vδ2 subset of γδ T lymphocytes was also observed. Conclusions: Our results indicate a role for NK and γδT cells during sepsis, however, their exact contribution in the pathogenesis of sepsis syndrome requires further studies.spa
dc.format.extent8spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherAsociación Colombiana de Infectologíaspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleIncreased frequency of NK and gamma delta 1 T cells in a cohort of patients with sepsisspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo Académico de Epidemiología Clínicaspa
dc.publisher.groupInmunovirologíaspa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2422-3794-
oaire.citationtitleInfectiospa
oaire.citationstartpage177spa
oaire.citationendpage184spa
oaire.citationvolume17spa
oaire.citationissue4spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeBogotá, Colombiaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsSepsis-
dc.subject.decsKiller Cells, Natural-
dc.subject.decsCélulas Asesinas Naturales-
dc.subject.decsIntraepithelial Lymphocytes-
dc.subject.decsLinfocitos Intraepiteliales-
dc.subject.decsImmunomodulation-
dc.subject.decsInmunomodulación-
dc.subject.decsInterferon-gamma-
dc.subject.decsInterferón gamma-
dc.subject.decsInterleukin-10-
dc.subject.decsInterleucina-10-
dc.description.researchgroupidCOL0012444spa
dc.description.researchgroupidCOL0007121spa
dc.relation.ispartofjournalabbrevInfectiospa
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