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dc.contributor.authorSáez Vega, Jairo Antonio-
dc.contributor.authorFrappier, Francois-
dc.contributor.authorJossang, Akino-
dc.contributor.authorSoudon, Jacques-
dc.contributor.authorCalvo, Fabien-
dc.contributor.authorRasoanaivo, Philippe-
dc.contributor.authorRatsimamanga Urverg, Suzanne-
dc.contributor.authorSchrevel, Joseph-
dc.contributor.authorGrellier, Philippe-
dc.date.accessioned2023-02-09T18:24:11Z-
dc.date.available2023-02-09T18:24:11Z-
dc.date.issued1996-
dc.identifier.citationFrappier F, Jossang A, Soudon J, Calvo F, Rasoanaivo P, Ratsimamanga-Urverg S, Saez J, Schrevel J, Grellier P. Bisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells. Antimicrob Agents Chemother. 1996 Jun;40(6):1476-81. doi: 10.1128/AAC.40.6.1476.spa
dc.identifier.issn0066-4804-
dc.identifier.urihttps://hdl.handle.net/10495/33431-
dc.description.abstractABSTRACT: Ten naturally occurring bisbenzylisoquinolines (BBIQ) and two dihydro derivatives belonging to five BBIQ subgroups were evaluated in vitro for their ability to inhibit Plasmodium falciparum growth and, in drug combination, to reverse the resistance to chloroquine of strain FcB1. The same alkaloids were also assessed in vitro for their potentiating activity against vinblastine with the multidrug-esistant clone CCRF-CEM/VLB, established from lymphoblastic acute leukemia. Three of the BBIQ tested had 50% inhibitory concentrations of less than 1 mM. The most potent antimalarial agent was cocsoline (50% inhibitory concentration, 0.22 mM). Regarding the chloroquine-potentiating effect, fangchinoline exhibited the highest biological activity whereas the remaining compounds displayed either antagonistic or slight synergistic effects. Against the multidrugresistant cancer cell line, fangchinoline was also by far the most active compound. Although there were clear differences between the activities of tested alkaloids, no relevant structure-activity relationship could be established. Nevertheless, fangchinoline appears to be a new biochemical tool able to help in the comprehension of the mechanism of both chloroquine resistance in P. falciparum and multidrug resistance in tumor cells.spa
dc.format.extent6spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherAmerican Society for Microbiologyspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.titleBisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cellsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupQuímica de Plantas Colombianasspa
dc.identifier.doi10.1128/AAC.40.6.1476.-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1098-6596-
oaire.citationtitleAntimicrobial Agents and Chemotherapyspa
oaire.citationstartpage1476spa
oaire.citationendpage1481spa
oaire.citationvolume40spa
oaire.citationissue6spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeWashington, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsAntimaláricos-
dc.subject.decsAntimalarials-
dc.subject.decsCloroquina-
dc.subject.decsChloroquine-
dc.subject.decsFarmacorresistencia Microbiana-
dc.subject.decsDrug Resistance, Microbial-
dc.subject.decsResistencia a Múltiples Medicamentos-
dc.subject.decsDrug Resistance, Multiple-
dc.subject.decsSinergismo Farmacológico-
dc.subject.decsDrug Synergism-
dc.subject.decsPlasmodium falciparum-
dc.subject.decsLeucemia-Linfoma Linfoblástico de Células T Precursoras-
dc.subject.decsPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.decsRelación Estructura-Actividad-
dc.subject.decsStructure-Activity Relationship-
dc.subject.decsCélulas Tumorales Cultivadas-
dc.subject.decsTumor Cells, Cultured-
dc.description.researchgroupidCOL0015329spa
dc.relation.ispartofjournalabbrevAntimicrob. Agents. Chemother.spa
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