1. Repositorio Institucional Universidad de Antioquia
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  3. CIEN (Centro de Investigaciones en Ciencias Exactas y Naturales)
  4. Artículos de Revista en Ciencias Exactas y Naturales
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/34948
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dc.contributor.authorJaramillo Alzate, Claudia Milena-
dc.contributor.authorAdhikari, Kaustubh-
dc.contributor.authorFontanil, Tania-
dc.contributor.authorCal, Santiago-
dc.contributor.authorMendoza Revilla, Javier-
dc.contributor.authorFuentes Guajardo, Macarena-
dc.contributor.authorChacón Duque, Juan Camilo-
dc.contributor.authorAl Saadi, Farah-
dc.contributor.authorJohansson, Jeanette A-
dc.contributor.authorQuinto Sanchez, Mirsha-
dc.contributor.authorAcuña Alonzo, Victor-
dc.contributor.authorArias Pérez, William Hernán-
dc.contributor.authorBarquera Lozano, Rodrigo-
dc.contributor.authorMacín Pérez, Gastón-
dc.contributor.authorGómez Valdés, Jorge-
dc.contributor.authorVillamil Ramírez, Hugo-
dc.contributor.authorHunemeier, Tábita-
dc.contributor.authorRamallo, Virginia-
dc.contributor.authorSilva de Cerqueira, Caio C.-
dc.contributor.authorHurtado, Malena-
dc.contributor.authorVillegas, Valeria-
dc.contributor.authorGranja, Vanessa-
dc.contributor.authorGallo, Carla-
dc.contributor.authorPoletti, Giovanni-
dc.contributor.authorSchuler Faccini, Lavinia-
dc.contributor.authorSalzano, Francisco M.-
dc.contributor.authorBortolini, Maria Cátira-
dc.contributor.authorCanizales Quinteros, Samuel-
dc.contributor.authorRothhammer, Francisco-
dc.contributor.authorBedoya Berrío, Gabriel de Jesús-
dc.contributor.authorGonzález José, Rolando-
dc.contributor.authorHeadon, Denis-
dc.contributor.authorLópez Otín, Carlos-
dc.contributor.authorTobin, Desmond J.-
dc.contributor.authorBalding, David-
dc.contributor.authorRuiz Linares, Andrés-
dc.date.accessioned2023-05-10T16:47:35Z-
dc.date.available2023-05-10T16:47:35Z-
dc.date.issued2016-
dc.identifier.citationAdhikari K, Fontanil T, Cal S, Mendoza-Revilla J, Fuentes-Guajardo M, Chacón-Duque JC, Al-Saadi F, Johansson JA, Quinto-Sanchez M, Acuña-Alonzo V, Jaramillo C, Arias W, Barquera Lozano R, Macín Pérez G, Gómez-Valdés J, Villamil-Ramírez H, Hunemeier T, Ramallo V, Silva de Cerqueira CC, Hurtado M, Villegas V, Granja V, Gallo C, Poletti G, Schuler-Faccini L, Salzano FM, Bortolini MC, Canizales-Quinteros S, Rothhammer F, Bedoya G, Gonzalez-José R, Headon D, López-Otín C, Tobin DJ, Balding D, Ruiz-Linares A. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features. Nat Commun. 2016 Mar 1;7:10815. doi: 10.1038/ncomms10815.spa
dc.identifier.urihttps://hdl.handle.net/10495/34948-
dc.description.abstractABSTRACT: We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of association reaching genome-wide significance (P values 5 10 8 to 3 10 119), including 10 novel associations. These include novel loci for scalp hair shape and balding, and the first reported loci for hair greying, monobrow, eyebrow and beard thickness. A newly identified locus influencing hair shape includes a Q30R substitution in the Protease Serine S1 family member 53 (PRSS53). We demonstrate that this enzyme is highly expressed in the hair follicle, especially the inner root sheath, and that the Q30R substitution affects enzyme processing and secretion. The genome regions associated with hair features are enriched for signals of selection, consistent with proposals regarding the evolution of human hair.spa
dc.format.extent12spa
dc.format.mimetypeapplication/pdfspa
dc.language.isospaspa
dc.publisherNature Researchspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleA genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair featuresspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.1038/ncomms10815-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2041-1723-
oaire.citationtitleNature Communicationsspa
oaire.citationstartpage1spa
oaire.citationendpage12spa
oaire.citationvolume7spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeLondres, Inglaterraspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsCara - fisiología-
dc.subject.decsFace - physiology-
dc.subject.decsRegulación de la Expresión Génica - fisiología-
dc.subject.decsGene Expression Regulation - physiology-
dc.subject.decsVariación Genética-
dc.subject.decsGenetic Variation-
dc.subject.decsEstudio de Asociación del Genoma Completo-
dc.subject.decsGenome-Wide Association Study-
dc.subject.decsCabello - crecimiento y desarrollo-
dc.subject.decsHair - growth and development-
dc.subject.decsGrupos Raciales-
dc.subject.decsRacial Groups-
dc.subject.decsCuero Cabelludo - fisiología-
dc.subject.decsScalp - physiology-
dc.description.researchgroupidCOL0006723spa
dc.relation.ispartofjournalabbrevNat. Commun.spa
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