1. Repositorio Institucional Universidad de Antioquia
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  3. Instituto de Investigaciones Médicas
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dc.contributor.authorBedoya Berrio, Gabriel De Jesus-
dc.contributor.authorRuiz Linares, Andrés-
dc.contributor.authorService, Susan-
dc.contributor.authorDeyoung, Joseph-
dc.contributor.authorKarayiorgou, María-
dc.contributor.authorPretoriuos, Herman-
dc.contributor.authorBedoya, Gabriel-
dc.contributor.authorOspina Duque, Jorge-
dc.contributor.authorMacedo, António-
dc.contributor.authorPalha, Joana Almeida-
dc.contributor.authorHeutink, Peter-
dc.contributor.authorAulchenko, Yurii-
dc.contributor.authorOostra, Ben-
dc.contributor.authorVan Duijn, Cornelia-
dc.contributor.authorJarvelin, Marjo Riitta-
dc.contributor.authorVarilo, Teppo-
dc.contributor.authorPeddle, Lynette-
dc.contributor.authorRahman, Proton-
dc.contributor.authorMurray, Sarah-
dc.contributor.authorGalver, Luana-
dc.contributor.authorPeltonen, Leena-
dc.contributor.authorSabatti, Chiara-
dc.contributor.authorCollins, Andrew-
dc.contributor.authorFreimer, Nelson-
dc.date.accessioned2023-08-30T13:46:33Z-
dc.date.available2023-08-30T13:46:33Z-
dc.date.issued2006-
dc.identifier.citationService S, DeYoung J, Karayiorgou M, Roos JL, Pretorious H, Bedoya G, Ospina J, Ruiz-Linares A, Macedo A, Palha JA, Heutink P, Aulchenko Y, Oostra B, van Duijn C, Jarvelin MR, Varilo T, Peddle L, Rahman P, Piras G, Monne M, Murray S, Galver L, Peltonen L, Sabatti C, Collins A, Freimer N. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet. 2006 May;38(5):556-60. doi: 10.1038/ng1770. Epub 2006 Apr 2. PMID: 16582909.spa
dc.identifier.issn1061-4036-
dc.identifier.urihttps://hdl.handle.net/10495/36450-
dc.description.abstractABSTRACT: The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping.spa
dc.format.extent5spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherNature Researchspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleMagnitude and distribution of linkage disequilibrium in population isolates and implications for genome - wide association studiesspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo de Investigación en Psiquiatría GIPSIspa
dc.identifier.doi10.1038/ng1770-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1546-1718-
oaire.citationtitleNature Geneticsspa
oaire.citationstartpage556spa
oaire.citationendpage560spa
oaire.citationvolume38spa
oaire.citationissue5spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeNueva York, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsCromosomas Humanos Par 22-
dc.subject.decsChromosomes, Human, Pair 22-
dc.subject.decsGenética de Población-
dc.subject.decsGenetics, Population-
dc.subject.decsGenoma Humano-
dc.subject.decsGenome, Human-
dc.subject.decsDesequilibrio de Ligamiento-
dc.subject.decsLinkage Disequilibrium-
dc.subject.decsPolimorfismo de Nucleótido Simple-
dc.subject.decsPolymorphism, Single Nucleotide-
dc.description.researchgroupidCOL0029147spa
dc.relation.ispartofjournalabbrevNat. Genet.spa
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