Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/37177
Título : Study of SARS-CoV-2 spike protein interaction with macrophages in presence of vitamin D
Autor : di Filippo Villa, Diana Carolina
Montoya Guzmán, Melissa
López Osorio, María Camila
Urcuqui Inchima, Silvio
Jaimes, Javier A.
Navas Navas, María Cristina
metadata.dc.subject.*: SARS-CoV-2
Macrófagos
Macrophages
Deficiencia de Vitamina D
Vitamin D Deficiency
metadata.dc.contributor.conferencename: Annual meeting of American Society for Virology (41 : Del 16 al 20 de julio de 2022, University of Wisconsin, Madison, Estados Unidos)
Fecha de publicación : 2022
Resumen : ABSTRACT: The macrophages are one of the most important cell populations playing a role in the development of the inflammatory response in SARS-CoV-2 infection. Indeed, the altered function of macrophages in cases of severe COVID-19 leads to a hyperactivated inflammatory response possibly due to damage of the respiratory tract epithelium and/or the interaction with viral particles through the recognition of the Toll-like receptors (TLR), even in the absence of active viral replication. Moreover, the activation and function modification of macrophages could be exacerbated in conditions of vitamin D deficiency, as described dengue virus infection.
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