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Título : | Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent |
Autor : | López Quintero, Juan Álvaro Peláez Sánchez, Ronald Guillermo Pereira, Martha María Arboleda Naranjo, Margarita Agudelo Flórez, Piedad |
metadata.dc.subject.*: | Leptospirosis Leptospira Colombia Tipificación de Secuencias Multilocus Multilocus Sequence Typing Técnicas de Tipificación Bacteriana Bacterial Typing Techniques Electroforesis en Gel de Campo Pulsado Electrophoresis, Gel, Pulsed-Field Variación Genética Genetic Variation ARN Ribosómico 16S RNA, Ribosomal, 16S https://id.nlm.nih.gov/mesh/D007922 https://id.nlm.nih.gov/mesh/D007919 https://id.nlm.nih.gov/mesh/D003105 https://id.nlm.nih.gov/mesh/D058885 https://id.nlm.nih.gov/mesh/D015373 https://id.nlm.nih.gov/mesh/D016521 https://id.nlm.nih.gov/mesh/D014644 https://id.nlm.nih.gov/mesh/D012336 |
Fecha de publicación : | 2016 |
Editorial : | Instituto Oswaldo Cruz |
Citación : | Peláez Sanchez RG, Lopez JÁ, Pereira MM, Arboleda Naranjo M, Agudelo-Flórez P. Genetic diversity of Leptospira in northwestern Colombia: first report of Leptospira santarosai as a recognised leptospirosis agent. Mem Inst Oswaldo Cruz. 2016 Dec;111(12):737-744. doi: 10.1590/0074-02760160245. Epub 2016 Nov 10. PMID: 27982303; PMCID: PMC5146737. |
Resumen : | ABSTRACT: The region of Antioquia in northeastern Colombia has the highest number of reported leptospirosis cases in the country. It also shows high seroprevalence indexes in the general population and socio-environmental conditions favourable for the transmission of the disease between humans and animals. In this study, 25 Leptospira isolates from Colombia’s Antioquia department were identified to the species level as L. santarosai (12), L. interrogans (9) and L. meyeri (4) using phylogenetic analysis of the Amidohydrolase gene. Typing at the serovar level was performed using multilocus sequence typing (MLST) and monoclonal antibodies. The serovars Canalzonae, Babudieri, Alice, Beye, and Copenhageni have been identified as causing human or animal infections in Antioquia, Colombia. The four environmental isolates were not identified to the serovar level. L. santarosai serovar Canalzonae and Alice were identified as new etiologic agents of human leptospirosis in Antioquia, Colombia. This paper reports species and serovars that were previously unknown in the region. |
metadata.dc.identifier.eissn: | 1678-8060 |
ISSN : | 0074-0276 |
metadata.dc.identifier.doi: | 10.1590/0074-02760160245 |
Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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LopezAlvaro_2016_Genetic_Leptospira_Colombia.pdf | Artículo de investigación | 438.39 kB | Adobe PDF | Visualizar/Abrir |
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