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Título : | Tuberculin skin test and CD4+/CD8+ T cell counts in adults infected with the human inmunodeficiency virus in Medellin, Colombia |
Autor : | Rodríguez Ospina, Jaime Iván Arias Pineda, Mauricio Alberto París Ángel, Sara Claudia Arbeláez Montoya, María Patricia Betancur, Julián García Moreno, Luis Fernando |
metadata.dc.subject.*: | Vacuna BCG BCG Vaccine Recuento de Linfocito CD4 CD4 Lymphocyte Count Relación CD4-CD8 CD4-CD8 Ratio Colombia - epidemiología Colombia - epidemiology Estudios de Seguimiento Follow-Up Studies Infecciones por VIH HIV Infections Prueba de Tuberculina Tuberculin Test https://id.nlm.nih.gov/mesh/D001500 https://id.nlm.nih.gov/mesh/D018791 https://id.nlm.nih.gov/mesh/D016516 https://id.nlm.nih.gov/mesh/D003105 https://id.nlm.nih.gov/mesh/D005500 https://id.nlm.nih.gov/mesh/D015658 https://id.nlm.nih.gov/mesh/D014374 |
Fecha de publicación : | 1997 |
Editorial : | Instituto Oswaldo Cruz |
Citación : | Rodríguez JI, Arias M, París SC, Arbeláez MP, Betancur J, García LF. Tuberculin skin test and CD4+/CD8+ T cell counts in adults infected with the human immunodeficiency virus in Medellín, Colombia. Mem Inst Oswaldo Cruz. 1997 Mar-Apr;92(2):245-50. doi: 10.1590/s0074-02761997000200018. PMID: 9332585. |
Resumen : | ABSTRACT: To evaluate the effect of BCG vaccination and T lymphocyte subpopulations on the reactivity to the tuberculin skin test, 113 asymptomatic HIV+ individuals were tuberculin tested by intradermal injection of 5TU of purified protein derivative and the levels of circulating lymphocyte (CD3, CD4 and CD8) subpopulations determined by indirect immunofluorescence. Ninety-two percent of the subjects included in the study were males. The mean age of the group was 32.1 +/- 7.4 years. Sixty-two percent presented a BCG scar. However, only 22% exhibited positive tuberculin reactions (> or = 5 mm) irrespective of the presence of the BCG scar. Tuberculin positive individuals exhibited higher CD4+ cell counts (p = 0.004) and CD4+/CD8+ ratios (p = 0.006) than tuberculin negative (< 5 mm) HIV+ individuals. The number of individuals with positive tuberculin reactions was significantly higher in subjects with more than 500 CD4+ lymphocytes/microliter (p = 0.02) or CD4+/CD8+ ratios > or = 1.12 (p = 0.002). These results suggest that a prior BCG vaccination does not influence the reactivity to the tuberculin skin test in HIV+ asymptomatic individuals and that the number of CD4+ lymphocytes and the CD4+/ CD8+ ratio positively correlate with the tuberculin reactivity. |
metadata.dc.identifier.eissn: | 1678-8060 |
ISSN : | 0074-0276 |
metadata.dc.identifier.doi: | 10.1590/s0074-02761997000200018. |
Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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RodriguezJaime_1997_Tuberculin_Test_Colombia.pdf | Artículo de investigación | 76.27 kB | Adobe PDF | Visualizar/Abrir |
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