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https://hdl.handle.net/10495/39573| Título : | Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization |
| Autor : | Castaño Monsalve, Diana María Heit, Bryan Kim, Hani Cosio, Gabriela Collins, Richard Lowell, Clifford A. Kain, Kevin C. Trimble, William S. Gristein, Sergio |
| metadata.dc.subject.*: | Proteínas Adaptadoras Transductoras de Señales Adaptor Proteins, Signal Transducing Western Blotting Blotting, Western Antígenos CD36 CD36 Antigens Metabolismo Metabolism Endocitosis Endocytosis Inmunoprecipitación Immunoprecipitation Péptidos y Proteínas de Señalización Intracelular Intracellular Signaling Peptides and Proteins Macrófagos Peritoneales Macrophages, Peritoneal Fosforilación Phosphorylation Proteínas Tirosina Quinasas Protein-Tyrosine Kinases ARN Interferente Pequeño RNA, Small Interfering Receptores de IgG Receptors, IgG Transducción de Señal Signal Transduction Quinasa Syk Syk Kinase Tetraspanina 28 Tetraspanin 28 Tetraspanina 29 Tetraspanin 29 https://id.nlm.nih.gov/mesh/D048868 https://id.nlm.nih.gov/mesh/D015153 https://id.nlm.nih.gov/mesh/D018955 https://id.nlm.nih.gov/mesh/D008660 https://id.nlm.nih.gov/mesh/D004705 https://id.nlm.nih.gov/mesh/D047468 https://id.nlm.nih.gov/mesh/D047908 https://id.nlm.nih.gov/mesh/D017737 https://id.nlm.nih.gov/mesh/D010766 https://id.nlm.nih.gov/mesh/D011505 https://id.nlm.nih.gov/mesh/D034741 https://id.nlm.nih.gov/mesh/D017452 https://id.nlm.nih.gov/mesh/D015398 https://id.nlm.nih.gov/mesh/D000072377 https://id.nlm.nih.gov/mesh/D060225 https://id.nlm.nih.gov/mesh/D060245 |
| Fecha de publicación : | 2013 |
| Editorial : | Cell Press Elsevier |
| Citación : | Heit B, Kim H, Cosío G, Castaño D, Collins R, Lowell CA, Kain KC, Trimble WS, Grinstein S. Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization. Dev Cell. 2013 Feb 25;24(4):372-83. doi: 10.1016/j.devcel.2013.01.007. |
| Resumen : | ABSTRACT: CD36 is a versatile receptor known to play a central role in the development of atherosclerosis, the pathogenesis of malaria, and the removal of apoptotic cells. Remarkably, the short cytosolically exposed regions of CD36 lack identifiable motifs, which has hampered elucidation of its mode of signaling. Using a combination of phosphoprotein isolation, mass spectrometry, superresolution imaging, and gene silencing, we have determined that the receptor induces ligand internalization through a heteromeric complex consisting of CD36, β1 and/or β2 integrins, and the tetraspanins CD9 and/or CD81. This receptor complex serves to link CD36 to the adaptor FcRγ, which bears an immunoreceptor tyrosine activation motif. By coupling to FcRγ, CD36 is able to engage Src-family kinases and Syk, which in turn drives the internalization of CD36 and its bound ligands. |
| metadata.dc.identifier.eissn: | 1878-1551 |
| ISSN : | 1534-5807 |
| metadata.dc.identifier.doi: | 10.1016/j.devcel.2013.01.007 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| CastañoGloria_2013_Multimolecular_Signaling_Complexes.pdf | Artículo de investigación | 2.65 MB | Adobe PDF | Visualizar/Abrir |
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