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https://hdl.handle.net/10495/41106| Título : | ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| Autor : | Bedoya Berrío, Gabriel de Jesús Ruíz Linares, Andrés Marcelain, Katherine Barahona Ponce, Carol Baez Benavides, Pablo F. Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi González Silos, Rosa Fischer, Christine Scherer, Dominique Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Weiderpass, Elisabete Moradi, Tahereh Fischer, Krista Bossers, Willem Brenner, Hermann Hveem, Kristian Eklund, Niina Völker, Uwe Waldenberger, Melanie Fuentes Guajardo, Macarena González José, Rolando Bortolini, Maria C. Canizales, Samuel Gallo, Carla Boekstegers, Felix Rothhammer, Francisco Bermejo, Justo Lorenzo |
| metadata.dc.subject.*: | ATP Binding Cassette Transporter, Subfamily B Subfamilia B de Transportador de Casetes de Unión a ATP Case-Control Studies Estudios de Casos y Controles Gallbladder Neoplasms Neoplasias de la Vesícula Biliar Genetic Association Studies Estudios de Asociación Genética Genetic Predisposition to Disease Predisposición Genética a la Enfermedad Polymorphism, Single Nucleotide Polimorfismo de Nucleótido Simple Prospective Studies Estudios Prospectivos Retrospective Studies Estudios Retrospectivos Indians, South American Indígenas Sudamericanos Población Blanca White People https://id.nlm.nih.gov/mesh/D018435 https://id.nlm.nih.gov/mesh/D016022 https://id.nlm.nih.gov/mesh/D005706 https://id.nlm.nih.gov/mesh/D056726 https://id.nlm.nih.gov/mesh/D020022 https://id.nlm.nih.gov/mesh/D020641 https://id.nlm.nih.gov/mesh/D011446 https://id.nlm.nih.gov/mesh/D012189 https://id.nlm.nih.gov/mesh/D007199 https://id.nlm.nih.gov/mesh/D044465 |
| Fecha de publicación : | 2020 |
| Editorial : | Elsevier |
| Citación : | Boekstegers F, Marcelain K, Barahona Ponce C, Baez Benavides PF, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, González Silos R, Fischer C, Scherer D, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales S, Gallo C, Ruiz Linares A, Rothhammer F, Lorenzo Bermejo J. ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans. Cancer Epidemiol. 2020 Apr;65:101643. doi: 10.1016/j.canep.2019.101643. |
| Resumen : | ABSTRACT: Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. |
| metadata.dc.identifier.eissn: | 1877-783X |
| ISSN : | 1877-7821 |
| metadata.dc.identifier.doi: | 10.1016/j.canep.2019.101643 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Exactas y Naturales |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| BedoyaGabriel_2020_Gallblader_Cancer_Risk.pdf | Artículo de investigación | 939.11 kB | Adobe PDF | Visualizar/Abrir |
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