1. Repositorio Institucional Universidad de Antioquia
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  3. Instituto de Investigaciones Médicas
  4. Artículos de Revista en Ciencias Médicas
Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/41107
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dc.contributor.authorBalcázar Morales, Norman-
dc.contributor.authorGutiérrez Gómez, Gustavo Adolfo-
dc.contributor.authorGiraldo Dávila, Deisy-
dc.contributor.authorCombariza Montanez, Marianny Yajaira-
dc.contributor.authorHolzgrabe, Ulrike-
dc.contributor.authorTabares Guevara, Jorge Humberto-
dc.contributor.authorRamírez Pineda, José Robinson-
dc.contributor.authorAcín Martínez, Sergio-
dc.contributor.authorMuñoz Herrera, Diana Lorena-
dc.contributor.authorMontoya Pelaéz, Guillermo León-
dc.date.accessioned2024-08-12T03:58:23Z-
dc.date.available2024-08-12T03:58:23Z-
dc.date.issued2020-
dc.identifier.citationGutiérrez G, Giraldo-Dávila D, Combariza MY, Holzgrabe U, Tabares-Guevara JH, Ramírez-Pineda JR, Acín S, Muñoz DL, Montoya G, Balcazar N. Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model. Molecules. 2020 Mar 25;25(7):1486. doi: 10.3390/molecules25071486.spa
dc.identifier.urihttps://hdl.handle.net/10495/41107-
dc.description.abstractABSTRACT: Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.spa
dc.format.extent15 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherMDPIspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleSerjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Modelspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.publisher.groupInmunomodulaciónspa
dc.identifier.doi10.3390/molecules25071486-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1420-3049-
oaire.citationtitleMoleculesspa
oaire.citationstartpage1spa
oaire.citationendpage15spa
oaire.citationvolume25spa
oaire.citationissue7spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameUniversidad de Antioquiaspa
oaire.fundernameUniversidad Icesispa
oaire.fundernameBanco de la República Colombiaspa
oaire.fundernameSistema General de Regalías de Colombiaspa
dc.publisher.placeBasilea, Suizaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsAdipose Tissue-
dc.subject.decsTejido Adiposo-
dc.subject.decsBiomarkers-
dc.subject.decsBiomarcadores-
dc.subject.decsBody Weight-
dc.subject.decsPeso Corporal-
dc.subject.decsCarbohydrate Metabolism-
dc.subject.decsMetabolismo de los Hidratos de Carbono-
dc.subject.decsDiet, High-Fat-
dc.subject.decsDieta Alta en Grasa-
dc.subject.decsDisease Models, Animal-
dc.subject.decsModelos Animales de Enfermedad-
dc.subject.decsGene Expression Regulation-
dc.subject.decsRegulación de la Expresión Génica-
dc.subject.decsInsulin Secretion-
dc.subject.decsSecreción de Insulina-
dc.subject.decsLiver-
dc.subject.decsHígado-
dc.subject.decsObesity-
dc.subject.decsObesidad-
dc.subject.decsOrgan Size-
dc.subject.decsTamaño de los Órganos-
dc.subject.decsTriterpenes-
dc.subject.decsTriterpenos-
dc.description.researchgroupidCOL0006723spa
dc.description.researchgroupidCOL0038389spa
oaire.awardnumber137C-2014spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000273-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015415-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D001835-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D050260-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D059305-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004195-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005786-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D000078790-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D008099-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D009765-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D009929-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D014315-
dc.relation.ispartofjournalabbrevMoleculesspa
oaire.funderidentifier.rorRoR:03bp5hc83-
oaire.funderidentifier.rorRoR:02t54e151-
oaire.funderidentifier.rorRoR:01shra089-
oaire.funderidentifier.rorRoR:05x7bg352-
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