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dc.contributor.authorUsme Ciro, José Aldemar-
dc.contributor.authorCampillo Pedroza, Natalia-
dc.contributor.authorAlmazán, Fernando-
dc.contributor.authorGallego Gómez, Juan Carlos-
dc.date.accessioned2024-08-26T01:57:39Z-
dc.date.available2024-08-26T01:57:39Z-
dc.date.issued2013-
dc.identifier.citationUsme-Ciro JA, Campillo-Pedroza N, Almazán F, Gallego-Gomez JC. Cytoplasmic RNA viruses as potential vehicles for the delivery of therapeutic small RNAs. Virol J. 2013 Jun 7;10:185. doi: 10.1186/1743-422X-10-185.spa
dc.identifier.urihttps://hdl.handle.net/10495/41437-
dc.description.abstractABSTRACT: Viral vectors have become the best option for the delivery of therapeutic genes in conventional and RNA interference-based gene therapies. The current viral vectors for the delivery of small regulatory RNAs are based on DNA viruses and retroviruses/lentiviruses. Cytoplasmic RNA viruses have been excluded as viral vectors for RNAi therapy because of the nuclear localization of the microprocessor complex and the potential degradation of the viral RNA genome during the excision of any virus-encoded pre-microRNAs. However, in the last few years, the presence of several species of small RNAs (e.g., virus-derived small interfering RNAs, virus-derived short RNAs, and unusually small RNAs) in animals and cell cultures that are infected with cytoplasmic RNA viruses has suggested the existence of a non-canonical mechanism of microRNA biogenesis. Several studies have been conducted on the tickborne encephalitis virus and on the Sindbis virus in which microRNA precursors were artificially incorporated and demonstrated the production of mature microRNAs. The ability of these viruses to recruit Drosha to the cytoplasm during infection resulted in the efficient processing of virus-encoded microRNA without the viral genome entering the nucleus. In this review, we discuss the relevance of these findings with an emphasis on the potential use of cytoplasmic RNA viruses as vehicles for the efficient delivery of therapeutic small RNAsspa
dc.format.extent10 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherBMC (BioMed Central)spa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleCytoplasmic RNA viruses as potential vehicles for the delivery of therapeutic small RNAsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupGrupo Medicina Molecular y de Translaciónspa
dc.identifier.doi10.1186/1743-422X-10-185-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1743-422X-
oaire.citationtitleVirology Journalspa
oaire.citationstartpage1spa
oaire.citationendpage10spa
oaire.citationvolume10spa
oaire.citationissue185spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
oaire.fundernameUniversidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODIspa
oaire.fundernameColombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasspa
dc.publisher.placeLondres, Inglaterraspa
dc.type.coarhttp://purl.org/coar/resource_type/c_dcae04bcspa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTREVspa
dc.type.localArtículo de revisiónspa
dc.subject.decsVirus ARN-
dc.subject.decsRNA Viruses-
dc.subject.decsMicroARNs-
dc.subject.decsMicroRNAs-
dc.subject.decsTerapia Genética-
dc.subject.decsGenetic Therapy-
dc.subject.decsCitoplasma-
dc.subject.decsCytoplasm-
dc.subject.decsPortadores de Fármacos-
dc.subject.decsDrug Carriers-
dc.subject.decsVectores Genéticos-
dc.subject.decsGenetic Vectors-
dc.subject.decsInterferencia de ARN-
dc.subject.decsRNA Interference-
dc.subject.decsARN Pequeño no Traducido-
dc.subject.decsRNA, Small Untranslated-
dc.description.researchgroupidCOL0140139spa
oaire.awardnumberCODI 2009-2010spa
oaire.awardnumberMinCiencias 111545921525 y 111554531621spa
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D012328-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D035683-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D015316-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D003593-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D004337-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D005822-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D034622-
dc.subject.meshurihttps://id.nlm.nih.gov/mesh/D058727-
dc.relation.ispartofjournalabbrevVirol. J.spa
oaire.funderidentifier.rorRoR:03bp5hc83-
oaire.funderidentifier.rorRoR:03fd5ne08-
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