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Título : Esclerosis lateral amiotrófica : actualización
Otros títulos : Amyotrophic lateral sclerosis : update
Autor : Zapata Zapata, Carlos Hugo
Franco Dáger, Edwing
Solano Atehortúa, Juan Marcos
Ahunca Velásquez, Luisa Fernanda
metadata.dc.subject.*: Esclerosis Amiotrófica Lateral
Enfermedad de la Neurona Motora
Motor Neuron Disease
Neuronas Motoras
Motor Neurons
Amyotrophic Lateral Sclerosis
Fecha de publicación : 2016
Editorial : Universidad de Antioquia, Facultad de Medicina
Citación : Zapata-Zapata CH, Franco-Dager E, Solano-Atehortúa JM, Ahunca-Velásquez LF. Esclerosis lateral amiotrófica: actualización. Iatreia. 2016 ;29(2):194-205. DOI: 10.17533/udea.iatreia.v29n2a08.
Resumen : Amyotrophic lateral sclerosis is a neurodegenerative disease with devastating consequences for the patient and his/her family. Its etiology is still not clear. In about 10 % of the patients there is a hereditary pattern of the disease. Worldwide, prevalence ranges from 2 to 11 cases per 100,000 people. Age of presentation varies from 58 to 63 years for sporadic cases, and from 47 to 52 years for the familial ones. Concerning gender, there is a slight preference for males. Clinical manifestations include signs of upper and lower motor neurons, damage in limbs and bulbar muscles, and, in some patients, frontotemporal cognitive dysfunction. Diagnosis is essentially clinical supported by neurophysiological studies, such as needle electromyography, which is the most important test for early diagnosis. There is no cure, but riluzol has proven to delay the use of mechanical ventilation and to slightly prolong survival. Consequently, management is based on support measures, such as those related to nutrition and ventilatory function, in addition to control of the motor and non-motor symptoms of the disease.
ISSN : 01210793
20117965 E
metadata.dc.identifier.doi: 10.17533/udea.iatreia.v29n2a08
Aparece en las colecciones: Instituto de Investigaciones Médicas

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