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Título : New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
Autor : Barea, Carlos
Pabón Vidal, Adriana Lucía
Pérez Silanes, Silvia
Galiano, Silvia
González, Germán
Monge, Antonio
Deharo, Eric
Aldana Moraza, Ignacio
Palabras clave : Antiplasmodial
Leishmanicidal
Quinoxaline
Fecha de publicación : 2013
Editorial : Board
Citación : Barea, C., Pabón, A., Pérez-Silanes, S., Galiano, S., Gonzalez, G., Monge, A., ... & Aldana, I. (2013). New amide derivatives of quinoxaline 1, 4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules, 18(4), 4718-4727. DOI:10.3390/molecules18044718
Abstract : Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position
Grupo de INV. : Grupo Malaria
URI : http://hdl.handle.net/10495/7889
ISSN : 14203049
14203049 E
Aparece en las colecciones: Instituto de Investigaciones Médicas

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