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dc.contributor.authorColorado Ríos, Jhonny-
dc.contributor.authorMuñoz Lasso, Diana Carolina-
dc.contributor.authorMontoya Peláez, Guillermo León-
dc.contributor.authorMárquez Fernández, Diana Margarita-
dc.contributor.authorMárquez Fernández, María Elena-
dc.contributor.authorLópez Ortíz, Juan Bautista-
dc.contributor.authorMartínez Martínez, Alejandro-
dc.date.accessioned2017-10-10T19:35:07Z-
dc.date.available2017-10-10T19:35:07Z-
dc.date.issued2013-
dc.identifier.citationJ. Colorado-Ríos, D. C. Muñoz-Lasso, G. L. Montoya-Peláez, D. M. Márquez-Fernández, M. E. Márquez-Fernández, J. B. López-Ortíz and A. Martínez-Martínez, "HPLC-ESI-IT-MS/MS Analysis and biological activity of triterpene glycosides from the colombian marine sponge Ectyoplasia ferox," Mar. Drugs, vol. 11, pp. 4815-4833, 2013.spa
dc.identifier.issn1660-3397-
dc.identifier.urihttp://hdl.handle.net/10495/8526-
dc.description.abstractABSTARCT: The marine sponge Ectyoplasia ferox produces antipredatory and allelopathic triterpenoid glycosides as part of its chemical defense repertoire against predators, competitors, and fouling organisms. These molecules are responsible for the pharmacological potential found in the glycosides present in this species. In order to observe the glycochemical diversity present in E. ferox, a liquid chromatography coupled to a tandem mass spectrometry approach to analyse a complex polar fraction of this marine sponge was performed. This gave valuable information for about twenty-five compounds three of which have been previously reported and another three which were found to be composed of known aglycones. Furthermore, a group of four urabosides, sharing two uncommon substitutions with carboxyl groups at C-4 on the terpenoid core, were identified by a characteristic fragmentation pattern. The oxidized aglycones present in this group of saponins can promote instability, making the purification process difficult. Cytotoxicity, cell cycle modulation, a cell cloning efficiency assay, as well as its hemolytic activity were evaluated. The cytotoxic activity was about IC50 40 μg/mL on Jurkat and CHO-k1 cell lines without exhibiting hemolysis. Discussion on this bioactivity suggests the scanning of other biological models would be worthwhile.spa
dc.format.extent18spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherMDPIspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia*
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/*
dc.subjectEctyoplasia ferox-
dc.subjectEsponja marina-
dc.subjectGlucósidos triterpenoides-
dc.subjectEspectrometría de masas-
dc.subjectMass spectrometry-
dc.titleHPLC-ESI-IT-MS/MS Analysis and biological activity of triterpene glycosides from the colombian marine sponge Ectyoplasia feroxspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupProductos Naturales Marinosspa
dc.identifier.doi10.3390/md11124815-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a86spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.citationtitleMarine Drugsspa
oaire.citationstartpage4815spa
oaire.citationendpage4833spa
oaire.citationvolume11spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.publisher.placeSuizaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.relation.ispartofjournalabbrevMar. Drugsspa
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