Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10495/9128
Título : Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility
Autor : Puerta Suárez, Jenniffer
Sánchez, Leonardo R.
Salazar, Florencia C.
Saka, Hector A.
Molina Molina, Rosa
Tissera, Andrea
Cardona Maya, Walter Darío
Motrich, Ruben D.
metadata.dc.subject.*: Spermatozoa
Fertility, Human
Fecundidad humana
Bacterial diseases
Enfermedades bacterianas
Fecha de publicación : 2017
Editorial : Nature Publishing Group
Citación : Puerta Suárez J, Sánchez LR, Salazar FC, Saka HA, Molina R, Tissera A, Rivero VE, Cardona Maya WD, Motrich RD. Chlamydia trachomatis neither exerts deleterious effects on spermatozoa nor impairs male fertility. Sci Rep. 2017;7(1126): 1-14. DOI:10.1038/s41598-017-01262-w
Resumen : ABSTARCT: Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether Chlamydia trachomatis has a negative impact on sperm quality and male fertility is still controversial. Herein, we report the effects on sperm quality of the in vitro exposure of spermatozoa to Chlamydia trachomatis, and also the effects of male genital infection on male fertility using an animal model. Human and mouse sperm were obtained from healthy donors and cauda epididimys from C57BL/6 mice, respectively. Highly motile human or mouse spermatozoa were in vitro exposed to C. trachomatis (serovar E or LGV) or C. muridarum, respectively. Then, sperm quality parameters were analyzed. Moreover, male fertility of Chlamydia muridarum infected male C57BL/6 mice was assessed. Human or murine sperm in vitro exposed to increasing bacterial concentrations or soluble factors from C. trachomatis or C. muridarum, respectively, did not show differences in sperm motility and viability, apoptosis, mitochondrial membrane potential, DNA fragmentation, ROS production and lipid peroxidation levels, when compared with control sperm (p > 0.05). Moreover, no differences in fertility parameters (potency, fecundity, fertility index, pre- and post-implantation loss) were observed between control and infected males. In conclusion, our results indicate that Chlamydia spp. neither directly exerts deleterious effects on spermatozoa nor impairs male fertility.
ISSN : 2045-2322
metadata.dc.identifier.doi: 10.1038/s41598-017-01262-w
Aparece en las colecciones: Instituto de Investigaciones Médicas

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
PuertaSuarezJenniffer_2017_ChlamydiaTrachomatisNeither.pdfArtículo de Revista3.12 MBAdobe PDFVisualizar/Abrir

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons


Gestión de T.I. /Sistema de Bibliotecas / Universidad de Antioquia / Cl. 67 Nº 53 - 108 - Bloque 8 Conmutador: 219 51 51- 219 51 40 bibliotecadigital@udea.edu.co Medellín - Colombia