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https://hdl.handle.net/10495/44431| Título : | Etiologic Diagnosis of Chronic Osteomyelitis: a prospective study |
| Autor : | Zuluaga Salazar, Andrés Felipe Vesga Meneses, Omar Salazar Giraldo, Beatriz Agudelo Pérez, María Saldarriaga, Juan G. Galvis Franco, Wilson de Jesús |
| metadata.dc.subject.*: | Antibacterianos Anti-Bacterial Agents Biopsy Biopsia Bone and Bones Huesos Chronic Disease Enfermedad Crónica Microbial Sensitivity Tests Pruebas de Sensibilidad Microbiana Osteomyelitis Osteomielitis https://id.nlm.nih.gov/mesh/D010019 Estudios Prospectivos Prospective Studies Reproducibility of Results Reproducibilidad de los Resultados Sensibilidad y Especificidad Sensitivity and Specificity Resultado del Tratamiento Treatment Outcome https://id.nlm.nih.gov/mesh/D008826 https://id.nlm.nih.gov/mesh/D000900 https://id.nlm.nih.gov/mesh/D001706 https://id.nlm.nih.gov/mesh/D001842 https://id.nlm.nih.gov/mesh/D002908 https://id.nlm.nih.gov/mesh/D011446 https://id.nlm.nih.gov/mesh/D015203 https://id.nlm.nih.gov/mesh/D012680 https://id.nlm.nih.gov/mesh/D016896 |
| Fecha de publicación : | 2006 |
| Editorial : | American Medical Association |
| Citación : | Zuluaga AF, Galvis W, Saldarriaga JG, Agudelo M, Salazar BE, Vesga O. Etiologic diagnosis of chronic osteomyelitis: a prospective study. Arch Intern Med. 2006 Jan 9;166(1):95-100. doi: 10.1001/archinte.166.1.95. |
| Resumen : | ABSTRACT: Background: Although bone specimens were established 25 years ago as the gold standard for etiologic diagnosis of chronic osteomyelitis, recent studies suggest that nonbone specimens are as accurate as bone to identify the causative agent. We examined concordance rates between cultures from nonbone and bone specimens in 100 patients. Methods: Prospective study conducted at Hospital Universitario San Vicente de Paul, a 750-bed university-based hospital located in Medellín, Colombia. We included patients with chronic osteomyelitis who had been free of antibiotic therapy for at least 48 hours, excluding those with diabetic foot and decubitus ulcers. At least 1 nonbone and 1 bone specimen were taken from each individual and subjected to complete microbiologic analysis. Results: Bone cultures allowed agent identification in 94% of cases, including anaerobic bacteria in 14%. Cultures of nonbone and bone specimens gave identical results in 30% of patients, with slightly better concordance in chronic osteomyelitis caused by Staphylococcus aureus (42%) than by all other bacterial species (22%). However, statistical concordance determined by the Cohen kappa statistic was less than 0 (-0.0092+/-0.0324), indicating that the observed concordance was no better than that expected by chance alone (P>.99). Conclusions: Appropriate diagnosis and therapy of chronic osteomyelitis require microbiologic cultures of the infected bone. Nonbone specimens are not valid for this purpose. |
| metadata.dc.identifier.eissn: | 1538-3679 |
| ISSN : | 0003-9926 |
| metadata.dc.identifier.doi: | 10.1001/archinte.166.1.95 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Médicas |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| ZuluagaAndres_2006_Etiologic_Diagnosis_Chronic_Osteomyelitis.pdf | Artículo de investigación | 109.69 kB | Adobe PDF | Visualizar/Abrir |
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