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dc.contributor.authorVelásquez Rodríguez, Claudia María-
dc.contributor.authorVásquez Márquez, Juan Sebastián-
dc.contributor.authorBalcázar Morales, Norman-
dc.date.accessioned2019-08-16T13:16:06Z-
dc.date.available2019-08-16T13:16:06Z-
dc.date.issued2017-
dc.identifier.citationVelásquez C, Vásquez J, Balcazar N. In vitro effect of fatty acids identified in the plasma of obese adolescents on the function of pancreatic β-Cells. Diabetes Metab J. 2017; 41(4): 303-15. DOI: 10.4093/dmj.2017.41.4.303spa
dc.identifier.issn2233-6079-
dc.identifier.urihttp://hdl.handle.net/10495/11657-
dc.description.abstractABSTRACT: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic β-cells. We evaluated the effect of FFAs reconstituted according to the profile of circulating fatty acids found in obese adolescents on the viability and function of the murine insulinoma cell line (mouse insulinoma [MIN6]). Methods: From fatty acids obtained commercially, plasma-FFA profiles of three different youth populations were reconstituted: obese with metabolic syndrome; obese without metabolic syndrome; and normal weight without metabolic syndrome. MIN6 cells were treated for 24 or 48 hours with the three FFA profiles, and glucose-stimulated insulin secretion, cell viability, mitochon-drial function and antioxidant activity were evaluated. Results: The high FFA content and high polyunsaturated ω6/ω3 ratio, present in plasma of obese adolescents with metabolic syn- drome had a toxic effect on MIN6 cell viability and function, increasing oxidative stress and decreasing glucose-dependent insulin secretion. Conclusion: These results could help to guide nutritional management of obese young individuals, encouraging the increase of ω-3-rich food consumption in order to reduce the likelihood of deterioration of β-cells and the possible development of type 2 diabetes mellitus.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherDiabetes & Metabolism Journalspa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsAtribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)*
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/2.5/co/*
dc.subjectFatty acids-
dc.subjectNonesterified-
dc.subjectInsulin-secreting cells-
dc.subjectLipotoxicity-
dc.subjectMetabolic syndrome-
dc.subjectObesity-
dc.titleIn vitro effect of fatty acids identified in the plasma of obese adolescents on the function of pancreatic β-Cellsspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupAlimentación y Nutrición Humanaspa
dc.publisher.groupGenética Molecular (GENMOL)spa
dc.identifier.doi10.4093/dmj.2017.41.4.303-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn2233-6087-
oaire.citationtitleDiabetes & Metabolism Journalspa
oaire.citationstartpage303spa
oaire.citationendpage315spa
oaire.citationvolume41spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.publisher.placeSeúl, Coreaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.description.researchgroupidCOL0000407spa
dc.description.researchgroupidCOL0006723spa
dc.relation.ispartofjournalabbrevDiabetes Metab Jspa
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