Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/20075
Título : A point mutation V419L in the sodium channel gene from natural populations of Aedes aegypti is involved in resistance to λ-Cyhalothrin in Colombia
Autor : Granada Garzón, Yurany Eresbey
Mejía Jaramillo, Ana María
Strode, Clare
Triana Chávez, Omar
metadata.dc.subject.*: Resistencia a insecticidas
Resistance to insecticides
Gen del canal de sodio
Resistencia a piretroides
Fecha de publicación : 2018
Editorial : MDPI
Resumen : ABSTRACT: Colombian municipalities. A partial region coding for the sodium channel gene from resistant mosquitoes was sequenced, and a simple allele-specific PCR-based assay (AS-PCR) was used to analyze mutations at the population level. The previously reported mutations, V1016I and F1534C, were found with frequencies ranging from 0.04 to 0.41, and 0.56 to 0.71, respectively, in the three cities. Moreover, a novel mutation, at 419 codon (V419L), was found in Ae. aegypti populations from Bello, Riohacha and Villavicencio cities with allelic frequencies of 0.06, 0.36, and 0.46, respectively. Interestingly, the insecticide susceptibility assays showed that mosquitoes from Bello were susceptible to λ-cyhalothrin pyrethroid whilst those from Riohacha and Villavicencio were resistant. A positive association between V419L and V1016I mutations with λ-cyhalothrin resistance was established in Riohacha and Villavicencio. The frequency of the F1534C was high in the three populations, suggesting that this mutation could be conferring resistance to insecticides other than λ-cyhalothrin, particularly type I pyrethroids. Further studies are required to confirm this hypothesis.
metadata.dc.identifier.eissn: 2075-4450
metadata.dc.identifier.doi: 10.3390/insects9010023
metadata.dc.identifier.url: https://www.mdpi.com/2075-4450/9/1/23/htm
Aparece en las colecciones: Artículos de Revista en Ciencias Exactas y Naturales

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
GranadaYurany_2018_MutationAedesAegypti.pdfArtículo de investigación2.15 MBAdobe PDFVisualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons