Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/10495/21295
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorLópez Jaramillo, Patricio-
dc.contributor.authorRincón Acelas, Melvin Yesid-
dc.contributor.authorGarcía Gómez, Ronal Guillermo-
dc.contributor.authorSilva, Sandra Y-
dc.contributor.authorSmith, Erin-
dc.contributor.authorKampeerapappun, Piyaporn-
dc.contributor.authorGarcía, Carlos-
dc.contributor.authorVélez Bernal, Iván Darío-
dc.contributor.authorLópez, Marcos-
dc.date.accessioned2021-07-29T20:13:52Z-
dc.date.available2021-07-29T20:13:52Z-
dc.date.issued2010-
dc.identifier.citationLópez-Jaramillo, P., Rincón, M. Y., García, R. G., Silva, S. Y., Smith, E., Kampeerapappun, P., García, C., Smith, D. J., López, M., & Vélez, I. D. (2010). A Controlled, Randomized-Blinded Clinical Trial to Assess the Efficacy of a Nitric Oxide Releasing Patch in the Treatment of Cutaneous Leishmaniasis by Leishmania (V.) panamensis, The American Society of Tropical Medicine and Hygiene, 83(1), 97-101. Retrieved Jul 29, 2021, from https://www.ajtmh.org/view/journals/tpmd/83/1/article-p97.xmlspa
dc.identifier.issn0002-9637-
dc.identifier.urihttp://hdl.handle.net/10495/21295-
dc.description.abstractABSTRACT: A topical nanofiber nitric oxide (NO) releasing patch (≈3.5 μmol NO/cm2/day for 20 days, NOP) was compared with intramuscular meglumine antimoniate (Glucantime, 20 mg/kg/day for 20 days) for the treatment of cutaneous leishmaniasis (CL) caused by Leishmania (V.) panamensis in Santander and Tolima, Colombia. A double-blind, randomized, placebo-controlled, clinical trial was conducted to determine whether the NOP is as effective as Glucantime for the treatment of CL. Patients were randomly assigned to Glucantime and placebo patches or NOP and placebo of Glucantime. The cure rates after a 3-month follow-up were 94.8% for the group that received Glucantime compared with 37.1% in the NOP group. Despite the lower efficacy of the NOP versus Glucantime, a significantly lower frequency of non-serious adverse events and a reduced variation in serum markers were observed in patients treated with NOP. Treatment of CL with NOP resulted in a lower effectiveness compared with Glucantime; however, the low frequency of adverse events and the facility of topic administration justify the development of new generations of NOP systems for the treatment of CLspa
dc.format.extent5spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.publisherAmerican Society of Tropical Medicine and Hygienespa
dc.type.hasversioninfo:eu-repo/semantics/publishedVersionspa
dc.rightsinfo:eu-repo/semantics/openAccessspa
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/co/*
dc.titleA Controlled, Randomized-Blinded Clinical Trial to Assess the Efficacy of a Nitric Oxide Releasing Patch in the Treatment of Cutaneous Leishmaniasis by Leishmania (V.) panamensisspa
dc.typeinfo:eu-repo/semantics/articlespa
dc.publisher.groupPrograma de Estudio y Control de Enfermedades Tropicales (PECET)spa
dc.identifier.doi10.4269/ajtmh.2010.09-0287-
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.rights.accessrightshttp://purl.org/coar/access_right/c_abf2spa
dc.identifier.eissn1476-1645-
oaire.citationtitleAmerican Journal of Tropical Medicine and Hygienespa
oaire.citationstartpage97spa
oaire.citationendpage101spa
oaire.citationvolume83spa
oaire.citationissue1spa
dc.rights.creativecommonshttps://creativecommons.org/licenses/by/4.0/spa
dc.publisher.placeBaltimore, Estados Unidosspa
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1spa
dc.type.redcolhttps://purl.org/redcol/resource_type/ARTspa
dc.type.localArtículo de investigaciónspa
dc.subject.decsÓxido Nítrico-
dc.subject.decsNitric Oxide-
dc.subject.decsEnsayo Clínico Controlado-
dc.subject.decsControlled Clinical Trial-
dc.subject.decsLeishmaniasis Cutánea-
dc.subject.decsLeishmaniasis, Cutaneous-
dc.subject.decsLeishmania-
dc.subject.decsAntimoniato de Meglumina-
dc.subject.decsMeglumine Antimoniate-
dc.description.researchgroupidCOL0015099spa
dc.relation.ispartofjournalabbrevAm. J. Trop. Med. Hyg.spa
Aparece en las colecciones: Artículos de Revista en Ciencias Médicas

Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
VelezIvan_ 2010_TreatmentutaneousLeishmaniasis.pdfArtículo de investigación660.97 kBAdobe PDFVisualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons