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https://hdl.handle.net/10495/23676| Título : | Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| Autor : | Castaño Gil, Yenni Marcela Cardona Galeano, Wilson Quiñones Fletcher, Winston Robledo Restrepo, Sara María Echeverrí López, Luis Fernando |
| metadata.dc.subject.*: | Metathesis Lactones Lactonas Leishmania http://aims.fao.org/aos/agrovoc/c_4145 http://aims.fao.org/aos/agrovoc/c_24350 http://id.loc.gov/authorities/subjects/sh85084301 |
| Fecha de publicación : | 2009 |
| Editorial : | MDPI |
| Citación : | Castaño, M., Cardona, W., Quiñones, W., Robledo, S., & Echeverri, F. (2009). Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules, 14(7), 2491–2500. Retrieved from http://dx.doi.org/10.3390/molecules14072491 |
| Resumen : | ABSTRACT: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index. |
| metadata.dc.identifier.eissn: | 1420-3049 |
| metadata.dc.identifier.doi: | 10.3390/molecules14072491 |
| Aparece en las colecciones: | Artículos de Revista en Ciencias Exactas y Naturales |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| CastañoMarcela_2009_LeishmanicidalAliphaticAromatic.pdf | Artículo de investigación | 221.05 kB | Adobe PDF | Visualizar/Abrir |
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